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  • The developing premature infant gut microbiome is a major factor shaping the microbiome of neonatal intensive care unit rooms MICROBIOME Brooks, B., Olm, M. R., Firek, B. A., Baker, R., Geller-McGrath, D., Reimer, S. R., Soenjoyo, K. R., Yip, J. S., Dahan, D., Thomas, B. C., Morowitz, M. J., Bonfield, J. F. 2018; 6: 112

    Abstract

    The neonatal intensive care unit (NICU) contains a unique cohort of patients with underdeveloped immune systems and nascent microbiome communities. Patients often spend several months in the same room, and it has been previously shown that the gut microbiomes of these infants often resemble the microbes found in the NICU. Little is known, however, about the identity, persistence, and absolute abundance of NICU room-associated bacteria over long stretches of time. Here, we couple droplet digital PCR (ddPCR), 16S rRNA gene surveys, and recently published metagenomics data from infant gut samples to infer the extent to which the NICU microbiome is shaped by its room occupants.Over 2832 swabs, wipes, and air samples were collected from 16 private-style NICU rooms housing very low birth weight (

    View details for PubMedID 29925423

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