Institute Affiliations

  • Member, Maternal & Child Health Research Institute (MCHRI)

Professional Education

  • Doctor of Philosophy, Cornell University (2016)
  • Bachelor of Arts, Dartmouth College (2008)

Stanford Advisors


All Publications

  • The 5-HTTLPR Long, not Short, Allele Predicts Two-year Longitudinal Increases in Cortisol and Declines in Verbal Memory in Older Adults. International journal of geriatric psychiatry Hirst, R. B., Jordan, J. T., Miryam Schussler-Fiorenza Rose, S., Schneider, L., Kawai, M., Gould, C., Anker, L., Chick, C. F., Beaudreau, S., Hallmayer, J., O'Hara, R. 2020


    OBJECTIVES: The short form or s-allele variant of the serotonin transporter polymorphism (5-HTTLPR), as compared with the long form or l-allele variant, has been associated with the presence of cognitive dysfunction, and particularly memory impairment in older adults. This body of cross-sectional work has culminated in the hypothesis that presence of the s-allele predicts greater memory decline in older adults (1). Yet, to date, there are no longitudinal studies which have investigated this issue.METHODS/DESIGN: Here we examine 109 community-dwelling older adults (mean and SD of age=70.7±8.7years) who underwent blood draw for genotyping, cognitive, and psychological testing at baseline, 12-month, and 24-month follow-up.RESULTS: Multilevel modeling found that s-allele carriers (ss or ls) performed worse than ll homozygotes at baseline on delayed verbal recall. Yet, s-allele carriers' memory performance was stable over the two-year follow-up period, while l-allele homozygotes experienced significant memory decline. l-allele homozygote status was associated with both increased cortisol and decreased memory over time, resulting in attenuated verbal memory performance differences compared to s-allele carriers with age.CONCLUSIONS: Overall, our findings do not support the hypothesis that presence of the 5-HTTLPR s-allele is a marker for memory decline in older adults. This article is protected by copyright. All rights reserved.

    View details for DOI 10.1002/gps.5319

    View details for PubMedID 32400901

  • Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders. The American journal of psychiatry McTeague, L. M., Rosenberg, B. M., Lopez, J. W., Carreon, D. M., Huemer, J., Jiang, Y., Chick, C. F., Eickhoff, S. B., Etkin, A. 2020: appiajp201918111271


    OBJECTIVE: Disrupted emotional processing is a common feature of many psychiatric disorders. The authors investigated functional disruptions in neural circuitry underlying emotional processing across a range of tasks and across psychiatric disorders through a transdiagnostic quantitative meta-analysis of published neuroimaging data.METHODS: A PubMed search was conducted for whole-brain functional neuroimaging findings published through May 2018 that compared activation during emotional processing tasks in patients with psychiatric disorders (including schizophrenia, bipolar or unipolar depression, anxiety, and substance use) to matched healthy control participants. Activation likelihood estimation (ALE) meta-analyses were conducted on peak voxel coordinates to identify spatial convergence.RESULTS: The 298 experiments submitted to meta-analysis included 5,427 patients and 5,491 control participants. ALE across diagnoses and patterns of patient hyper- and hyporeactivity demonstrated abnormal activation in the amygdala, the hippocampal/parahippocampal gyri, the dorsomedial/pulvinar nuclei of the thalamus, and the fusiform gyri, as well as the medial and lateral dorsal and ventral prefrontal regions. ALE across disorders but considering directionality demonstrated patient hyperactivation in the amygdala and the hippocampal/parahippocampal gyri. Hypoactivation was found in the medial and lateral prefrontal regions, most pronounced during processing of unpleasant stimuli. More refined disorder-specific analyses suggested that these overall patterns were shared to varying degrees, with notable differences in patterns of hyper- and hypoactivation.CONCLUSIONS: These findings demonstrate a pattern of neurocircuit disruption across major psychiatric disorders in regions and networks key to adaptive emotional reactivity and regulation. More specifically, disruption corresponded prominently to the "salience" network, the ventral striatal/ventromedial prefrontal "reward" network, and the lateral orbitofrontal "nonreward" network. Consistent with the Research Domain Criteria initiative, these findings suggest that psychiatric illness may be productively formulated as dysfunction in transdiagnostic neurobehavioral phenotypes such as neurocircuit activation.

