Bio

Clinical Focus


  • Pediatric Hematology-Oncology

Academic Appointments


Administrative Appointments


  • Co-Ambulatory Medical Director, Bass Center for Childhood Cancer and Blood Diseases (2017 - Present)
  • Section Chief, Pediatric Hematology (2017 - Present)
  • Medical Director, Pediatric Hematology (2016 - Present)
  • Clerkship Director, Pediatric Hematology-Oncology Medical School Clerkship (Peds 305A) (2014 - Present)
  • Rotation Director, Pediatric Hematology Residency Selective (2013 - Present)
  • Undergraduate Pre-Major Advisor, Stanford University (2013 - Present)

Honors & Awards


  • Member, Alpha Omega Alpha
  • Awardee, Stanford SPARK (2013)
  • Awardee, Child Health Research Institute Grant (2012)
  • Awardee, Stanford Pediatric Research Fund (2011)
  • Awardee, Helena Anna Henzl Gabor Young Women in Science Fellowship (2010)
  • Fellow, Debra and Andrew Rachleff Endowed Fellow (2009-2011)
  • Fellow, Krensky Endowed Clinical Fellow (2008-2009)
  • Awardee, Children's Hospital of Orange County Merle J. Norman Graduating Resident of the Year (2008)
  • Awardee, Childrens Hospital of Orange County Resident Teaching Award (2007)
  • Awardee, Regents Scholar (2001)

Boards, Advisory Committees, Professional Organizations


  • Member, International Society on Thrombosis and Haemostasis (2015 - Present)
  • Member, Intern Selection Committee (2014 - Present)
  • Committee Member, ITP Consortium of North America (2012 - Present)
  • Member, American Society of Hematology (2008 - Present)
  • Member, American Society of Pediatric Hematology/Oncology (2008 - Present)

Professional Education


  • Fellowship:Stanford University Pediatric Hematology Oncology Fellowship (2011) CA
  • Residency:UCI at Children's Hospital Orange County Pediatric Residency (2008) CA
  • Medical Education:New York Medical College Registrar (2005) NY
  • Board Certification: Pediatric Hematology-Oncology, American Board of Pediatrics (2013)
  • Board Certification: Pediatrics, American Board of Pediatrics (2008)

Research & Scholarship

Current Research and Scholarly Interests


Research interests include:
Biomarkers and targeted therapy in pediatric immune thrombocytopenia
Transfusion-related iron overload
Hemophilia and other rare bleeding disorders
Thrombophilia

Publications

All Publications


  • Usefulness of anti-platelet therapy testing in children supported with a ventricular assist device JOURNAL OF HEART AND LUNG TRANSPLANTATION May, L. J., Liu, X., Tesoro, T., Yang, J., Lo, C., Chen, S., Murray, J., Rosenthal, D. N., Massicotte, P., Michelson, A. D., Almond, C. S. 2019; 38 (7): 781–83
  • Usefulness of anti-platelet therapy testing in children supported with a ventricular assist device. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation May, L. J., Liu, X., Tesoro, T., Yang, J., Lo, C., Chen, S., Murray, J., Rosenthal, D. N., Michelson, A. D., Almond, C. S. 2019

    View details for PubMedID 31006520

  • Platelet Characteristics and Bleeding Patterns in Children with Jacobsen Syndrome: A Single Center Report Gilbert, M., Lo, C., Andrews, J., Ohgami, R., Jeng, M. WILEY. 2017: S86
  • Case Report: Clinical Variation in Children With Thrombopoietin Receptor (C-MPL) Mutations: Report of 2 Cases. Journal of pediatric hematology/oncology Lo, C., Alvarez, E., Ohgami, R. S., Jeng, M. 2017

    Abstract

    Congenital amegakaryocytic thrombocytopenia (CAMT, MIM# 604498) is a rare congenital bone marrow failure syndrome which presents early in life with abnormal bleeding because of thrombocytopenia. Classically, megakaryocytes are decreased to absent in the bone marrow. The development of aplastic anemia early in childhood has led to the recommendation for early stem cell transplantation. Quantitative or loss-of-function mutations in the myeloproliferative leukemia gene (c-mpl), whose gene product functions as the thrombopoietin receptor, have been identified as causative for CAMT. Approximately 100 cases of CAMT are published in the medical literature. We describe 2 cases of CAMT who demonstrate disparate clinical courses, thereby highlighting phenotypic differences and increasing awareness of this clinical entity.

