Seda Tierney

Professor of Pediatrics (Cardiology)

Clinical Focus

Pediatric Cardiology
Echocardiography
Marfan Syndrome
Kawasaki Disease

Academic Appointments

Professor - University Medical Line, Pediatrics - Cardiology
Member, Cardiovascular Institute
Member, Maternal & Child Health Research Institute (MCHRI)

Administrative Appointments

Academic Affairs Lead, Pediatric Cardiology, Stanford University (2021 - Present)
Co-Director of Quality Improvement, Echo Laboratory, Lucile Packard Children’s Hospital, Stanford University (2021 - Present)
Director of Kawasaki Disease Outpatient Program, Heart Center, Lucile Packard Children’s Hospital, Stanford University (2021 - Present)
Co-Director, Stanford Pediatric Core Imaging and Translational Research (SPECTR) Laboratory, Stanford Children’s Health (2020 - Present)
Associate Professor of Pediatrics, Stanford University (2017 - Present)
Director of Research in the Non-Invasive Imaging Laboratory, Lucile Packard Children’s Hospital, Stanford University (2016 - Present)
Director of Pediatric Vascular Research Laboratory, Lucile Packard Children's Hospital, Stanford University (2011 - Present)
Assistant Professor of Pediatrics (Cardiology), Stanford School of Medicine (2011 - 2017)
Assistant Professor, Harvard School of Medicine (2009 - 2011)
Instructor in Pediatrics, Harvard School of Medicine (2004 - 2009)

Boards, Advisory Committees, Professional Organizations

Secretary, Board, Society of Pediatric Echocardiography (2022 - Present)
Member at Large, Pediatric Council, American Society of Echocardiography (2021 - Present)

Professional Education

Fellowship: Columbia University (2004) NY
Medical Education: Istanbul University CMF Medicine (1996) Turkey
Residency: SUNY - Stony Brook (2000) NY
Internship: SUNY - Stony Brook (1998) NY
Board Certification: American Board of Pediatrics, Pediatric Cardiology (2004)

Contact

Academic tierneys@stanford.edu

Clinical Heart Center 725 Welch Rd Ste 120 Palo Alto CA 94304 Tel: (650) 721-2121 Fax: (650) 497-8422

Current Research and Scholarly Interests

Assessment of vascular health in children by non-invasive modalities

Exercise interventions in children with congenital and acquired heart disease

Use of telehealth to deliver interventions to children with congenital and acquired heart disease

Parentally-acquired echocardiograms

Quality Improvement in Pediatric Echocardiography

Echocardiography and outcomes in congenital heart disease

Clinical Trials

Re-Energize Fontan Recruiting
More
Survival of children with single ventricles ("half a heart") beyond the neonatal period has increased dramatically with the staged Fontan palliation. Yet, long-term morbidity remains high. By the age of 40, 50% of Fontan patients will have died or undergone heart transplantation. With >1,000 Fontan palliations performed in the US annually, there is a burgeoning population of Fontan patients at risk for progressive heart failure and death. Factors that contribute to onset and progression of heart failure in Fontan patients remain incompletely understood. However, it is established that Fontan patients have poor exercise capacity, associated with a greater risk of morbidity and mortality, in addition to decreased muscle mass, abnormal muscle function, and endothelial dysfunction contributing to disease progression. In adult patients with two ventricles and heart failure, reduced exercise capacity, muscle mass, and muscle strength are powerful predictors of poor outcomes, and exercise interventions can not only improve exercise capacity and muscle mass, but also reverse endothelial dysfunction. Limited exercise interventions in children with congenital heart disease have demonstrated that exercise is safe and effective; however, these studies have been conducted in small, heterogeneous groups, and most had few Fontan patients. Furthermore, none of these interventions have studied the impact of exercise on muscle mass or mitochondrial function, or endothelial function. The investigators propose a milestone-driven, randomized controlled trial in pediatric Fontan patients to test the hypothesis that a live-video-supervised exercise (aerobic + resistance) intervention will improve cardiac and physical capacity; muscle mass, strength and function; and endothelial function. The investigators' ultimate goal is the translation of this model to clinical application as an "exercise prescription" to intervene early in pediatric Fontan patients and decrease long-term morbidity and mortality.

