Bio

Bio


A Sleep Research Professional with over 15 years of experience with a proven track record planning and implementing complex projects while ensuring that deliverables and milestones are met on time and within budget. Skilled at coordinating and overseeing complicated clinical research projects from start-up through study close-out, including final database lock, data analysis and manuscript preparation. Recognized for critical thinking, strategic and analytic skills as well as superb communication skills with study investigators, computer programmers, staff members and patients. Experienced in SAS statistical programming.

Current Role at Stanford


Project Director - Alliance Sleep Questionnaire (ASQ):
Oversee and manage creation, conversion to digital format and deployment of the Alliance Sleep Questionnaire (ASQ), an on-line questionnaire using complex branching logic.

Partner with stakeholders to design questionnaire content including documentation of deliverables and establishment of milestones and timelines.

Design and conduct pilot study for paper version of the ASQ at Stanford, including data acquisition, analysis, interpretation of results and publication of abstracts.

Manage digitization and deployment of ASQ, from creating a comprehensive data dictionary, developing validation mechanisms, beta testing, Epic integration, and incorporation of questionnaire into workflow at Stanford Sleep Clinic.

Support ASQ database, responsible for monitoring data acquisition and integrity, performing and analyzing QA/QC metrics, building queries and performing data analysis.

Work with supervisor to identify and execute related projects, such as creation of a dynamic Clinical Summary Report, an ASQ Outcomes Module and validation of the ASQ.


Data Administrator
Design and manage creation of complex database system for the Stanford Sleep Cohort. Involves providing technical expertise to create a data management system to link clinical and research data using a universal ID to improve data security and operational effectiveness.

Provide statistical support using SAS for projects within area of responsibility.

Assist with new grant applications. Involves partnering with Principal Investigator and key lab members to document background, rational and study design using appropriate format and mechanism for the funding agencies.

Write and edit manuscripts for publication in scientific journals.


Webmaster:
Assemble and coordinate task-force to create and deploy new websites for the Stanford Center for Sleep Sciences and Medicine, Stanford Sleep Medicine Center, and Stanford Center for Narcolepsy. Includes formulation and articulation of project goals, milestones, timeline and strategy for content development as well as writing original content for the website.

Education & Certifications


  • MS, Stanford University School of Medicine, Epidemiology (2013)
  • RPSGT, Board of Registered Polysomnographic Technologists, Sleep Technologist #2157 (1998)
  • RST, American Board of Sleep Medicine, Registered Sleep Technologist #2791 (2012)

Publications

Journal Articles


  • Effects of Continuous Positive Airway Pressure on Neurocognitive Function in Obstructive Sleep Apnea Patients: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) SLEEP Kushida, C. A., Nichols, D. A., Holmes, T. H., Quan, S. F., Walsh, J. K., Gottlieb, D. J., Simon, R. D., Guilleminault, C., White, D. P., Goodwin, J. L., Schweitzer, P. K., Leary, E. B., Hyde, P. R., Hirshkowitz, M., Green, S., McEvoy, L. K., Chan, C., Gevins, A., Kay, G. G., Bloch, D. A., Crabtree, T., Dement, W. C. 2012; 35 (12): 1593-U40

    Abstract

    To determine the neurocognitive effects of continuous positive airway pressure (CPAP) therapy on patients with obstructive sleep apnea (OSA).The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blind, 2-arm, sham-controlled, multicenter trial conducted at 5 U.S. university, hospital, or private practices. Of 1,516 participants enrolled, 1,105 were randomized, and 1,098 participants diagnosed with OSA contributed to the analysis of the primary outcome measures.Active or sham CPAP MEASUREMENTS: THREE NEUROCOGNITIVE VARIABLES, EACH REPRESENTING A NEUROCOGNITIVE DOMAIN: Pathfinder Number Test-Total Time (attention and psychomotor function [A/P]), Buschke Selective Reminding Test-Sum Recall (learning and memory [L/M]), and Sustained Working Memory Test-Overall Mid-Day Score (executive and frontal-lobe function [E/F])The primary neurocognitive analyses showed a difference between groups for only the E/F variable at the 2 month CPAP visit, but no difference at the 6 month CPAP visit or for the A/P or L/M variables at either the 2 or 6 month visits. When stratified by measures of OSA severity (AHI or oxygen saturation parameters), the primary E/F variable and one secondary E/F neurocognitive variable revealed transient differences between study arms for those with the most severe OSA. Participants in the active CPAP group had a significantly greater ability to remain awake whether measured subjectively by the Epworth Sleepiness Scale or objectively by the maintenance of wakefulness test.CPAP treatment improved both subjectively and objectively measured sleepiness, especially in individuals with severe OSA (AHI > 30). CPAP use resulted in mild, transient improvement in the most sensitive measures of executive and frontal-lobe function for those with severe disease, which suggests the existence of a complex OSA-neurocognitive relationship.Registered at clinicaltrials.gov. Identifier: NCT00051363. CITATION: Kushida CA; Nichols DA; Holmes TH; Quan SF; Walsh JK; Gottlieb DJ; Simon RD; Guilleminault C; White DP; Goodwin JL; Schweitzer PK; Leary EB; Hyde PR; Hirshkowitz M; Green S; McEvoy LK; Chan C; Gevins A; Kay GG; Bloch DA; Crabtree T; Demen WC. Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: the Apnea Positive Pressure Long-term Efficacy Study (APPLES). SLEEP 2012;35(12):1593-1602.

