Che-Hong Chen

Senior Research Scientist - Basic Life, Chemical and Systems Biology Operations

Bio

Dr. Che-Hong Chen is a molecular biologist and geneticist at the Department of Chemical and Systems Biology, Stanford University, School of Medicine. Dr. Chen’s research focuses on aldehyde toxicity and the function of the ALDH multi-gene family in humans. His research is highlighted by the discovery of a class of novel enzyme modulators of aldehyde dehydrogenase. Some of these small molecule modulators are potent enzyme activators for the variant East Asian-specific dysfunctional ALDH2 which causes the alcohol flushing syndrome and affects approximately 560 million people, or 8% of the world population. Using an ALDH2-deficient mouse model in combination with clinical research, Dr. Chen is currently studying the molecular mechanisms underlying the pathology of diseases associated with aldehyde toxicity and genetic susceptibility of ALDH variation in human populations. Together with Prof. Daria Mochly-Rosen, Che-Hong established the Stanford-Taiwan ALDH2 Deficiency Research (STAR) consortium (now International ALDH2 STAR Research Consortium) in 2015. In 2017, Dr. Chen founded a non-profit organization of Taiwan Alcohol Intolerance Education Society (TAIES) in Taiwan. Dr. Chen is now actively promoting public health education, cancer prevention and the awareness of health risks associated with harmful alcohol use and alcohol flushing caused by ALDH2 deficiency in Taiwan and East Asia.

Current Role at Stanford

Senior Research Scientist<br/>CEO, International ALDH2 STAR Research Consortium<br/>Director of China, Singapore, and Taiwan Outreach, Center for Asian Health Research and Education Center

Education & Certifications

Postodoctoral Fellow, Cornell University, Plant Biology (1990)
Ph.D., University of California, Berkeley, Genetics (1986)
B.S., National Taiwan University (1979)

All Publications

Profiles With Related Publications

close
Euan A. Ashley

Associate Dean, School of Medicine, Roger and Joelle Burnell Professor of Genomics and Precision Health, Professor of Medicine (Cardiovascular Medicine), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
Clinical Focus
Cardiology, Inherited cardiovascular disease, Hypertrophic Cardiomyopathy, Cardiomyopathy, Dilated, Sports Cardiology, Heart Failure, Arrhythmogenic Right Ventricular Dysplasia, Left ventricular non-compaction cardiomyopathy, Genomic medicine, Undiagnosed disease
Research Interests
The Ashley lab is focused on precision medicine. We develop methods for the interpretation of whole genome sequencing data to improve the diagnosis of genetic disease and to personalize the practice of medicine. At the wet bench, we take advantage of cell systems, transgenic models and microsurgical models of disease to prove causality in biological pathways and find targets for therapeutic development.

581 Total Publications
close
Daniel Bernstein

Alfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics
Clinical Focus
Pediatric Cardiology, Pediatric Heart Transplantation, Pediatric Heart Failure
Research Interests
1. Using iPSC-derived cardiomyocytes to understand hypertrophic cardiomyopathy and heart failure associated with congenital heart disease.
2. Role of alterations in mitochondrial dycamics and function in normal physiology and disease.
3. Differences between R and L ventricular responses to stress,
4. Immune biomarkers of risk after pediatric VAD implantation.
5. Biomarkers for post-transplant lymphoproliferative disorder.

365 Total Publications
close
Chris Garcia

Younger Family Professor and Professor of Structural Biology
Research Interests
Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.

348 Total Publications
close
Kevin Grimes

Professor (Teaching) of Chemical and Systems Biology
Clinical Focus
Internal Medicine

23 Total Publications
close
Gentaro Ikeda

Instructor, Medicine - Cardiovascular Medicine

15 Total Publications
close
Michael J. Kaplan, MD

Professor of Otolaryngology - Head & Neck Surgery at the Stanford University Medical Center, Emeritus
Research Interests
1) New therapeutic approaches for head and neck cancer, including immune stimulation possibilities (IRX-2 protocol), integration of biological modifiers, and, eventually, genetic approaches.
2) Head and neck cancer stem cells: identification, characterization, control--in conjunction with the Irv Weissman and Michael Clarke labs in the Stem Cell Institute
3) Development of innovative surgical methods at the anterior cranial base

69 Total Publications
close
Ioannis Karakikes

Associate Professor (Research) of Cardiothoracic Surgery
Research Interests
The Karakikes Lab aims to uncover fundamental new insights into the molecular mechanisms and functional consequences of pathogenic mutations associated with familial cardiovascular diseases.

78 Total Publications
close
Christina Kong

Professor of Pathology
Clinical Focus
Cytopathology, Gynecologic Pathology, Head & Neck Pathology, Anatomic and Clinical Pathology
Research Interests
Improving the accuracy of cytologic diagnosis through the use of ancillary techniques on specimens obtained by fine needle aspiration biopsy.

Identifying potential indicators of prognosis in head and neck squamous cell carcinomas.

Evaluating the utility of immunohistochemical stains in refining the diagnosis of squamous dysplasia of the cervix, vulva, and head and neck.

167 Total Publications
close
Jinliang Li

Sr Res Scientist-Basic Life, Ophthalmology Research/Clinical Trials

37 Total Publications
close
Daria Mochly-Rosen

George D. Smith Professor of Translational Medicine
Research Interests
Two areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. Focus: protein kinase C in heart and large GTPases regulating mitochondrial dynamics in neurodegdenration. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucose-6-phoshate dehydrogenase, in normal cells and in models of human diseases.

409 Total Publications
close
Jonathan Mulholland

Director, CSIF, School of Medicine - CMGM

27 Total Publications
close
Garry Nolan

Rachford and Carlota Harris Professor
Research Interests
Dr. Nolan's group uses high throughput single cell analysis technology cellular biochemistry to study autoimmunity, cancer, virology (influenza & Ebola), as well as understanding normal immune system function. Using advanced flow cytometric techniques such as Mass Cytometry, MIBI (ion beam imaging), CODEX and computational biology approaches, we focus on understanding disease processes at the single cell level. We have a strong interest in cancer immunotherapy and pathogen-host interactions.

466 Total Publications