Current Research and Scholarly Interests
My laboratory focuses on three main areas: 1) studying the genetics underlying the response of tumors to radiation therapy, 2) developing personalized treatment approaches for sarcomas and gastrointestinal malignancies, and 3) understanding tumor clonal evolution during cancer therapy. We perform translational cancer research by analyzing human tissue and blood samples with next-generation sequencing to understand the genetic underpinnings and expression signatures that determine treatment response and resistance. We use genetically engineered mouse models to validate our findings, perform mechanistic experiments, and test new therapies. Clinically, I specialize in the treatment of sarcomas, and I am interested in prospective and retrospective clinical research.
