Bio
Crystal L Mackall MD is the Ernest and Amelia Gallo Family Professor and Professor of Pediatrics and Medicine at Stanford University, the Founding Director of the Stanford Center for Cancer Cell Therapy, Associate Director of the Stanford Cancer Institute, Leader of the Cancer Immunotherapy Program and Director of the Parker Institute for Cancer Immunotherapy @ Stanford. During a 27-year tenure at NCI culminating as Chief of the Pediatric Oncology Branch and Head of the Immunology Section and since 2016 at Stanford, she has led an internationally recognized translational research program focused on immune-oncology. Her work has advanced understanding of fundamental immunology and translated this understanding for the treatment of human disease with a major focus on children’s cancers. She has led numerous first-in-human and first-in-child clinical trials spanning dendritic cell vaccines, cytokines, and adoptive immunotherapy using NK cells and genetically modified T cells. Her work is credited with identifying an essential role for the thymus in human T cell regeneration (NEJM 1995) and discovering IL-7 as the master regulator of T cell homeostasis (Blood 2001, J Exp Med 2008). Her group was among the first to demonstrate impressive activity of CD19-CAR in pediatric leukemia (Lancet 2015), developed a CD22-CAR that is the only active salvage therapy for CAR19 resistant B cell malignancies (Nat Med 2018, J Clin Onc 2020, Blood 2021, Lancet 2024), demonstrated preclinical activity of GD2 targeting CARs for pediatric diffuse intrinsic pontine glioma (Nat Med 2018), demonstrated superiority of regional CNS delivery of CAR T cells for brain tumors (Nat Med 2020) and demonstrated impressive clinical activity of GD2-CAR T cells in this disease (NCT04196413), which is among the first to demonstrate significant and consistent activity of CAR T cells in solid cancers (Nature 2022, Nature 2024). Her group identified T cell exhaustion as a major feature CAR T cell potency (Nat Med 2015), created the first exhaustion-resistance (Nature 2019) and exhaustion-reversal platforms (Science 2021), discovered a role for mediator kinase in regulating T cell differentiation (Science 2022) and a role for FOXO1 in regulating T cell memory (Nature 2024). Her group recently implicated macrophage mediated clearance of activated T cells in resistance to cell therapies and created an engineered CD47 to overcome this axis (Nature 2024). Mackall's group also uses synthetic biology to engineer safer and more effective cellular therapeutics, including creation of a best-in-class regulatable “remote-controlled” CAR T cell platform (Cell, 2022) and multiplex gene regulation using Cas13d based RNA degradation. She has received numerous awards, including election to the National Academy of Medicine, American Society of Clinical Investigation and American Academy of Physicians, and she is a fellow of the AACR Academy and the Academy of Immuno-oncology. She received Smalley Award for outstanding contributions to cancer immunotherapy from the Society for the Immunotherapy of Cancer, the AACR-St.Baldrick’s Distinguished Achievement Award for Pediatric Cancer Research, the Nobility in Science Award from the Sarcoma Foundation of America and the Edward Netter Leadership Award from the Alliance for Cancer Gene Therapy. She has published over 300 manuscripts and her h-index in December 2024 according to google scholar was 113. She has co-founded 3 biotech companies: Lyell Immunopharma, CARGO Therapeutics and Link Cell Therapies.
