Bio

Honors & Awards


  • NIH National Eye Institute F32 Postdoctoral Fellowship, National Institute of Health (June 2019 - June 2021)
  • NIH T32 Postdoctoral Fellow Training Grant Recipient, Stanford Department of Ophthalmology (May 2018-April 2019)

Boards, Advisory Committees, Professional Organizations


  • Member-in-Training, Association for Research in Vision and Ophthalmology (2015 - Present)

Professional Education


  • Doctor of Philosophy, Univesity of North Texas Health Science Center (2017)
  • Bachelor of Science, University of Texas Arlington (2012)

Publications

All Publications


  • Loss of optineurin C-terminus causes significant retinal ganglion cell degeneration Webber, H., Huang, H., Li, L., Zhang, J., Zhuang, P., Wang, Q., Hu, Y. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2019
  • Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse. eLife Zhang, J., Li, L., Huang, H., Fang, F., Webber, H. C., Zhuang, P., Liu, L., Dalal, R., Tang, P. H., Mahajan, V. B., Sun, Y., Li, S., Zhang, M., Goldberg, J. L., Hu, Y. 2019; 8

    Abstract

    Understanding the molecular mechanism of glaucoma and development of neuroprotectants are significantly hindered by the lack of a reliable animal model that accurately recapitulates human glaucoma. Here we sought to develop a mouse model for the secondary glaucoma that is often observed in humans after silicone oil (SO) blocks the pupil or migrates into the anterior chamber following vitreoretinal surgery. We observed significant intraocular pressure (IOP) elevation after intracameral injection of SO, and that SO removal allows IOP to return quickly to normal. This simple, inducible and reversible mouse ocular hypertension model shows dynamic changes of visual function that correlate with progressive RGC loss and axon degeneration. It may be applicable with only minor modifications to a range of animal species in which it will generate stable, robust IOP elevation and significant neurodegeneration that will facilitate selection of neuroprotectants and investigating the pathogenesis of ocular hypertension-induced glaucoma.

    View details for PubMedID 31090540