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S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia
Not Recruiting
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RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer
cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies,
such as gemtuzumab, can block cancer growth in different ways. Some find cancer cells and
help kill them or carry cancer-killing substances to them. Others interfere with the ability
of cancer cells to grow and spread. Gemtuzumab may also stop the growth of promyelocytic
leukemia by blocking blood flow to the cancer. Giving gemtuzumab together with combination
chemotherapy may be more effective in treating promyelocytic leukemia.
PURPOSE: This phase II trial is studying how well giving gemtuzumab together with combination
chemotherapy works in treating patients with previously untreated promyelocytic leukemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Nini Estevez, 6507254041.
Stanford Investigators
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A Randomized, Double-Blind, Placebo-Controlled Study of Idelalisib in Combination With Rituximab for Previously Treated Chronic Lymphocytic Leukemia (CLL)
Not Recruiting
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This Phase 3, randomized, double-blind, placebo-controlled study is to evaluate the effect of
idelalisib in combination with rituximab on the onset, magnitude, and duration of tumor
control in participants previously treated for chronic lymphocytic leukemia (CLL). Eligible
patients will be randomized with a 1:1 ratio into 1 of the 2 treatment arms to receive either
idelalisib plus rituximab or placebo plus rituximab. Participants who are tolerating primary
study therapy but experience definitive CLL progression are eligible to receive active
idelalisib therapy in the extension study, GS-US-312-0117.
Stanford is currently not accepting patients for this trial.
For more information, please contact Tessa Hunter, 6507364032.
Stanford Investigators
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A Study Being Conducted at Multiple Locations to Compare Safety and Efficacy of Three Different Regimens; (1) High-Dose Lenalidomide; (2) Lenalidomide + Azacitidine; or (3) Azacitidine in Subjects ≥ 65 Years With Newly-Diagnosed Acute Myeloid Leukemia
Not Recruiting
More
The study aim is to compare safety and efficacy of high-dose lenalidomide regimen, sequential
azacitidine and lenalidomide and an azacitidine in persons ≥65 years with newly-diagnosed
acute myeloid leukemia (AML).
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 6507232781.
Stanford Investigators
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To Demonstrate Superiority of Decitabine Over Azacitidine in Subjects With Intermediate- or High-risk MDS.
Not Recruiting
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The purpose of this study is to compare the response of patients with Intermediate or High
Risk myelodysplastic syndromes (MDS) following treatment with decitabine or azacitidine.
Stanford is currently not accepting patients for this trial.
For more information, please contact Mai Tran, 6507238594.
Stanford Investigators
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Azacitidine + Lenalidomide Combo in the Elderly With Previously Treated AML & High-Risk MDS
Not Recruiting
More
The purpose of the trial is to study how the elderly patients who have previously undergone
treatment for acute myeloid leukemia and high-rRisk myelodysplastic syndromes, respond to a
combined treatment with azacitidine and lenalidomide.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Lead Sponsor
Stanford Investigators
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A Study of Idelalisib and Rituximab in Elderly Patients With Untreated CLL or SLL
Not Recruiting
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This study is to evaluate the safety and clinical activity of idelalisib alone and in
combination with rituximab in patients with CLL or SLL.
This Phase 2 study will be the first time that idelalisib is administered to previously
untreated patients with hematologic malignancies. Idelalisib has demonstrated clinical
activity as a single agent in relapsed or refractory CLL and SLL with acceptable toxicity,
which supports its evaluation in previously untreated patients. The study population is
limited to patients over 65 years of age because younger patients are generally appropriate
for standard immunochemotherapy regimens that are highly active. Since the mechanism of
action of idelalisib is distinct from rituximab, it is hypothesized that the combination will
be more active than either agent alone. This study will establish initial safety and clinical
activity of idelalisib in combination with rituximab in patients with CLL or SLL. Cohort 2 of
this study will establish safety and clinical activity of idelalisib alone in subjects with
untreated CLL or SLL.
Stanford is currently not accepting patients for this trial.
For more information, please contact Nini Estevez, 6507254041.
