I have over 20 years of experience in both Biotech and Academia running High-Throughput Screening labs. Since its inception in 2003, I have been running the Stanford University High-Throughput Bioscience Center (HTBC), whose mission is to provide researchers with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTBC is a Stanford University School of Medicine core facility and was created by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTBC is also a shared resource for the Stanford Cancer Institute. The HTBC has the capability to run fully automated high-throughput screens for both cell-based and enzyme/protein based screens and even can run fully automated high-content screens. I manage all the day-to-day operations of the HTBC including acting as project manager for all screens, maintaining the databases and servers, experimental design, development, validation and testing, robotic programming, and all decision making on major instrumentation purchases as well as all financial matters. Under my leadership, projects performed in the HTBC have resulted in over 85 publications, dozens of patent applications, and a few start up Biotech companies. Discoveries in the HTBC have also been featured on NPR and on the front page of the San Francisco Chronicle.
Expertise: High-Throughput Screening, Drug Discovery, Assay Development, siRNA Screening, High-Content Screening, Data Analysis, Cheminformatics
Current Role at Stanford
Director, High-Throughput Bioscience Center
The High-Throughput Bioscience Center's mission is to provide researchers at Stanford with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTBC is a Stanford University School of Medicine core facility and was created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTBC is a shared resource (Bioscience Screening Facility) for the Stanford Cancer Institute (more info), the Digestive Disease Center (Chemical Genomics Core), and the NIH Clinical and Translational Science Award (Spectrum).
Research approaches that were previously done exclusively in industry are now being used in academia to advance basic research. This high-throughput screening (HTS) laboratory allows Stanford researchers and others to discover novel modulators of targets that otherwise would not be practical in industry. The center incorporates instrumentation (purchased with NCRR NIH Instrumentation grant numbers S10RR019513 and S10RR026338), databases, compound libraries, and personnel whose previous sole domains were in industry. Among our instrumentation are a Molecular Devices ImageXpress Micro High-Content fluorescence microplate imager, with live cell and phase contrast/brightfield options, a Caliper Life Sciences SciClone ALH3000 and an Agilent Bravo microplate liquid handler, and the Molecular Devices Analyst GT and FlexStation II 384 and Tecan Infinite M1000 PRO fluorescence, luminescence and absorbance multimode microplate readers. We have over 135,000 small molecules for compound screens, 15,000 cDNAs for genomic screens, and the siARRAY whole human genome siRNA library from ThermoFisher Scientific (formerly Dharmacon) targeting 21,000 genes.
The HTBC is located in CCSR Room 0133-North Wing, between the Transgenic Mouse Facility, the Immune Monitoring Core, and the Stanford Functional Genomics Facility.
Member, Stanford Cancer Institute
Honors & Awards
University Fellowship, University of California at Berkeley (1991-1992)
National Hispanic Scholar, MIT (1986-1987)
Education & Certifications
PhD, University of California, Berkeley, Molecular and Cellular Biology (1995)
BS, MIT, Applied Biology (1990)
C Chan, SS Gambhir, DE Solow-Cordero, A Hoehne, R Paulmurugan. "United States Patent US Patent App. 13/898,637 Multi-modality molecular imaging high-throughput assay for identifying heat shock protein 90 (hsp90) inhibitors.", Leland Stanford Junior University
Edda SPIEKERKOETTER, Marlene RABINOVITCH, Philip BEACHY, David SOLOW-CORDERO,. "United States Patent 2012151153 USE OF FK506 FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION", THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSIT, Aug 11, 2012
David Solow-cordero, Geetha Shankar, Charles Gluchowski, Juliet V Spencer,. "United States Patent EP Patent 1,523,556, 2005 METHODS OF TREATING CONDITIONS ASSOCIATED WITH AN EDG-1 RECEPTOR", Apr 20, 2005
Geetha Shankar, David Solow-cordero, Juliet V Spencer, Charles Gluchowski,. "United States Patent EP Patent 1,513,522, 2005 METHODS OF TREATING CONDITIONS ASSOCIATED WITH AN EDG RECEPTOR", Mar 16, 2005
David SOLOW-CORDERO, Geetha SHANKAR, Charles GLUCHOWSKI, Juliet SPENCER,. "United States Patent WO Patent 2,004,009,816 METHODS OF TREATING CONDITIONS ASSOCIATED WITH AN EDG-1 RECEPTOR", Jan 30, 2004
Geetha SHANKAR, David SOLOW-CORDERO, Juliet SPENCER, Charles GLUCHOWSKI,. "United States Patent WO Patent 2,003,062,392 METHODS OF TREATING CONDITIONS ASSOCIATED WITH AN EDG RECEPTOR", Aug 1, 2003