Bio

Clinical Focus


  • Cardiovascular Surgery

Academic Appointments


Professional Education


  • Fellowship: University of Toronto Hospital for Sick Children Cardiovascular Surg Fellowship (2018) Canada
  • Board Certification: Royal College of Physicians and Surgeons of Canada, Cardiovascular Surgery (2017)
  • Residency: Laval University Cardiac Surgery Residency (2017)
  • MPH, Harvard University (2015)
  • Medical Education: McGill University Faculty of Medicine (2011) Canada

Publications

All Publications


  • Surgical repair of peripheral pulmonary artery stenosis in patients without williams or alagille syndromes. Seminars in thoracic and cardiovascular surgery Martin, E., Mainwaring, R. D., Collins, R. T., MacMillen, K. L., Hanley, F. L. 2020

    Abstract

    Peripheral pulmonary artery stenosis (PPAS) is a relatively rare form of congenital heart disease typically associated with genetic syndromes, such as Williams or Alagille syndromes. However, some patients present with severe stenosis without associated syndromes. The purpose of the study was to review our surgical experience in such patients. This was a retrospective review of 30 patients who underwent surgical repair for peripheral pulmonary artery stenosis. Concomitant anatomical diagnoses in 20 patients (67%) included: supravalvar aortic stenosis (n=8), tetralogy of Fallot (n=4), d-transposition of the great arteries (n=2), truncus arteriosus (n=2), hypoplastic left heart syndrome (n=2), ventricular septal defect (n=1), and patent ductus arteriosus (n=1). Additional medical diagnoses in 15 patients (50%) included: elastin arteriopathy (n=9), pulmonary artery calcinosis (n=1), arterial tortuosity syndrome (n=1), DiGeorge syndrome (n=1) and Noonan syndrome (n=1). Median age at surgery was 3.6 years (IQR 1.6-7.4 years). Seventeen patients (57%) had prior cardiac operations, and 16 patients (53%) previously underwent percutaneous intervention. With surgery, mean right ventricle-to-aortic systolic pressure ratio decreased from 0.95±0.2 to 0.28±0.08 (p<0.0001). Median duration of cardiopulmonary bypass was 369 minutes. There was 100% survival to hospital discharge, with no mortality at mean follow-up of 2.3 years. No patient required reoperation, while 4 underwent balloon dilation. Freedom from pulmonary artery catheter-based reintervention was 95% and 80% at 12 and 36 months, respectively. Patients with peripheral pulmonary artery stenosis without either Williams or Alagille syndrome can successfully undergo surgical repair with a significant reduction in right ventricle-to-aortic pressure ratios.

    View details for DOI 10.1053/j.semtcvs.2020.01.003

    View details for PubMedID 31958550

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