Lead Sponsor
- Stanford University
Stanford Investigators
- Seda Tierney
View full details
Children and Adolescents With Marfan Syndrome: 10,000 Healthy Steps and Beyond Not Recruiting
More
Marfan patients are at risk of sudden death due to weakening of the wall of the large blood vessel leading from the heart (aorta). The wall of the aorta weakens and dilates which can rupture, leading to death, and sometimes during intense exercise. There is some evidence in Marfan patients that a stiffer aorta increases risk for rupture. For some time, clinical care has focused on what type of exercise these patients should avoid due to risk for aortic dissection. Little clinical emphasis has been placed on encouraging patients to engage in routine and safe exercise such as walking. Informed by this evidence, the investigators propose to collaboratively investigate whether regular exercise improves aortic health in adolescent Marfan patients.

Stanford is currently not accepting patients for this trial. For more information, please contact Elif Seda M Selamet Tierney, 650-736-8716.

Lead Sponsor
- Stanford University
Stanford Investigators
- Seda Tierney
View full details
Tele-Clinic Visits in Pediatric Marfan Patients Using Parental Echo: The Future? Not Recruiting
More
Marfan syndrome (MFS), a connective tissue disorder seen in 1 in 3,000 individuals, causes progressive aortic root dilation that can result in aortic dissection and sudden death. Clinical care focuses on monitoring the aortic root by serial echocardiography (echo) to guide medical treatment and elective aortic root surgery in a specialized clinic every 6-12 months. This monitoring protocol, coupled with surgical intervention, has doubled the median life expectancy which was previously only 32 years. However, this surveillance carries significant health care costs at >$50 million dollars/year on echos alone (at $3-4K each) in children and adolescents in the US, as well as substantial burden on families residing far from specialized centers. A clinic visit delivered to MFS patients via live-video conferencing at home (tele-visit) could shift this paradigm, if a home echo could be obtained. Here, the investigator will train parents of Pediatric Marfan patients to take echo images using a hand held device, height, weight, blood pressure, medical history, and listen to the heart of their child. Then, the investigators will ask them to take the equipment home and collect the same data at home during a tele-clinic visit, with further instruction by the study team through secure live-video conferencing.

Stanford is currently not accepting patients for this trial. For more information, please contact Seda Tierney, MD, 650-724-9408.

Lead Sponsor
- Stanford University
Stanford Investigators
- Seda Tierney
View full details
On-Line Intervention to Lower Cardiovascular Risk in Pediatric Heart Transplant Patients Not Recruiting
More
Pediatric heart transplant patients have a high-risk cardiovascular profile affecting their long-term outcomes and survival. Currently, no effective cardiovascular preventative care is provided for this pediatric population, in part, due to the fact that clinic-based programs are not easily accessible to children and their families. However, tele-health has been show to improve medical outcomes by making care more accessible to these patients. This study aims to meet the urgent need for an effective and sustainable delivery of preventative care to pediatric heart transplant patients using a diet and exercise intervention program delivered live over the internet direct to these patients' homes.

Stanford is currently not accepting patients for this trial. For more information, please contact Elif Seda M Selamet Tierney, 650-736-8716.

Lead Sponsor
- Stanford University
Stanford Investigators
- Seda Tierney
View full details
Vascular Health and Exercise Performance of Overweight Children Not Recruiting
More
The purpose of this study is to assess exercise performance in 20 healthy children 10-19 years of age with a body mass index greater than 85th percentile and to evaluate the effect of dietary and exercise intervention over 12 weeks.

Stanford is currently not accepting patients for this trial. For more information, please contact Seda Tierney, MD, 650-736-7747.

Lead Sponsor
- Stanford University
Stanford Investigators
- Inger Olson
- Seda Tierney
View full details

2022-23 Courses

Independent Studies
- Directed Reading in Pediatrics
  PEDS 299 (Win, Spr)
- Early Clinical Experience
  PEDS 280 (Win, Spr)
- Graduate Research
  PEDS 399 (Win, Spr)
- Medical Scholars Research
  PEDS 370 (Win, Spr)
- Undergraduate Directed Reading/Research
  PEDS 199 (Win, Spr)

Stanford Advisees

Med Scholar Project Advisor
Riasoya Jodah

All Publications

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