    View details for DOI 10.1176/appi.ajp.2019.18111271

    View details for PubMedID 31964160

  • Transcranial magnetic stimulation demonstrates a role for the ventrolateral prefrontal cortex in emotion perception. Psychiatry research Chick, C. F., Rolle, C., Trivedi, H. M., Monuszko, K., Etkin, A. 2019: 112515


    The lateral prefrontal cortex, a region with both structural and functional connectivity to the amygdala, has been consistently implicated in the downregulation of subcortical-generated emotional responses. Although previous work has demonstrated that the ventral lateral prefrontal cortex (vlPFC) is important to emotion processing, no study has interrupted vlPFC function in order to test is role in emotion perception. In the current study, we acutely disrupted vlPFC function in twenty healthy adult participants by administering sham stimulation and transcranial magnetic stimulation (TMS), in randomized order, during performance of an emotional perception task. During sham stimulation, participants demonstrated increased perceptual sensitivity for happy faces compared to angry faces. Disruption of the vlPFC eliminated this difference: in this condition, perceptual sensitivity did not differ between happy and angry faces. Reaction times and response bias did not differ between emotions or TMS conditions. This pattern of perceptual bias is consistent with effects observed in a wide range of affective disorders, in which vlPFC dysfunction has also been reported. This study provides insight into a possible mechanism through which the vlPFC may contribute to emotion perception.

    View details for DOI 10.1016/j.psychres.2019.112515

    View details for PubMedID 31831202

  • Cooperative versus competitive influences of emotion and cognition on decision making: A primer for psychiatry research. Psychiatry research Chick, C. F. 2019; 273: 493–500


    Clinical research across the developmental spectrum increasingly reveals the nuanced ways in which emotion and cognition can work to either support or derail rational (i.e., healthy or goal-consistent) decision making. However, psychological theories offer discrepant views on how these processes interact, and on whether emotion is helpful or harmful to rational decision making. In order to translate theoretical predictions from basic psychology to clinical research, an understanding of theoretical perspectives on emotion and cognition, as informed by experimental psychology, is needed. Here, I review the ways in which dual-process theories have incorporated emotion into the process of decision making, discussing how they account for both positive and negative influences. I first describe seven theoretical perspectives that make explicit assumptions and predictions about the interaction between emotion and cognition: affect as information, the affect heuristic, risk as feelings, hot versus cool cognition, the somatic parker hypothesis, prospect theory, and fuzzy-trace theory. I then discuss the conditions under which each theoretical perspective conceptualizes emotion as beneficial or harmful to decision making, providing examples from research on psychiatric disorders.

    View details for PubMedID 30708200

  • My Body, Your Emotions: Viscerosomatic Modulation of Facial Expression Discrimination. Biological psychology Chick, C. F., Rounds, J. D., Hill, A. B., Anderson, A. K. 2019: 107779


    Interoception reflects the ability to observe one's innermost bodily states. Here, we assessed whether interoceptive accuracy (IA) is related to the empathic ability to discriminate others' emotions. Participants (N = 111) completed a heartbeat tracking task, as well as an emotional go/no-go task with fearful and disgusted faces. Empathic facial mimicry during the go/no-go task was measured using electromyography (EMG) of the Corrugator Supercilii muscle. Higher IA was associated with higher perceptual sensitivity for emotional faces but was unrelated to response bias. Individuals higher in IA had stronger coupling between facial EMG and task performance. IA and facial EMG were associated with Go but not with NoGo trials, consistent with a specific modulation of perceptual sensitivity. These results suggest that tuning into one's own viscerosomatic signals relates to empathic mimicry and perception of others' emotional states.

