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Member, Wu Tsai Neurosciences Institute
Wu Tsai Neurosciences Institute
Senior Scientific Officer, Howard Hughes Medical Institute (2004 - 2005)
Jury Member, Lasker Awards (1999 - 2000)
Medical Advisory Board, Howard Hughes Medical Institute (1998 - 2001)
Scientific Advisory Board, Howard Hughes Medical Institute (1997 - 1998)
Chairman, Department of Neurobiology (1992 - 1995)
Honors & Awards
Foreign Member, Royal Society of London (2003)
Member, National Academy of Sciences, USA (1993)
Fellow, American Academy of Arts and Sciences (1992)
M.D., Yale Medical School, Medicine (1965)
Curriculum Vitae DOC
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Profiles With Related Publications
Timothy Angelotti MD, PhD
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD)
Critical Care, Anesthesia
My research efforts are focused on investigating the pharmacological and physiological interface of the autonomic nervous system with effector organs. Utilizing molecular, cellular, and electrophysiological techniques, we are examining alpha2 adrenergic receptor function in cultured sympathetic neurons. Future research aims will be directed toward understanding neurotransmitter release in general.
Stephen A. Baccus
Professor of Neurobiology
We study how the neural circuitry of the vertebrate retina encodes visual information and performs computations. To control and measure the retinal circuit, we present visual images while performing simultaneous two-photon imaging and multielectrode recording. We perturb the circuit as it operates using simultaneous intracellular current injection and multielectrode recording, and use the resulting large data sets to construct models of retinal computation.
John R. Adler Professor, Professor of Neurosurgery and of Ophthalmology and, by courtesy, of Electrical Engineering
Functional circuitry of the retina and design of retinal prostheses
Postdoctoral Scholar, Bioengineering
Assistant Professor of Neurobiology, of Psychiatry and Behavioral Sciences and, by courtesy, of Electrical Engineering
Our research goal is to understand how dynamics in neuronal circuits relate and constrain the representation of information and computations upon it. We adopt three synergistic strategies: First, we analyze neural circuit population recordings to better understand the relation between neural dynamics and behavior, Second, we theoretically explore the types of dynamics that could be associated with particular network computations. Third, we analyze the structural properties of neural circuits.
Miriam B. Goodman
Mrs. George A. Winzer Professor of Cell Biology
We study the molecular events that give rise to the sensation of touch and temperature in C. elegans. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. We also collaborate with Pruitt's group in Mechanical Engineering to develop and fabricate novel devices for the study of sensory transduction.
Shaul Hestrin, PhD
Professor of Comparative Medicine
The main interest of my lab is to understand how the properties of neocortical neurons, the circuits they form and the inputs they receive give rise to neuronal activity and behavior. Our approach includes behavioral studies, two-photon calcium imaging, in vivo whole cell recording in behaving animals and optogenetic methods to activate or to silence the activity of cortical neurons.
Andrew D. Huberman
Associate Professor of Neurobiology and, by courtesy, of Psychiatry and Behavioral Sciences
1) We study neural regeneration with the goal of developing treatments to prevent and reverse vision loss. (e.g., Huberman, Nature 2020; Laha and Huberman, Science, 2017; Lim et al., Nature Neuroscience, 2016).
2) We are parsing the neural circuits for anxiety, and visually-driven autonomic arousal, (e.g., Salay et al., Nature, 2018; Yilmaz-Balban et al., Current Biology, 2021).
Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology
We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks.
Bruce Koch, Ph.D.
Director, High-Throughput Screening
Eline R Kupers
Postdoctoral Scholar, Psychology
Professor of Molecular and Cellular Physiology
We study molecular mechanisms of calcium signaling with a focus on store-operated CRAC channels and their essential roles in T cell development and function. Currently we aim to define the molecular mechanism for CRAC channel activation and the means by which calcium signal dynamics mediate specific activation of transcription factors and T-cell genes during development.
Publication Topics For This Person
Dose-Response Relationship, Radiation
Retinal Ganglion Cells
Retinal Rod Photoreceptor Cells
Rod Cell Outer Segment