Tissue engineering in flexor tendon surgery: current state and future advances
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
2014; 39 (1): 71-78
Tissue engineering of flexor tendons addresses a challenge often faced by hand surgeons: the restoration of function and improvement of healing with a limited supply of donor tendons. Creating an engineered tendon construct is dependent upon understanding the normal healing mechanisms of the tendon and tendon sheath. The production of a tendon construct includes: creating a three-dimensional scaffold; seeding cells within the scaffold; encouraging cellular growth within the scaffold while maintaining a gliding surface; and finally ensuring mechanical strength. An effective construct incorporates these factors in its design, with the ultimate goal of creating tendon substitutes that are readily available to the reconstructive hand surgeon.
View details for DOI 10.1177/1753193413512432
View details for Web of Science ID 000328829100009
View details for PubMedID 24262584
"Click" and Olefin Metathesis Chemistry in Water at Room Temperature Enabled by Biodegradable Micelles.
Journal of chemical education
2013; 90 (11)
The two laboratory reactions focus on teaching several concepts associated with green chemistry. Each uses a commercial, nontoxic, and biodegradable surfactant, TPGS-750-M, to promote organic reactions within the lipophilic cores of nanoscale micelles in water. These experiments are based on work by K. Barry Sharpless (an azide-alkyne "click" reaction) and Robert Grubbs (an olefin cross-metathesis reaction); both are suitable for an undergraduate organic laboratory. The copper-catalyzed azide-alkyne [3+2] cycloaddition of benzyl azide and 4-tolylacetylene is very rapid: the triazole product is readily isolated by filtration and is characterized by thin-layer chromatography and melting point analysis. The ruthenium-catalyzed olefin cross-metathesis reaction of benzyl acrylate with 1-hexene is readily monitored by thin-layer chromatography and gas chromatography. The metathesis experiment comparatively evaluates the efficacy of a TPGS-750-M/water medium relative to a traditional reaction performed in dichloromethane (a common solvent used for olefin metathesis).
View details for DOI 10.1021/ed300893u
View details for PubMedID 24324282
CuH-Catalyzed Enantioselective 1,2-Reductions of alpha,beta-Unsaturated Ketones
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2010; 132 (23): 7852-?
The first study on a general technology for arriving at valued nonracemic allylic alcohols using asymmetric ligand-accelerated catalysis by copper hydride is described.
View details for DOI 10.1021/ja102689e
View details for Web of Science ID 000278717700015
View details for PubMedID 20481528
COMPARATIVE EFFECTIVENESS FOR BARIATRIC SURGERY: CARDIAC RISK FACTOR REDUCTION
ELSEVIER SCIENCE INC. 2013: E1425-E1425
View details for Web of Science ID 000316555201530