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Deputy Director, Center for Cancer Nanotechnology Excellence for Translational Diagnostics
Stanford, CA, USA
RESEARCH INTERESTS* Biological Engineering and Micro/Nanomedicine *- Chip-based biomedical micro and nano-integrated systems for sensing, diagnosis, and therapy; micro and nano-scale biosensors for cells, proteins, DNA- Biomimetically Inspired Engineered Systems- Biosensors, Intelligent Medical Devices utilizing machine learning, artificial intelligence and expert systems to improve functionality and performance- Polymer-based microfludic and silicon micromachined chips for infectious agent detection and re-emerging diseases- Single molecule imaging and image analysis to study cell:pathogen interactions, molecular beacons for intracellular gene expression analysis, Atomic Force Microscopy, study of viral capsid biomechanics and assembly- Microbial and cellular engineering for Cancer applications- Stimuli responsive polymers such as hydrogels for development of micro/nano-devices for drug delivery and biomedical sensing applications.- Wireless Passive Theranostic Devices for medical monitoring and intervention* Genomics/Systems Biology *- Reverse Engineering of Signal Transduction Networks and Molecular Pathways: SilicoCyte, Virtual Cellular communities- Applications of genomics and bioinformatics in molecular profiling of cancer. Identification of predictive tumor markers and anti-cancer small molecule drug leads.- Artificial intelligence-based collaborative software development for Systems Biology: Fuzzy logic, Neural Nets, Genetic Algorithms, Expert Systems, Pattern Finding, Data Warehousing* Gene Therapy/Microbiology/Virology *- Microbial and cellular engineering- Experimental Therapeutics and Diagnostics: Endogenously (Self)-Regulated Gene Therapy; Cellular Re-programming, Therapeutic Transgenics, Correction of genetic defects by via gene replacement- Molecular basis of disease resistance , susceptibility and coordinated gene regulation. Enhancement of disease resistance via manipulation of host immune components, DNA vaccines and therapeutic modulation of signal transduction pathways by small molecule drugs - Prediction and computational modeling of genome evolution of RNA viruses (Coronaviridae, influenza). Forced evolution of viruses and emergence of new strains or quasi-species formation- MEMS and Nano-based Biosensors for detection and continious monitoring of airborne biothreat agents