Bio

Clinical Focus


  • Internal Medicine
  • Peri-operative medical management

Academic Appointments


Administrative Appointments


  • Director, PA student rotations, Surgical Co-management Hospitalist (2012 - Present)

Professional Education


  • Internship:UCSF-Internal Medicine (1995) CA
  • Residency:UCSF-Internal Medicine (1997) CA
  • Board Certification: Internal Medicine, American Board of Internal Medicine (1997)
  • Medical Education:Indira Gandhi Medical College (1992) India

Publications

Journal Articles


  • IN-VIVO AND IN-VITRO EFFECTS OF MACROPHAGE-COLONY-STIMULATING FACTOR (M-CSF) ON BRONCHOALVEOLAR MACROPHAGES FOR ANTIHISTOPLASMAL ACTIVITY INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY Khemani, S., Brummer, E., Stevens, D. A. 1995; 17 (1): 49-53

    Abstract

    The in vivo and in vitro effects of M-CSF on bronchoalveolar macrophages (BAM) activity against the intracellular fungal pathogen Histoplasma capsulatum (Hc) were studied. Three days after a single subcutaneous (s.c.) dose of M-CSF (2.5 mg/kg), enhanced ex vivo antifungal activity of BAM was measured. BAM from M-CSF-treated CD-1 mice significantly (P < 0.01) inhibited the intracellular multiplication of Hc yeast cells in 20 h assays compared to BAM from control mice. This effect was not observed at days 1, 7, 11 or 21 post-treatment. A dose of 5 mg/kg s.c., but not 1 mg/kg, induced similar antifungal activity in BAM by day 3. Peritoneal macrophages (PM) from M-CSF-treated mice did not have enhanced antifungal activity at days and doses tested. BAM could also be activated for antihistoplasmal activity by M-CSF in vitro. M-CSF at 10,000 U/ml for 24 h or 5000 U/ml for 48 h induced significant (P < 0.01) inhibition of intracellular multiplication of Hc. Interferon-gamma (IFN) plus lipopolysaccharide (LPS) activated BAM and PM in vitro to inhibit intracellular multiplication of Hc (P < 0.001); the antihistoplasmal activity was completely inhibited by NG-monomethyl L-arginine (N-MMA), indicating that an L-arginine-dependent nitric oxide-producing mechanism was operative. N-MMA could not inhibit the antihistoplasmal activity of BAM or PM activated by M-CSF in vitro. The mechanism by which M-CSF-activated macrophages inhibit intracellular multiplication of Hc remains to be determined.

    View details for Web of Science ID A1995QN91500006

    View details for PubMedID 7782153

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