    View details for PubMedID 28859041

  • Major Causes of Stroke in Children With Congenital and Acquired Heart Disease. Elbers, J., Lee, E., Yarlagadda, V. V., Lo, C., Hanisch, D., Lin, A., Almond, C. S., Shin, A. Y. LIPPINCOTT WILLIAMS & WILKINS. 2016
  • Updated analysis: central venous access device infection rates in an expanded cohort of paediatric patients with severe haemophilia receiving prophylactic recombinant tissue plasminogen activator. Haemophilia McCarthy, C. E., O'Brien, M., Andrews, J., Zoland, J. M., Macasiray, E., Wong, W., Lo, C., Glader, B., TAMARESIS, J., Jeng, M. 2016; 22 (1): 81-86

    Abstract

    Central venous access devices (CVADs) are used in the care of paediatric haemophilic patients with difficult peripheral access, but their use is limited by complications such as infection. We previously published our experience with monthly recombinant tissue plasminogen activator (r-tPA) administration to CVADs of haemophilic patients as an intervention for infection prophylaxis, which suggested a 10-fold decrease in infection rate compared to published rates without r-tPA.This study was conducted to assess the CVAD infection rate in an expanded haemophilia cohort receiving r-tPA over an extended period.A retrospective review was performed on patients with haemophilia who received monthly r-tPA to CVADs, with data collected from January 1, 2008 to December 31, 2012. The data were merged with the previously reported data set (collected from June 1, 1998 to December 31, 2007).Over the entire observation period, there were 46 350 CVAD days among 32 patients [26 severe factor VIII (FVIII) deficiency, six severe FIX deficiency]. Eight patients received immune tolerance therapy for inhibitors and 24 patients received prophylactic factor administration. No patients were HIV positive. Three infections were observed, with an overall infection rate of 0.06 infections per 1000 CVAD days.A low CVAD infection rate, similar to that observed in our previous study (0.04 per 1000 CVAD days), was observed in this expanded haemophilia cohort treated with prophylactic r-tPA, supporting the use of monthly r-tPA as CVAD infection prophylaxis in haemophilia patients.

    View details for DOI 10.1111/hae.12772

    View details for PubMedID 26248602

  • Neonatal Thrombocytopenia Neonatology: Clinical Practice and Procedures Lo, C., Glader, B., Wong, W. 2015
  • Female Gender and Hispanic Ethnicity are Associated with Increased Risk of Subacute Methotrexate Encephalopathy Toxicology: Open Access Lo, C. Y., Campen, C., Luna-Fineman, S., Lacayo, N. J., Fisher, P. G., Dahl, G. V. 2015

    View details for DOI 10.4172/TYOA.1000105

  • Polycythemia Neonatology: Clinical Practice and Procedures Lo, C., Wong, W. 2015
  • Bone marrow failure Rodack’s Hematology: Clinical Principles and Applications Lo, C., Glader, B., Sakamoto, K. 2015
  • Immune Thrombocytopenia in Children Less Than 1 Year of Age: A Single-institution 10-year Experience. Journal of pediatric hematology/oncology Lo, C., Wong, W., Glader, B., Jeng, M. 2013; 35 (5): 406-408

    Abstract

    Immune thrombocytopenia (ITP) in children less than one year of age is less well characterized compared to ITP in toddlers and school-age children. We performed a 10-year retrospective review of ITP patients in this age-cohort at our institution. Diagnosis and classification were made according to the 2009 International Working Group criteria. Fourteen infants were identified. Their bleeding scores were Grades 1 to 2 (79%), Grade 3 (22%), Grades 4 to 5 (0%). Eight patients received treatment with a 75% response rate. Three patients (21%) developed chronic ITP. These observations suggest that ITP in very young patients is similar to typical childhood ITP.