Stanford Investigators
View full details
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Azacitidine With or Without Entinostat in Treating Patients With Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia
Not Recruiting
More
This randomized phase II trial studies azacitidine with or without entinostat to see how well
they work compared to azacitidine alone in treating patients with myelodysplastic syndromes,
chronic myelomonocytic leukemia, or acute myeloid leukemia. Drugs used in chemotherapy, such
as azacitidine, work in different ways to stop the growth of cancer cells, either by killing
the cells, by stopping them from dividing, or by stopping them from spreading. Entinostat may
stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Giving azacitidine together with entinostat may work better in treating patients with
myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Mai Tran, 6507238594.
Stanford Investigators
View full details
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Single Agent Lenalidomide in Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia
Not Recruiting
More
Time-to-Progression (TTP)
Stanford is currently not accepting patients for this trial.
For more information, please contact Leonel Gallegos, 6507232781.
Lead Sponsor
Stanford Investigators
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MLN4924 for the Treatment of Acute Myelogenous Leukemia, Myelodysplastic Syndrome, and Acute Lymphoblastic Leukemia
Not Recruiting
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An open-label, multicenter, phase 1, dose escalation study of MLN4924 in adult patients with
acute myelogenous leukemia (AML), high-grade myelodysplastic syndrome (MDS). The patient
population will consist of adults previously diagnosed with AML including high-grade MDS for
which standard curative, life-prolonging treatment does not exist or is no longer effective.
Stanford is currently not accepting patients for this trial.
For more information, please contact Leonel Gallegos, 6507232781.
Stanford Investigators
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Dose Escalation Study of CAL-101 in Select Relapsed or Refractory Hematologic Malignancies
Not Recruiting
More
The purpose of this study is to determine the dose that can be safely given to see what
effect it may have on your cancer and to determine how the drug is distributed in the body.
Stanford is currently not accepting patients for this trial.
For more information, please contact Michelle Takahashi, 6507364032.
Stanford Investigators
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Safety & Efficacy Study of Oral Panobinostat (LBH589) With Chemotherapy in Patients < 65 Years Old With Acute Myeloid Leukemia (AML)
Not Recruiting
More
This study will be conducted to assess the maximum tolerated dose (MTD) of panobinostat given
3 times a week (administered on weeks 2 and 3 of a 4 week cycle) in combination with
induction chemotherapy (idarubicin and cytarabine) in newly diagnosed patients with a
cytopathologically confirmed diagnosis of high-risk AML, and to investigate the safety of the
combination in this regimen.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 6507232781.
Stanford Investigators
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Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AML
Not Recruiting
More
The purpose of this study is to test the safety of vorinostat (Zolinza) and azacitidine
(Vidaza) when combined with gemtuzumab ozogamicin (GO) at different dose levels. These drugs
increase the effect of GO against leukemia cells in the test tube, but we don't know yet
whether they also increase the anti-leukemia effect of GO in people.
Stanford is currently not accepting patients for this trial.
For more information, please contact Leonel Gallegos, 6507232781.
Stanford Investigators
View full details
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COntrolled MyeloFibrosis Study With ORal JAK Inhibitor Treatment: The COMFORT-I Trial
Not Recruiting
More
This was a randomized, double-blind study comparing the efficacy and safety of ruxolitinib
(INCB018424) tablets to matching placebo tablets in patients diagnosed with Myelofibrosis
(either Primary Myelofibrosis (PMF) or Post-Polycythemia Vera Myelofibrosis (PPV-MF) or
Post-Essential Thrombocythemia Myelofibrosis (PET-MF).
Stanford is currently not accepting patients for this trial.
For more information, please contact Andrea Linder, 6507254047.
Stanford Investigators
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A Dose Escalation Study of Lenalidomide in Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia
Not Recruiting
More
The purpose of this study is to evaluate the safety of lenalidomide and to define the maximum
tolerated escalation dose level (MTEDL) when administered by a stepwise dose-escalation
schedule in subjects with relapsed or refractory B-cell CLL.
Stanford is currently not accepting patients for this trial.
For more information, please contact Michelle Takahashi, 6507364032.
