Bio

Clinical Focus


  • Young Adults with Chronic Disease
  • Internal Medicine

Academic Appointments


Professional Education


  • Medical Education:Loyola University Chicago Stritch Sch Of Med (2005) IL
  • Board Certification: Pediatrics, American Board of Pediatrics (2009)
  • Board Certification: Internal Medicine, American Board of Internal Medicine (2009)
  • Residency:Harvard Medical School-Massachusetts General Hospital (2009) MA

Publications

Journal Articles


  • Regulation of avian cardiogenesis by Fgf8 signaling DEVELOPMENT Alsan, B. H., Schultheiss, T. M. 2002; 129 (8): 1935-1943

    Abstract

    The avian heart develops from paired primordia located in the anterior lateral mesoderm of the early embryo. Previous studies have found that the endoderm adjacent to the cardiac primordia plays an important role in heart specification. The current study provides evidence that fibroblast growth factor (Fgf) signaling contributes to the heart-inducing properties of the endoderm. Fgf8 is expressed in the endoderm adjacent to the precardiac mesoderm. Removal of endoderm results in a rapid downregulation of a subset of cardiac markers, including Nkx2.5 and Mef2c. Expression of these markers can be rescued by supplying exogenous Fgf8. In addition, application of ectopic Fgf8 results in ectopic expression of cardiac markers. Expression of cardiac markers is expanded only in regions where bone morphogenetic protein (Bmp) signaling is also present, suggesting that cardiogenesis occurs in regions exposed to both Fgf and Bmp signaling. Finally, evidence is presented that Fgf8 expression is regulated by particular levels of Bmp signaling. Application of low concentrations of Bmp2 results in ectopic expression of Fgf8, while application of higher concentrations of Bmp2 result in repression of Fgf8 expression. Together, these data indicate that Fgf signaling cooperates with Bmp signaling to regulate early cardiogenesis.

    View details for Web of Science ID 000175473800013

    View details for PubMedID 11934859

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