Current Research and Scholarly Interests
We wish to develop new therapies to prevent and treat the respiratory distress syndrome (RDS) and its sequelae, bronchopulmonary dysplasia (BPD). In the pursuit of this goal my laboratory has conducted research on how the lungs airspaces become fluid filled (mechanisms of pulmonary edema) and how airspace fluid is cleared under both physiologic (fetal lung liquid at birth) and pathophysiologic (pulmonary edema) conditions. Since the rate limiting step in airspace fluid clearance is the active transport of Na+ by distal lung epithelium, our studies had investigated the effect of lung maturity, mediators and hormones on the pre and post-translational regulation of the epithelial Na+ channel (ENaC). My current research involves a population based study to discover the genetic influences on the development of BPD.