Stanford Investigators
View full details
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Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)
Not Recruiting
More
This study seeks to (i) determine a safe and tolerated dose of CYT387 (momelotinib) given to
patients with PMF, post-PV or post-ET and, (ii) assess the effectiveness of
orally-administered CYT387 as a treatment for PMF, post-PV or post-ET.
Stanford is currently not accepting patients for this trial.
For more information, please contact Andrea Linder, 6507254047.
Stanford Investigators
View full details
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Bortezomib and Dexamethasone With or Without Lenalidomide in Treating Patients With Multiple Myeloma Previously Treated With Dexamethasone
Not Recruiting
More
This randomized phase III trial compares bortezomib, dexamethasone, and lenalidomide with
bortezomib and dexamethasone to see how well they work in treating patients with multiple
myeloma previously treated with dexamethasone. Bortezomib may stop the growth of cancer cells
by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as
dexamethasone, work in different ways to stop the growth of cancer cells, either by killing
the cells or by stopping them from dividing. Lenalidomide may stimulate the immune system in
different ways and stop cancer cells from growing. It is not yet known whether giving
bortezomib and dexamethasone is more effective with or without lenalidomide in treating
multiple myeloma.
Stanford is currently not accepting patients for this trial.
For more information, please contact Nancy Mori, 6507240201.
Stanford Investigators
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Phase 1-2 Amrubicin in Combo With Lenalidomide + Weekly Dexamethasone in Relapsed/Refractory Multiple Myeloma
Not Recruiting
More
To assess if amrubicin is safe and useful for patients with multiple myeloma requiring
additional treatment.
Stanford is currently not accepting patients for this trial.
For more information, please contact Kashif Naseem, 650-724-3155.
Stanford Investigators
View full details
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Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)
Not Recruiting
More
This extension protocol to the core study CCL09101 allows patients who have tolerated the
drug and derived a clinical benefit, to continue to receive treatment beyond the 9 cycles of
the core protocol. Long term safety and efficacy of CYT387 (momelotinib) will be evaluated.
Stanford is currently not accepting patients for this trial.
For more information, please contact Andrea Linder, 6507254027.
Stanford Investigators
View full details
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Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Not Recruiting
More
This phase II trial is studying the side effects of giving azacitidine together with
gemtuzumab ozogamicin to see how well it works in treating older patients with previously
untreated acute myeloid leukemia. Drugs used in chemotherapy, such as azacitidine, work in
different ways to stop the growth of cancer cells, either by killing the cells or by stopping
them from dividing. Azacitidine may also stop the growth of cancer cells by blocking some of
the enzymes needed for cell growth. Monoclonal antibodies, such as gemtuzumab ozogamicin, can
block cancer growth in different ways. Some block the ability of cancer cells to grow and
spread. Others find cancer cells and help kill them or carry cancer-killing substances to
them. Giving azacitidine together with gemtuzumab ozogamicin may kill more cancer cells.
Stanford is currently not accepting patients for this trial.
For more information, please contact Joselene Sipin-Sayno, 6507368113.
Stanford Investigators
View full details
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Temozolomide Plus Vorinostat in Relapse/Refractory Acute Myeloid Leukemia (AML)
Not Recruiting
More
The purpose of the study is to first determine if temozolomide plus vorinostat in combination
can control relapsed or refractory acute myeloid leukemia (AML) and determine if this
combination can be safely taken. The study will look at the side effects of the Temozolomide
plus Vorinostat in combination and whether the treatment schedule is tolerated.
Stanford is currently not accepting patients for this trial.
For more information, please contact Diana Dobbs, 650-736-6295.
Stanford Investigators
View full details
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Study of Lenalidomide to Evaluate Safety and Efficacy in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
Not Recruiting
More
The purpose of this study is to determine the safety and effectiveness of different dose
regimens of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia
(CLL).
Stanford is currently not accepting patients for this trial.
For more information, please contact Tessa Hunter, 6507364032.
