Bio
Stem cells are attractive cell sources for regenerative medicine due to their unique capacity of self-renewal and differentiation into multiple lineages. Specifically, our research focuses on the following areas:
I. Fundamental: Understand how microenvironmental cues regulate stem cell fate. We are interested in understanding the effects of interactive signaling on stem cell in 3D and results from such studies would help predict stem cell phenotype in vivo and direct rational design of stem cell niche for tissue engineering applications.
II. Technological: Develop controlled delivery system to direct stem cell differentiation in situ. Our goal is to develop a controlled release system for sustained delivery of synergistic genetic signals to direct stem cells differentiation in situ.
III. Translational: Stem cells for targeting and delivery of therapeutic factors. Many disease processes are associated with abnormal blood supply, cell death and eventual loss of tissue structure and function. We are interested in engineering stem cells for targeting and delivery of therapeutic factors to restore normal vascularization and promote tissue regeneration. Findings from such study would have great translational potential that may benefit patients in the future.
Academic Appointments
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Associate Professor, Orthopaedic Surgery
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Associate Professor, Bioengineering
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Member, Bio-X
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Member, Cardiovascular Institute
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Member, Child Health Research Institute
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Faculty Fellow, Stanford ChEM-H
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Member, Stanford Neurosciences Institute
Honors & Awards
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Ellen Weaver Award for outstanding mentoring and support of other women in science, the Northern California Chapters of the Association for Women in Science (2017)
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Biomaterials Science Lectureship Award, Biomaterials Science (2016)
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Young Investigator Award from the Society for Biomaterials (one winner per year), Society for Bioamterials (2016)
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NSF Faculty Early Career Development (CAREER) award, National Science Foundation (2014-2019)
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Rising Star Award, Biomedical Engineering Society-Cellular and Molecular Engineering, Biomedical Engineering Society (2014)
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Mission for Learning Faculty Scholar Award in Pediatric Translational Medicine, Child Health Research Institute (2013-2015)
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Stanford Asian American Faculty Award, Stanford University (2013)
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Young Investigator Award, Alliance for Cancer and Gene Therapy, Alliance for Cancer and Gene Therapy (2013)
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3M Nontenured Faculty Grant Award, 3M (2012-2015)
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Basil O'Connor Starter Scholar Research Award, March of Dimes Foundation (2012)
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2011 TR35 Global Honoree, Recognized as one of the world's top innovators under age 35, Technology Review (2011)
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Donald E. and Delia B. BaxterFoundation Scholars Award, Baxter Foundation (2010)
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McCormick Faculty Award, Stanford University (2010)
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National Scientist Development Grant Award, American Heart Association (2009-2013)
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Ruth L. Kirschstein National Research Service Award Postdoctoral Fellowship, MIT (2008-2009)
Professional Education
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Ph.D., Johns Hopkins University, Biomedical Engineering (2006)
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B.S., Shanghai Jiaotong University, Biomedical Engineering (2001)
Patents
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Keeney M, Yang F, Goodman S. "United States Patent US9682035B2 Injectable hydrogel system to modulate host response at the bone implant interface", Leland Stanford Junior University, Jun 20, 2017