    View details for DOI 10.1016/j.biopsycho.2019.107779

    View details for PubMedID 31644926

  • Factors Associated with Supportive Care Service Use Among California Alzheimer's Disease Patients and Their Caregivers. Journal of Alzheimer's disease : JAD Newkirk, L. A., Dao, V. L., Jordan, J. T., Alving, L. I., Davies, H. D., Hewett, L., Beaudreau, S. A., Schneider, L. D., Gould, C. E., Chick, C. F., Hirst, R. B., Rose, S. M., Anker, L. A., Tinklenberg, J. R., O'Hara, R. 2019


    Existing literature on factors associated with supportive care service (SCS) use is limited. A better understanding of these factors could help tailor SCS to the needs of frequent users, as well as facilitate targeted outreach to populations that underutilize available services.To investigate the prevalence of SCS use and to identify factors associated with, and barriers to, service use.California Alzheimer's Disease Center patients with AD (n = 220) participated in the study from 2006-2009. Patients and their caregivers completed assessments to determine SCS use. Cognitive, functional, and behavioral status of the patients were also assessed. A two-part hurdle analysis identified 1) factors associated with any service use and 2) service use frequency among users.Forty percent of participants reported using at least one SCS. Patients with more impaired cognition and activities of daily living and more of the following: total number of medications, comorbid medical conditions, and years of education were more likely to use any SCS (p < 0.05). Factors associated with more frequent SCS use included younger age, more years of education, older age of AD onset, female gender, and having a spouse or relative for a caregiver (p < 0.05). Caregivers frequently indicated insufficient time as a reason for not receiving enough services.Factors associated with any SCS use mostly differed from those associated with SCS frequency, suggesting different characteristics between those who initiate versus those who continue SCS use. Our findings highlight the importance of targeted education on services and identifying barriers to long-term SCS use.

    View details for DOI 10.3233/JAD-190438

    View details for PubMedID 31743997

  • Failure to Downregulate Amygdala Activation during Regulation of Emotional Conflict in Post Traumatic Stress Disorder: Results from a Large Veteran Sample Chick, C., de los Angeles, C., Patenaude, B., Longwell, P., Shpigel, E., Gonzalez, B., Durkin, K., Chen, J., Abu Amara, D., Hart, R., Mann, S., Maron-Katz, A., Marmar, C., Etkin, A. ELSEVIER SCIENCE INC. 2017: S193
  • Framing Effects Are Robust to Linguistic Disambiguation: A Critical Test of Contemporary Theory JOURNAL OF EXPERIMENTAL PSYCHOLOGY-LEARNING MEMORY AND COGNITION Chick, C. F., Reyna, V. F., Corbin, J. C. 2016; 42 (2): 238–56


    Theoretical accounts of risky choice framing effects assume that decision makers interpret framing options as extensionally equivalent, such that if 600 lives are at stake, saving 200 implies that 400 die. However, many scholars have argued that framing effects are caused, instead, by filling in pragmatically implied information. This linguistic ambiguity hypothesis is grounded in neo-Gricean pragmatics, information leakage, and schema theory. In 2 experiments, we conducted critical tests of the linguistic ambiguity hypothesis and its relation to framing. We controlled for this crucial implied information by disambiguating it using instructions and detailed examples, followed by multiple quizzes. After disambiguating missing information, we presented standard framing problems plus truncated versions, varying types of missing information. Truncations were also critical tests of prospect theory and fuzzy trace theory. Participants were not only college students, but also middle-age adults (who showed similar results). Contrary to the ambiguity hypothesis, participants who interpreted missing information as complementary to stated information nonetheless showed robust framing effects. Although adding words like "at least" can change interpretations of framing information, this form of linguistic ambiguity is not necessary to observe risky choice framing effects.