Stanford Investigators
View full details
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Determination of Safe and Effective Dose of Romiplostim (AMG 531) in Subjects With Myelodysplastic Syndrome (MDS)Receiving Hypomethylating Agents
Not Recruiting
More
The purpose of this study is to evaluate the effect of Romiplostim (AMG 531) on the incidence
of clinically significant thrombocytopenic events (grade 3 or 4 and/or receipt of platelet
transfusions) in subjects with low or intermediate risk Myelodysplastic Syndrome (MDS)
receiving hypomethylating agents. It is hypothesized that Romiplostim administration, at the
appropriate dose and schedule, will result in reduction in the incidence of clinically
significant thrombocytopenic events in low or intermediate risk MDS subjects receiving
hypomethylating agents.
Stanford is currently not accepting patients for this trial.
For more information, please contact Mai Tran, 6507238594.
Stanford Investigators
View full details
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Panobinostat or Placebo With Bortezomib and Dexamethasone in Patients With Relapsed Multiple Myeloma
Not Recruiting
More
Panobinostat (LBH589) is a highly potent pan-deacetylase inhibitor (pan-DACi), inclusive of
HDAC6, which disrupts aggresome function, promotes accumulation of cytotoxic misfolded
protein aggregates and triggers myeloma cell death. Combination of pan-DAC and protease
inhibition by co-treatment with panobinostat (PAN) and bortezomib (BTZ) has demonstrated
synergistic cytotoxicity in vitro and in vivo in pre-clinical experiments. Furthermore,
clinical experience in advanced multiple myeloma (MM) patients treated by oral panobinostat
and i.v bortezomib ± dexamethasone showed very encouraging results for efficacy and
manageable toxicity profile.
Given the medical need for improved treatment strategies for patients with previously treated
and relapsed MM, the purpose of this prospective, multinational, randomized, double-blind,
placebo-controlled, parallel group Phase III study is to compare the results in
progression-free survival of 2 combination therapies, panobinostat with bortezomib and
dexamethasone or placebo with bortezomib and dexamethasone, in patients with previously
treated MM whose disease has recurred or progressed.
Stanford is currently not accepting patients for this trial.
For more information, please contact Nini Estevez, 6507254041.
Stanford Investigators
View full details
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Combination 5-azacitidine and Gemtuzumab Ozogamicin Therapy for Treatment of Relapsed Acute Myeloid Leukemia (AML)
Not Recruiting
More
This study will test an experimental combination of the drugs Mylotarg and 5-azacitidine in
the hopes of finding a treatment that may be effective against Acute Myeloid Leukemia that
has come back after treatment.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 6507232781.
Stanford Investigators
View full details
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Midostaurin in Treating Older Patients With Mutated Acute Myeloid Leukemia Post-Transplant
Not Recruiting
More
This phase 2 trial studies the side effects and how well midostaurin works in treating older
patients with acute myeloid leukemia with change in genetic material post-hematopoietic cell
transplantation. Midostaruin may stop the growth of cancer cells by blocking some of the
enzymes needed for cell growth. Giving midostaruin post-transplant may improve patient
outcomes.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Lead Sponsor
Stanford Investigators
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Evaluating the Safety of Long Term Dosing of Romiplostim (Formerly AMG 531) in Thrombocytopenic Subjects With Myelodysplastic Syndromes (MDS)
Not Recruiting
More
This is an open label extension study of romiplostim for treatment of thrombocytopenia
(platelet count ≤ 50 x 10^9/L) in MDS subjects. The study is designed to assess the long-term
safety of treatment with romiplostim, as measured by incidence of overall adverse events, the
incidence of bleeding events, the utilization of platelet transfusions, and the duration of
platelet response. The study will further describe the time to disease progression to acute
myeloid leukemia (AML) and survival.
Stanford is currently not accepting patients for this trial.
For more information, please contact Mai Tran, 6507238594.
Stanford Investigators
View full details
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Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia
Not Recruiting
More
This phase II trial is studying the side effects of giving combination chemotherapy together
with or without donor stem cell transplant and to see how well it works in treating patients
with acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop
the growth of cancer cells, either by killing the cells or by stopping them from dividing.
