Bio

Clinical Focus


  • Thyroid pathology
  • Salivary gland tumors
  • Sinusitis
  • Ear Diseases
  • Otolaryngology

Academic Appointments


Professional Education


  • Board Certification: Otolaryngology, American Board of Otolaryngology (2013)
  • Residency:Stanford University School of Medicine (2012) CA
  • Internship:Stanford University School of Medicine (2007) CA
  • Medical Education, Cambridge University, England (2001)
  • Medical Education:University College of London (2004) England

Research & Scholarship

Current Research and Scholarly Interests


Surgical Simulation
Biorobotics

Publications

Journal Articles


  • Evaluating the utility of non-echo-planar diffusion-weighted imaging in the preoperative evaluation of cholesteatoma: A meta-analysis. Laryngoscope Li, P. M., Linos, E., Gurgel, R. K., Fischbein, N. J., Blevins, N. H. 2013; 123 (5): 1247-1250

    Abstract

    To describe the accuracy of non-echo-planar diffusion-weighted magnetic resonance imaging (DW MRI) in identifying middle ear cholesteatoma.A meta-analysis of the published literature.A systematic review of the literature was performed to identify studies in which patients suspected of having middle ear cholesteatoma underwent DW MRI scans prior to surgery. A meta-analysis of the included studies was performed.Ten published articles (342 patients) met inclusion criteria. Cholesteatoma was confirmed in 234 patients, of which 204 were detected by DW MRI (true positives) and 30 were not (false negatives). One hundred eight patients did not have cholesteatoma on surgical examination, and of these 100 were correctly identified by MRI (true negatives) whereas eight were not (false positives). The overall sensitivity of DW MRI in detecting cholesteatoma was 0.94 (confidence interval, 0.80-0.98) and specificity 0.94 (confidence interval, 0.85-0.98). DW MRI sequences could not reliably detect cholesteatomas under 3 mm in size.Non-echo-planar DW MRI is highly sensitive and specific in identifying middle ear cholesteatoma. DW MRI may help to stratify patients into groups of who would benefit from early second-look surgery and those who could be closely observed.2a.

    View details for DOI 10.1002/lary.23759

    View details for PubMedID 23023958

  • Superior semicircular canal dehiscence diagnosed after failed stapedotomy for conductive hearing loss AMERICAN JOURNAL OF OTOLARYNGOLOGY Li, P. M., Bergeron, C., Monfared, A., Agrawal, S., Blevins, N. H. 2011; 32 (5): 441-444

    View details for DOI 10.1016/j.amjoto.2010.07.016

    View details for Web of Science ID 000294704200017

    View details for PubMedID 20888070

  • A virtual surgical environment for rehearsal of tympanomastoidectomy. Studies in health technology and informatics Chan, S., Li, P., Lee, D. H., Salisbury, J. K., Blevins, N. H. 2011; 163: 112-118

    Abstract

    This article presents a virtual surgical environment whose purpose is to assist the surgeon in preparation for individual cases. The system constructs interactive anatomical models from patient-specific, multi-modal preoperative image data, and incorporates new methods for visually and haptically rendering the volumetric data. Evaluation of the system's ability to replicate temporal bone dissections for tympanomastoidectomy, using intraoperative video of the same patients as guides, showed strong correlations between virtual and intraoperative anatomy. The result is a portable and cost-effective tool that may prove highly beneficial for the purposes of surgical planning and rehearsal.

    View details for PubMedID 21335772

Conference Proceedings


  • Controlled steroid delivery via bioabsorbable stent: Safety and performance in a rabbit model Li, P. F., Downie, D., Hwang, P. H. OCEAN SIDE PUBLICATIONS INC. 2009: 591-596

    Abstract

    Middle turbinate lateralization, adhesions, and inflammation are causes of suboptimal sinus patency following surgery. A bioabsorbable drug-eluting stent has been developed to maintain sinus patency while providing controlled steroid delivery to the sinus mucosa. The aim of this study was to characterize the in vivo drug delivery efficacy and tolerance of this stent in a rabbit model.Bioabsorbable stents coated with mometasone furoate were placed bilaterally in the maxillary sinuses of 31 rabbits via dorsal maxillary sinusotomy. Animals were sacrificed between 5 days and 18 weeks postoperatively. Efficacy was assessed by measuring tissue concentrations of steroid in maxillary sinus and nasal mucosa and by measurement of plasma steroid concentrations. Tolerance was assessed by histological evaluation of the sinus mucosa at different time points.Therapeutic mucosal drug concentrations were attained in a time-dependent fashion (range 175-28,189 ng/g). Plasma drug concentrations were generally near or below the lower limit of quantification (15 pg/mL). Histopathological examination of the mucosa showed no differences in the reaction to steroid-coated stents versus nondrug-coated control stents, with inflammation, epithelial ulceration, and bony reaction ranging from none to mild at all time points. Microscopic fungal hyphae were noted in a small proportion of both treatment and control sinuses, without evidence of associated adverse tissue reaction.In a rabbit model, mometasone-coated bioabsorbable stents are able to provide local steroid delivery with negligible systemic absorption. Corticosteroid-eluting stents may prove useful following endoscopic sinus surgery in maintaining sinus patency and reducing inflammation.

    View details for DOI 10.2500/ajra.2009.23.3391

    View details for Web of Science ID 000272677900009

    View details for PubMedID 19958608

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