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Neurobiology of sleep, circadian rhythms, regulation of body temperature, mammalian hibernation, and human exercise physiology. We study neural mechanisms controlling arousal states and arousal state transitions, the function of sleep, and the neural mechanisms of circadian rhythms. Research on human exercise physiology focuses on the effects of body temperature on physical conditioning and performance. The focus on Down syndrome is exploring the mechanism whereby reduction of GABA activity restores learning and memory in DS mice and also in mouse models of Alzheimer's disease.