    View details for DOI 10.5665/sleep.2226

    View details for Web of Science ID 000313000600005

    View details for PubMedID 23204602

  • The Association between Obstructive Sleep Apnea and Neurocognitive Performance-The Apnea Positive Pressure Long-term Efficacy Study (APPLES) SLEEP Quan, S. F., Chan, C. S., Dement, W. C., Gevins, A., Goodwin, J. L., Gottlieb, D. J., Green, S., Guilleminault, C., Hirshkowitz, M., Hyde, P. R., Kay, G. G., Leary, E. B., Nichols, D. A., Schweitzer, P. K., Simon, R. D., Walsh, J. K., Kushida, C. A. 2011; 34 (3): 303-U207

    Abstract

    To determine associations between obstructive sleep apnea (OSA) and neurocognitive performance in a large cohort of adults.Cross-sectional analyses of polysomnographic and neurocognitive data from 1204 adult participants with a clinical diagnosis of obstructive sleep apnea (OSA) in the Apnea Positive Pressure Long-term Efficacy Study (APPLES), assessed at baseline before randomization to either continuous positive airway pressure (CPAP) or sham CPAP.Sleep and respiratory indices obtained by laboratory polysomnography and several measures of neurocognitive performance.Weak correlations were found for both the apnea hypopnea index (AHI) and several indices of oxygen desaturation and neurocognitive performance in unadjusted analyses. After adjustment for level of education, ethnicity, and gender, there was no association between the AHI and neurocognitive performance. However, severity of oxygen desaturation was weakly associated with worse neurocognitive performance on some measures of intelligence, attention, and processing speed.The impact of OSA on neurocognitive performance is small for many individuals with this condition and is most related to the severity of hypoxemia.

    View details for Web of Science ID 000287917600010

    View details for PubMedID 21358847

  • The Apnea Positive Pressure Long-term Efficacy Study (APPLES): rationale, design, methods, and procedures. Journal of clinical sleep medicine Kushida, C. A., Nichols, D. A., Quan, S. F., Goodwin, J. L., White, D. P., Gottlieb, D. J., Walsh, J. K., Schweitzer, P. K., Guilleminault, C., Simon, R. D., Leary, E. B., Hyde, P. R., Holmes, T. H., Bloch, D. A., Green, S., McEvoy, L. K., Gevins, A., Dement, W. C. 2006; 2 (3): 288-300

    Abstract

    To assess the size, time course, and durability of the effects of long-term continuous positive airway pressure (CPAP) therapy on neurocognitive function, mood, sleepiness, and quality of life in patients with obstructive sleep apnea.Randomized, double-blinded, 2-arm, sham-controlled, multicenter, long-term, intention-to-treat trial of CPAP therapy.Sleep clinics and laboratories at 5 university medical centers and community-based hospitals. Patients or Participants: Target enrollment is 1100 randomly assigned subjects across 5 clinical centers.Active versus sham (subtherapeutic) CPAP. Measurements and Results: A battery of conventional and novel tests designed to evaluate neurocognitive function, mood, sleepiness, and quality of life.The Apnea Positive Pressure Long-term Efficacy Study (APPLES) is designed to study obstructive sleep apnea and test the effects of CPAP through a comprehensive, controlled, and long-term trial in a large sample of subjects with obstructive sleep apnea.

    View details for PubMedID 17561541

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