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Dr Cartwright is a Professor of Medicine and Gastroenterology with tenure at Stanford University. She trained at the University of California San Diego and the Salk Institute for Biological Studies before joining the Stanford Faculty in 1989. Her research in cancer biology focuses on understanding how normal intestinal cells regulate their growth and how loss of that regulation results in malignant transformation. She is an author on numerous scientific publications. Her research has been supported by grants from the National Institutes of Health (for 30 years), the American Cancer Society, the Broad Medical Research Foundation and the Crohn’s and Colitis Foundation of America. She has served on NIH and American Cancer Society Study Sections and on the Editorial Board of the Gastrointestinal and Liver Physiology section of the American Journal of Physiology. In 1995 she was inducted into the American Society for Clinical Investigation. In 2008 she received an Outstanding Woman in Science Award from the American Gastroenterological Association (AGA) for her contributions to GI research. She has been an invited speaker, organizer and chairperson for numerous national AGA symposia on the molecular biology of gastrointestinal cancers. Dr Cartwright’s clinical interests focus on caring for those with inflammatory bowel diseases. She has cared for nearly 5,000 IBD patients over the past 3 decades. She served as Director of the Program for Inflammatory Bowel Diseases at Stanford University (1989-2007). She also served on the Editorial Board of the Inflammatory Bowel Diseases Journal and on the National Scientific Advisory Committee (Clinical Affairs/Professional Education) of the Crohn’s and Colitis Foundation of America. In 2000 she received the Premier Physician Award from the Crohn’s & Colitis Foundation of America Greater Bay Area Chapter. She has been an invited speaker, organizer and chairperson for numerous IBD symposia in northern California. In 2020 she was nominated for the Master Clinician Award in the Department of Medicine, and in 2021 she was nominated for the Physician of the Year Award, Stanford University School of Medicine.
Crohn's and Colitis Foundation of America
people with Inflammatory Bowel Diseases
Clinical Care and Education
Research in my laboratory focuses on molecular mechanisms of intestinal cell growth control. A primary focus is on function and regulation of the Src family of tyrosine kinases in normal cells, and their deregulation in cancer cells. Molecular, cellular and physiologic approaches are used to explore basic questions about growth regulation. Areas of active investigation include studies of Src function in cell cycle progression, proliferation, differentiation, adhesion, survival and malignant transformation; discovery of endogenous inhibitors of Src kinases; analysis of inhibitor function in cell growth control and apoptosis; and exploration of new drug therapy for colon cancer. Our recent discovery of a Src inhibitor, RACK1, which works both to inhibit growth (by suppressing Src activity at G1 and mitotic checkpoints) and to induce death of colon cells, could be exploited for development of new and more powerful and selective strategies for treatment of human colon cancer.