Giving more than one drug (combination chemotherapy) may kill more cancer cells. Giving
chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the
growth of cancer cells. It also stops the patient's immune system from rejecting the donor's
stem cells. The donated stem cells may replace the patient's immune cells and help destroy
any remaining cancer cells (graft-versus-tumor effect).
Stanford is currently not accepting patients for this trial.
For more information, please contact Vani Jain, 6507255459.
Stanford Investigators
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Ibrutinib, Idarubicin and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Not Recruiting
More
This phase I trial studies the side effects and best dose of ibrutinib when given together
with idarubicin and cytarabine in treating patients with acute myeloid leukemia that has
returned after a period of improvement or has not responded to previous treatment. Ibrutinib
may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Drugs used in chemotherapy, such as idarubicin and cytarabine, work in different ways to stop
the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by
stopping them from spreading. Giving ibrutinib together with idarubicin and cytarabine may
kill more cancer cells.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Stanford Investigators
View full details
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Liposomal Cytarabine-Daunorubicin CPX-351 in Treating Patients With Untreated Myelodysplastic Syndrome or Acute Myeloid Leukemia
Not Recruiting
More
This randomized clinical trial studies liposomal cytarabine-daunorubicin CPX-351 in treating
patients with untreated myelodysplastic syndrome or acute myeloid leukemia. Drugs used in
chemotherapy, such as liposomal cytarabine-daunorubicin CPX-351, work in different ways to
stop the growth of cancer cells, either by killing the cells, by stopping them from dividing,
or by stopping them from spreading.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Stanford Investigators
View full details
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Safety, Efficacy, & Pharmacokinetic Study of Tamibarotene to Treat Patients With Relapsed or Refractory APL
Not Recruiting
More
This is a Phase II, open-label, non-randomized study to evaluate the safety, efficacy, and
pharmacokinetics of tamibarotene in adult patients with relapsed or refractory acute
promyelocytic leukemia (APL) following treatment with all-trans-retinoic acid (ATRA) and
arsenic trioxide (ATO). Patients must have received and failed therapy with ATRA and ATO.
Treatment may have been administered either as combination therapy or sequentially as single
agents. Patients who are intolerant to either drug are eligible for this study.
Stanford is currently not accepting patients for this trial.
For more information, please contact Michelle Takahashi, 6507364032.
Stanford Investigators
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(QuANTUM-R): An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects Who Are FLT3-ITD Positive
Not Recruiting
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The primary objective of the study is to determine whether quizartinib monotherapy prolongs
overall survival (OS) compared to salvage chemotherapy in subjects with FMS-like tyrosine
kinase 3 - Internal Tandem Duplication (FLT3-ITD) positive AML who are refractory to or have
relapsed within 6 months, after first-line AML therapy.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Stanford Investigators
View full details
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CPX-351 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Not Recruiting
More
This phase 2 clinical trial studies how well CPX-351 (liposomal cytarabine-daunorubicin)
works in treating patients with relapsed or refractory acute myeloid leukemia or
myelodysplastic syndrome. Drugs used in chemotherapy, such as CPX-351, work in different ways
to stop the growth of cancer cells, either by killing the cells or by stopping them from
dividing.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Stanford Investigators
View full details
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Safety and Efficacy Study of Pracinostat With Azacitadine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)
Not Recruiting
More
The purpose of this study is to determine the safety and effectiveness of pracinostat when
combined with azacitadine for patients who are 65 years of age or older and have Acute
Myelogenous Leukemia (AML)
Stanford is currently not accepting patients for this trial.
For more information, please contact Leilani Hong Lien, 650-725-0437.
Stanford Investigators
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Efficacy and Safety of Midostaurin in Patients With Aggressive Systemic Mastocytosis or Mast Cell Leukemia
Not Recruiting
More
The purpose of this study was to determine the efficacy and safety of twice daily (bid) oral
midostaurin in patients with Aggressive Systemic Mastocytosis (ASM) or Mast Cell Leukemia
(MCL) with or without an Associated Hematological clonal Non-Mast cell lineage Disease
(AHNMD).
