School of Medicine
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Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Narayan directs the Computational Arrhythmia Research Laboratory, whose goal is to define the mechanisms underlying complex human heart rhythm disorders, to develop bioengineering-focused solutions to improve therapy that will be tested in clinical trials. The laboratory has been funded continuously since 2001 by the National Institutes of Health, AHA and ACC, and interlinks a disease-focused group of clinicians, computational physicists, bioengineers and trialists.
Duy T Nguyen
Clinical Associate Professor, Medicine - Cardiovascular Medicine
Current Research and Scholarly Interests The long-term goals of my translational research are to evaluate novel radiofrequency (RF) ablation strategies, catheter designs to improve procedural efficacy and safety outcomes, and molecular targets to enhance RF ablation of atrial fibrillation and ventricular tachycardia. We have translational and clinical studies on multiple ablation catheter designs as well as ablation strategies to improve safety and maximize RF delivery during ablation for atrial fibrillation and ventricular tachycardia. We have both in vivo and ex vivo animal models (small and large animal) of atrial and ventricular arrhythmias.
At the translational level, our ablation biophysics studies include utilizing various nanomaterials to help facilitate ablation as well as designing specialized catheters to improve safety and efficacy of ablation. We are studying specific variations in catheter design to improve ablation; testing delivery methods of facilitating agents; optimizing biophysical parameters; determining the precise RF electromagnetic field to minimize collateral damage; and studying magnetic driven facilitating agents.
At the clinical level, my research has focused on the application of biophysical principles to AF and VT ablation outcomes, in addition to research related to adult congenital heart disease. Projects include a multicenter consortium on the use of EP studies in risk stratification of sudden death for Tetralogy of Fallot (ToF) patients undergoing pulmonary valve replacement; perioperative EP studies and VT ablation in ToF patients; outcomes in multicenter cohorts of ACHD patients undergoing AF and VT ablations; and outcomes in ACHD subpopulations undergoing EP procedures, such as those with bicuspid aortic valves, right atrial myopathies, and others.
Associate Professor of Medicine (Cardiovascular Medicine) and of Radiology (CV Imaging) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr Nieman investigates advanced cardiac imaging techniques. Current projects focus on the development of functional CT application for hemodynamic interpretation of coronary artery disease, and the clinical validation of cardiac CT in the management of patients with ischemic heart disease.