School of Medicine

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  • Mohsen Fathzadeh

    Mohsen Fathzadeh

    Postdoctoral Research Fellow, Cardiovascular Medicine

    Bio My long-term goal is to investigate the functional genomics of rare and common variants that cause metabolic and cardiovascular comorbidity. In particular, I am interested in the genetics of insulin resistance as major underlying risk factor for cardiometabolic diseases.
    After completing my master?s degree, I was attracted by the hypothesis that early onset coronary artery disease (CAD) is a genetic subtype of the common type of CAD. In collaboration with Dr. Arya Mani, an expert in Mendelian forms of CAD (Yale University), and Prof Reza Malekzadeh, a pioneer of cohort studies (Tehran University), and HHMI investigator in Yale University, Dr. Richard Lifton, I contributed to the genetic analysis of families with early onset CAD and metabolic syndrome. We identified DYRK1B as a causative gene (co-first author; N Engl J Med; 2014).
    During my PhD thesis, I worked on exome data of Mendelian/monogenic disorders that have been sequenced at Yale Genome center to filter them for rare and pathogenic variants. Also, I used RNA-Seq to sequence the transcriptome of human skeletal muscle biopsies from the carriers and non-carriers of the DYRK1B mutation. I also applied LFQ-MS (label free quantification- tandem mass spectrometry) to address changes in the proteome of DYRK1B mutants in both human muscle biopsies and in vitro models. Through these studies I gained an experimental and conceptual framework for high-throughput data analyses focusing on the networks of metabolic pathways for insulin resistance.
    I am enthusiastic to pursue functional genomic characterization of genes found through GWAS of Insulin Resistance with fantastic group of investigators at Stanford medicine.

  • Natalie Fischer

    Natalie Fischer

    Postdoctoral Research Fellow, Infectious Diseases

    Current Research and Scholarly Interests Studying the host-microbiome relationship in very early-onset inflammatory bowel disease via microbial DNA sequencing and analysis. Evaluating expression of antimicrobial peptides and other immune mediators in human stool via mass spectrometry in collaboration with the Elisa lab on campus.

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