Djenet Bousbaine

Postdoctoral Scholar, Bioengineering

Professional Education

Doctor of Philosophy, Massachusetts Institute of Technology, Microbiology (2020)
Master of Science, Swiss Federal Institute of Technology (EPFL), Life Sciences and technologies (2012)
Bachelor of Science, Swiss Federal Institute of Technology (EPFL), Life Sciences and technologies (2010)

All Publications

Profiles With Related Publications

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Gita Chu Abhiraman

MD Student, expected graduation Spring 2023 Ph.D. Student in Immunology, admitted Autumn 2020 MSTP Student

2 Total Publications
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Matthew Bogyo

Professor of Pathology and of Microbiology and Immunology and, by courtesy, of Chemical and Systems Biology
Research Interests
Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include:

1) Design and synthesis of novel chemical probes for serine and cysteine hydrolases.

2) Understanding the role of hydrolases in bacterial pathogenesis and the human parasites, Plasmodium falciparum and Toxoplasma gondii.

3) Defining the specific functional roles of proteases during the process of tumorogenesis.

4) In vivo imaging of protease activity

350 Total Publications
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Yueh-hsiu Chien

Professor of Microbiology & Immunology
Research Interests
Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.

106 Total Publications
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Edgar Engleman

Professor of Pathology and of Medicine (Immunology and Rheumatology)
Research Interests
Dendritic cells, macrophages, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer, autoimmune disease, neurodegenerative disease and metabolic disease.

286 Total Publications
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C. Garrison Fathman

Professor of Medicine (Immunology and Rheumatology), Emeritus
Research Interests
My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We have identified and characterized a gene (GRAIL) that seems to control regulatory T cell (Treg) responsiveness by inhibiting the Treg IL-2 receptor desensitization. We have characterized a gene (Deaf1) that plays a major role in peripheral tolerance in T1D. Using PBC gene expression, we have provisionally identified a signature of risk and progression in T1D.

326 Total Publications
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Chris Garcia

Younger Family Professor and Professor of Structural Biology
Research Interests
Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.

275 Total Publications
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Melanie Hannebelle

Postdoctoral Scholar, Bioengineering

11 Total Publications
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Patricia Jones

The Dr. Nancy Chang Professor, Emerita
Research Interests
Dr. Jones' research has focused on genetic, molecular, and cellular mechanisms that regulate immune responses. Recent work was centered on the regulation of innate immune responses that are triggered by conserved microbial components. As these responses can be harmful they are highly regulated in their occurrence, magnitude, and duration. Her lab discovered a novel mechanism that negatively regulates innate responses, mediated by the phosphatase calcineurin.

31 Total Publications
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Ronald Levy, MD

Robert K. and Helen K. Summy Professor in the School of Medicine
Clinical Focus
Cancer > Lymphoma, Lymphoma , Non-Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma - Medical Oncology, Burkitt's Lymphoma, Burkitt's Lymphoma - Medical Oncology, Hodgkin's Disease, Hodgkin's Disease - Medical Oncology, Burkitt's Lymphoma - Hematology, Hodgkin's Disease - Hematology, Oncology (Cancer), Non-Hodgkin's Lymphoma - Hematology, Medical Oncology
Research Interests
Clinical Interests: lymphoma. Research Interests: Immunology and molecular biology of lymphoid malignancy; molecular vaccines for cancer.

414 Total Publications
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David B. Lewis

Naddisy Foundation Professor of Pediatric Food Allergy, Immunology, and Asthma
Clinical Focus
Primary Immunodeficiency, Pediatrics
Research Interests
My laboratory is focused on defining cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. We are also determinomg how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants for influenza vaccine and by using catalytically inactive Cas proteins for inducing endogenous gene expression.

174 Total Publications
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Crystal Mackall

Ernest and Amelia Gallo Family Professor and Professor of Pediatrics and of Medicine
Clinical Focus
Pediatric Hematology-Oncology
Research Interests
Recent clinical studies, by us and others, have demonstrated that genetically engineered T cells can eradicate cancers resistant to all other therapies. We are identifying new targets for these therapeutics, exploring pathways of resistance to current cell therapies and creating next generation platforms to overcome therapeutic resistance. We have discovered novel insights into the biology of human T cell exhaustion and developed approaches to prevent and reverse this phenomenon.

342 Total Publications
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Holden Maecker

Professor (Research) of Microbiology and Immunology
Research Interests
I'm interested in immune monitoring of T cell responses to chronic pathogens and cancer, and the correlation of T cell response signatures with disease protection.

162 Total Publications