Current Research and Scholarly Interests
My research is focused on the development and clinical translation of novel quantitative and molecularly specific imaging technologies geared toward detection of disease at the earliest causative stages. Specifically, I am motivated to study the causes and treatment of osteoarthritis (OA) and other musculoskeletal disorders, which have a large physical and financial impact but remain poorly understood. I am developing fast, volumetric chemical exchange saturation transfer (CEST) methods for whole joint imaging of enzymatic degradation of proteoglycans in articular cartilage, an early marker of OA. I am also focused on developing methods for simultaneous musculoskeletal PET and MR imaging to correlate metabolic information about bone remodelling and inflammation from PET with high resolution quantitative MR imaging to detect the earliest changes in OA, in order to provide new insights into OA pathogenesis and ultimately therapies to arrest the onset and progression of OA. Other projects include rapid whole-joint imaging and simultaneous bilateral knee MRI.