    View details for DOI 10.1037/xlm0000158

    View details for Web of Science ID 000369440000005

    View details for PubMedID 26348200

    View details for PubMedCentralID PMC4738018

  • Reward Processing in the Adolescent Brain: Individual Differences and Relation to Risk Taking JOURNAL OF NEUROSCIENCE Chick, C. F. 2015; 35 (40): 13539–41
  • An Overview of Judgment and Decision Making Research Through the Lens of Fuzzy Trace Theory. Xin li ke xue jin zhan Setton, R., Wilhelms, E., Weldon, B., Chick, C., Reyna, V. 2014; 22 (12): 1837–54


    We present the basic tenets of fuzzy trace theory, a comprehensive theory of memory, judgment, and decision making that is grounded in research on how information is stored as knowledge, mentally represented, retrieved from storage, and processed. In doing so, we highlight how it is distinguished from traditional models of decision making in that gist reasoning plays a central role. The theory also distinguishes advanced intuition from primitive impulsivity. It predicts that different sorts of errors occur with respect to each component of judgment and decision making: background knowledge, representation, retrieval, and processing. Classic errors in the judgment and decision making literature, such as risky-choice framing and the conjunction fallacy, are accounted for by fuzzy trace theory and new results generated by the theory contradict traditional approaches. We also describe how developmental changes in brain and behavior offer crucial insight into adult cognitive processing. Research investigating brain and behavior in developing and special populations supports fuzzy trace theory's predictions about reliance on gist processing.

    View details for DOI 10.3724/SP.J.1042.2014.01837

    View details for PubMedID 28725239

  • Basic Mechanisms of Numerical Processing: Cross-Modal Number Comparisons and Symbolic Versus Nonsymbolic Numerosity in the Intraparietal Sulcus JOURNAL OF NEUROSCIENCE Chick, C. F. 2014; 34 (5): 1567–69
  • Developmental Reversals in Risky Decision Making: Intelligence Agents Show Larger Decision Biases Than College Students PSYCHOLOGICAL SCIENCE Reyna, V. F., Chick, C. F., Corbin, J. C., Hsia, A. N. 2014; 25 (1): 76–84


    Intelligence agents make risky decisions routinely, with serious consequences for national security. Although common sense and most theories imply that experienced intelligence professionals should be less prone to irrational inconsistencies than college students, we show the opposite. Moreover, the growth of experience-based intuition predicts this developmental reversal. We presented intelligence agents, college students, and postcollege adults with 30 risky-choice problems in gain and loss frames and then compared the three groups' decisions. The agents not only exhibited larger framing biases than the students, but also were more confident in their decisions. The postcollege adults (who were selected to be similar to the students) occupied an interesting middle ground, being generally as biased as the students (sometimes more biased) but less biased than the agents. An experimental manipulation testing an explanation for these effects, derived from fuzzy-trace theory, made the students look as biased as the agents. These results show that, although framing biases are irrational (because equivalent outcomes are treated differently), they are the ironical output of cognitively advanced mechanisms of meaning making.

    View details for DOI 10.1177/0956797613497022

    View details for Web of Science ID 000329486300008

    View details for PubMedID 24171931

    View details for PubMedCentralID PMC4076289

  • Correspondence Are Cognitive Functions Localizable? JOURNAL OF ECONOMIC PERSPECTIVES Camerer, C., Smith, A., Kuhnen, C. M., Wargo, D. T., Samanez-Larkin, G., Montague, R., Levy, D. J., Smith, D., Meshi, D., Kenning, P. H., Clithero, J., Weber, B., Hare, T., Huettel, S., Josephson, C., d'Acremont, M., Knoch, D., Krajbich, I., De Martino, B., Mohr, P. C., Barton, J., Halko, M., Chick, C. F., Gianotti, L., Heekeren, H. R. 2013; 27 (2): 247–50

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