School of Medicine
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Clinical Instructor, Medicine - Cardiovascular Medicine
Bio Prior to a career in medicine, Dr. Chang was an English major and subsequent novelist at night. During the days, he taught literature part-time at Rutgers University, and for extra money, worked in a laboratory in NYC washing test tubes. Inspired by his laboratory mentor, he began volunteering at the hospital next door, and developed a love for interacting with patients. Through this experience, he saw how caring for others could form deep bonds between people - even strangers - and connect us in a way that brings grandeur to ordinary life.
In addition to seeing patients, Dr. Chang is a physician-scientist devoted to advancing the field of cardiovascular medicine. His research has been focused on identifying a new genetic organism that better models human heart disease than the mouse. For this purpose, he has been studying the mouse lemur, the smallest non-human primate, performing cardiovascular phenotyping (vital signs, ECG, echocardiogram) on lemurs both in-bred (in France) and in the wild (in Madagascar) to try to identify mutant cardiac traits that may be heritable - and in the process, characterize the first high-throughput primate model of human cardiac disease.
Professor of Medicine (Oncology) and of Biochemistry
Current Research and Scholarly Interests Our laboratory seeks to understand how cells repair DNA damage. We currently focus on how non-homologous end joining proteins assemble on DNA ends to juxtapose them for repair of DNA double-strand breaks.
We are collaborating on a point-of-care device to measure ammonia from a drop of blood. The device will facilitate diagnosis and management of urea cycle defects, liver disease, and chemobrain due to elevated ammonia.