    View details for DOI 10.1097/MPH.0b013e3182580ab4

    View details for PubMedID 22767132

  • The Role of Oxidative Stress in Pediatric Immune Thrombocytopenia 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) Lo, C., Zhang, B., Cusmano-Ozog, K., Wong, W., Jeng, M., Cowan, T., Zehnder, J. L. AMER SOC HEMATOLOGY. 2012
  • The Role of Oxidative Stress in Pediatric Immune Thrombocytopenia Lo, C., Zhang, B., Cusmano-Ozog, K., Wong, W., Jeng, M., Cowan, T., Zehnder, J. L. AMER SOC HEMATOLOGY. 2012
  • CLINICAL PRESENTATION AND MANAGEMENT OF SUBACUTE METHOTREXATE-INDUCED ENCEPHALOPATHY IN PATIENTS WITH PEDIATRIC MALIGNANCIES Lo, C., Campen, C., Lacayo, N., Dahl, G. WILEY-BLACKWELL. 2012: 1050–51
  • Chronic Oxidative Stress and Endothelial Dysfunction in Sickle Cell Disease Sickle Cell Disease: A New Vision for an Old Problem Lo, C., Morris, C. 2012
  • IMMUNE-MEDIATED THROMBOCYTOPENIA IN CHILDREN LESS THAN 1 YEAR OF AGE: A SINGLE-INSTITUTION 10-YEAR EXPERIENCE Lo, C., Newman, A., Wong, W., Glader, B., Jeng, M. WILEY-BLACKWELL. 2011: 915–15
  • The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP BLOOD Zhang, B., Lo, C., Shen, L., Sood, R., Jones, C., Cusmano-Ozog, K., Park-Snyder, S., Wong, W., Jeng, M., Cowan, T., Engleman, E. G., Zehnder, J. L. 2011; 117 (17): 4569-4579

    Abstract

    Pediatric immune thrombocytopenia (ITP) is usually self-limited. However, approximately 20% of children develop chronic ITP, which can be associated with significant morbidity because of long-term immunosuppression and splenectomy in refractory cases. To explore the molecular mechanism of chronic ITP compared with acute ITP, we studied 63 pediatric patients with ITP. Gene expression analysis of whole blood revealed distinct signatures for acute and chronic ITP. Oxidative stress-related pathways were among the most significant chronic ITP-associated pathways. Overexpression of VNN1, an oxidative stress sensor in epithelial cells, was most strongly associated with progression to chronic ITP. Studies of normal persons demonstrated VNN1 expression in a variety of blood cells. Exposure of blood mononuclear cells to oxidative stress inducers elicited dramatic up-regulation of VNN1 and down-regulation of PPARγ, indicating a role for VNN1 as a peripheral blood oxidative stress sensor. Assessment of redox state by tandem mass spectrometry demonstrated statistically significant lower glutathione ratios in patients with ITP versus healthy controls; lower glutathione ratios were also seen in untreated patients with ITP compared with recently treated patients. Our work demonstrates distinct patterns of gene expression in acute and chronic ITP and implicates oxidative stress pathways in the pathogenesis of chronic pediatric ITP.

    View details for DOI 10.1182/blood-2010-09-304931

    View details for PubMedID 21325602

  • Development of Antibodies to Human Thrombin and Factor V in a Patient Exposed to Topical Bovine Thrombin PEDIATRIC BLOOD & CANCER Lo, C. Y., Jones, C., Glader, B., Zehnder, J. L. 2010; 55 (6): 1195-1197

    Abstract

    Bovine topical thrombin is commonly used for local hemostasis in pediatric surgery. Acquired inhibitors to coagulation factors, particularly to factor V and bovine thrombin, have been infrequently reported in the pediatric population. We report a 3-year-old male who developed a coagulopathy and clinical bleeding after cardiothoracic surgery, during which bovine topical thrombin was used for local hemostasis. Laboratory tests revealed elevated prothrombin, partial thromboplastin, and thrombin times, and a low factor V activity level. He was found to have both human-thrombin and factor V inhibitors, among the first reported cases of these combined inhibitors secondary to bovine topical thrombin. He was treated with intravenous immunoglobulin and steroids with a rapid and durable response.

    View details for DOI 10.1002/pbc.22699

    View details for PubMedID 20979176