Dennis Lund

All Publications

• Implications of the 21st Century Cures Act in Pediatrics. Pediatrics Pageler, N. M., Webber, E. C., Lund, D. 2020

  View details for DOI 10.1542/peds.2020-034199

  View details for PubMedID 33293349

• High prevalence of same-sex twins in patients with cloacal exstrophy: Support for embryological association with monozygotic twinning Fullerton, B. S., Sparks, E. A., Hall, A. M., Velazco, C. S., Modi, B. P., Lund, D. P., Jaksic, T., Hendren, W. W B SAUNDERS CO-ELSEVIER INC. 2017: 807–9

  Abstract

  Previous studies have hypothesized that cloacal exstrophy may be caused by errors early in embryological development related to monozygotic twinning. This study reports the prevalence of twins in a large cohort of patients with cloacal exstrophy.Patients with cloacal exstrophy treated 1974-2015 were reviewed for reports of multiple gestation or conjoined twinning. The genetic sex of the patient and their twin, and any mention of anomaly in the twin were recorded. Neither placental exam nor genetic testing results were available to definitively determine zygosity.Of 71 patients, 10 had a live born twin (14%), all of whom were of the same genetic sex as the affected patient. One additional patient's twin suffered intrauterine fetal demise, and another patient had a conjoined heteropagus twin. None of the twins were affected by exstrophy-epispadias complex. The rate of twin birth in this cohort was 4.4-7.7 higher than that reported by the Centers for Disease Control in the general population time period (P<0.001), with a striking preponderance of same-sex pairs.The highly significant prevalence of same-sex twin pairs within this cohort supports the hypothesis that the embryogenesis of cloacal exstrophy may be related to errors in monozygotic twinning.2b.

  View details for PubMedID 28202184

• Understanding the Operative Experience of the Practicing Pediatric Surgeon Implications for Training and Maintaining Competency JAMA SURGERY Abdullah, F., Salazar, J. H., Gause, C. D., Gadepalli, S., Biester, T. W., Azarow, K. S., Brandt, M. L., Chung, D. H., Lund, D. P., Rescorla, F. J., Waldhausen, J. H., Tracy, T. F., Fallat, M. E., Klein, M. D., Lewis, F. R., Hirschl, R. B. 2016; 151 (8): 735-741

  Abstract

  The number of practicing pediatric surgeons has increased rapidly in the past 4 decades, without a significant increase in the incidence of rare diseases specific to the field. Maintenance of competency in the index procedures for these rare diseases is essential to the future of the profession.To describe the demographic characteristics and operative experiences of practicing pediatric surgeons using Pediatric Surgery Board recertification case log data.We performed a retrospective review of 5 years of pediatric surgery certification renewal applications submitted to the Pediatric Surgery Board between 2009 and 2013. A surgeon's location was defined by population as urban, large rural, small rural, or isolated. Case log data were examined to determine case volume by category and type of procedures. Surgeons were categorized according to recertification at 10, 20, or 30 years.Number of index cases during the preceding year.Of 308 recertifying pediatric surgeons, 249 (80.8%) were men, and 143 (46.4%) were 46 to 55 years of age. Most of the pediatric surgeons (304 of 308 [98.7%]) practiced in urban areas (ie, with a population >50 000 people). All recertifying applicants were clinically active. An appendectomy was the most commonly performed procedure (with a mean [SD] number of 49.3 [35.0] procedures per year), nonoperative trauma management came in second (with 20.0 [33.0] procedures per year), and inguinal hernia repair for children younger than 6 months of age came in third (with 14.7 [13.8] procedures per year). In 6 of 10 "rare" pediatric surgery cases, the mean number of procedures was less than 2. Of 308 surgeons, 193 (62.7%) had performed a neuroblastoma resection, 170 (55.2%) a kidney tumor resection, and 123 (39.9%) an operation to treat biliary atresia or choledochal cyst in the preceding year. Laparoscopy was more frequently performed in the 10-year recertification group for Nissen fundoplication, appendectomy, splenectomy, gastrostomy/jejunostomy, orchidopexy, and cholecystectomy (P < .05) but not lung resection (P = .70). It was more frequently used by surgeons recertifying in the 10-year group (used in 11 375 of 14 456 procedures [78.7%]) than by surgeons recertifying in the 20-year (used in 6214 of 8712 procedures [71.3%]) or 30-year group (used in 2022 of 3805 procedures [53.1%]).Practicing pediatric surgeons receive limited exposure to index cases after training. With regard to maintaining competency in an era in which health care outcomes have become increasingly important, these results are concerning.

  View details for DOI 10.1001/jamasurg.2016.0261

  View details for PubMedID 27027471

• Growth morbidity in patients with cloacal exstrophy: a 42-year experience Fullerton, B. S., Sparks, E. A., Hall, A. M., Chan, Y., Duggan, C., Lund, D. P., Modi, B. P., Jaksic, T., Hendren, W. W B SAUNDERS CO-ELSEVIER INC. 2016: 1017–21

  Abstract

  Cloacal exstrophy is associated with multiple comorbidities that affect growth. This report describes long-term growth outcomes in a large cohort of patients with cloacal exstrophy and explores associated comorbidities.Records of 71 patients with cloacal exstrophy who were treated between 1974 and 2015 were reviewed, and 62 patients with growth data from 2 to 20years of age were included. Genetic sex, gender of rearing, and all heights, weights, and comorbidities were noted for each patient. Height-for-age, weight-for-age, and body mass index z-scores (HAZ, WAZ, and BMIZ) were determined using US Centers for Disease Control 2000 growth data, and average patient z-scores were calculated.There were 904 height and 1301 weight measurements available for 62 patients. 31 were genetically 46,XY, 21 of whom underwent gonadectomy in infancy and were raised female. 46,XX patients, 46,XY male patients, and 46,XY female patients all had median HAZ and WAZ substantially lower than the general population, with median HAZ less than -2, while maintaining normal BMIZ. Short bowel syndrome and enterocystoplasty with intestine were associated with lower z-scores for all parameters.Patients with cloacal exstrophy have significant multifactorial long-term growth failure. These benchmark data can be used to further optimize management.2b.

  View details for DOI 10.1016/j.jpedsurg.2016.02.075

  View details for Web of Science ID 000378908600030

  View details for PubMedID 27114306

  View details for PubMedCentralID PMC4921257