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We are interested in finding new strategies to promote neuronal survival and improve functional outcome following injury to the brain. The brain consists of several different cell types, the most abundant of which are astrocytes, specialized glial cells that play a vital role in regulating neuronal function and homeostasis. Specifically, we are focused on determining the role of non-coding RNA's in: 1) astrocyte-meadited protection and recovery of brain function following ischemic injury, and; 2) gender differences in severity of injury and recovery from stroke.