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Chris Severyn, MD, PhD, is a physician-scientist with a special interest in hematopoiesis, bone marrow failure, and infectious complications in hematology-oncology and hematopoietic cell transplant (HCT) patients. He received his MD and PhD in Biochemistry/Molecular Biology from Oregon Health & Science University (OHSU), where he studied the transcriptional regulation of a gene involved in iron metabolism. He carried out his pediatrics residency at Duke University and then joined as clinical faculty in the bone marrow transplant unit at Duke Children’s Hospital. He subsequently completed his fellowship in pediatric Hematology/Oncology at Lucile Packard Children’s Hospital at Stanford University. He is currently an Instructor of Pediatrics at Stanford University with the Division of Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine. His research focuses on (1) origins of microbial infections from the gut microbiota, (2) microbial factors that may affect hematopoietic reconstitution at the immune-microbial interface, and (3) understanding clinical interventions that alter the microbiome to improve outcomes.
My research focuses on the (1) origins of microbial infections from the gut microbiota, (2) microbial factors that may affect hematopoietic reconstitution at the immune-microbial interface, and (3) understanding clinical interventions that alter the microbiome to improve outcomes.
Gut Decontamination In Pediatric Allogeneic Hematopoietic
This research study is for participants who are undergoing allogeneic hematopoietic stem cell
transplantation (HSCT) and are at risk for developing acute graft-versus-host disease (GVHD).
GVHD is a complication of HSCT in which immune cells from the donor cause inflammation and
injury to tissues and organs of the HSCT recipient. Vancomycin-polymyxin B (commonly called
"vancopoly") is an oral antibiotic that is given to people undergoing allogeneic HSCT as a
preventive measure for acute GVHD. This research study is studying the effects of vancopoly
on the microorganisms living in the intestine during and after stem cell transplantation.
Stanford is currently not accepting patients for this trial.
For more information, please contact SPECTRUM, .
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