Professional Education
-
Bachelor of Science, University of Dayton (2011)
-
Doctor of Philosophy, University of Colorado Boulder (2017)
Bio
Publications
All Publications
-
The Genetics of Aging: A Vertebrate Perspective
CELL
2019; 177 (1): 200?220
View details for DOI 10.1016/j.cell.2019.02.038
View details for Web of Science ID 000462034400022
-
The Genetics of Aging: A Vertebrate Perspective.
Cell
2019; 177 (1): 200?220
Abstract
Aging negatively impacts vitality and health. Many genetic pathways that regulate aging were discovered in invertebrates. However, the genetics of aging is more complex in vertebrates because of their specialized systems. This Review discusses advances in the genetic regulation of aging in vertebrates from work in mice, humans, and organisms with exceptional lifespans. We highlight challenges for the future, including sex-dependent differences in lifespan and the interplay between genes and environment. We also discuss how the identification of reliable biomarkers of age and development of new vertebrate models can be leveraged for personalized interventions to counter aging and age-related diseases.
View details for PubMedID 30901541