Stanford is currently not accepting patients for this trial.
For more information, please contact Andrea Linder, 6507254047.
Stanford Investigators
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Decitabine and Midostaurin in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Not Recruiting
More
This phase 2 study evaluates the sequential combination of decitabine then midostaurin for
the treatment of newly-diagnosed acute myeloid leukemia (AML) in older patients.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Stanford Investigators
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Study to Investigate Idelalisib in Combination With Chemotherapeutic Agents, Immunomodulatory Agents and Anti-CD20 Monoclonal Antibody (mAb) in Participants With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia
Not Recruiting
More
The primary objective of the study is to evaluate the safety of idelalisib in combination
with an anti-CD20 monoclonal antibody (mAb), a chemotherapeutic agent, a mammalian target of
rapamycin (mTOR) inhibitor, a protease inhibitor, an antiangiogenic agent, and/or an
immunomodulatory agent in participants with relapsed or refractory indolent B-cell
non-Hodgkin lymphoma (NHL), mantle cell lymphoma (MCL), or chronic lymphocytic leukemia
(CLL).
Stanford is currently not accepting patients for this trial.
For more information, please contact Nini Estevez, 650725-4041.
Stanford Investigators
View full details
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MEK Inhibitor MEK162, Idarubicin, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Not Recruiting
More
This phase I trial studies the MEK inhibitor MEK162 to see if it is safe in patients when
combined with idarubicin and cytarabine. MEK inhibitor MEK162 may stop the growth of cancer
cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy,
such as idarubicin and cytarabine, work in different ways to stop the growth of cancer cells,
either by killing the cells or by stopping them from dividing. Giving MEK inhibitor MEK162,
cytarabine, and idarubicin may be an effective treatment for acute myeloid leukemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack C. Taw, 650-723-2781.
Stanford Investigators
View full details
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Efficacy and Safety of Simtuzumab in Adults With Primary, Post Polycythemia Vera or Post Essential Thrombocythemia Myelofibrosis
Not Recruiting
More
This study is to evaluate the efficacy and safety of simtuzumab (GS-6624) on bone marrow
fibrosis either alone or in combination with ruxolitinib in participants with primary
myelofibrosis (PMF) and post polycythemia vera or post essential thrombocythemia
myelofibrosis (ET/PV MF).
The study is designed as a two-stage trial. In the stage 1, participants will be randomized
into two cohorts to receive either 200 or 700 mg of study drug. In the stage 2, participants
on ruxolitinib will be randomized to receive either 200 or 700 mg of study drug.
Stanford is currently not accepting patients for this trial.
For more information, please contact Andrea Linder, 6507254047.
Stanford Investigators
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Study of MLN4924 Plus Azacitidine in Treatment-naive Participants With Acute Myelogenous Leukemia (AML) Who Are 60 Years or Older
Not Recruiting
More
The purpose of this study is to establish the maximum tolerated dose (MTD), and to assess the
safety and tolerability of MLN4924 (pevonedistat) in combination with azacitidine in
treatment naive participants with AML who were 60 years of age or older.
Stanford is currently not accepting patients for this trial.
For more information, please contact Marlene Zuraek, (650) 736-4031.
Stanford Investigators
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A Study of Vismodegib in Patients With Relapsed/Refractory Acute Myelogenous Leukemia and Relapsed Refractory High-Risk Myelodysplastic Syndrome
Not Recruiting
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This study will assess the safety and efficacy of vismodegib in patients with
relapsed/refractory acute myelogenous leukemia (AML) and relapsed/refractory high-risk
myelodysplastic syndrome (MDS). Patients in Cohort 1 will receive single-agent vismodegib 150
mg orally daily. In Cohort 2, patients will receive vismodegib 150 mg orally daily in
combination with cytarabine 20 mg subcutaneously for 10 days.
Anticipated time on study treatment is until disease progression, intolerable toxicity, or
patient withdrawal of consent.
Stanford is currently not accepting patients for this trial.
For more information, please contact Marlene Zuraek, (650) 736-4031.
Stanford Investigators
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An Extension Study for Subjects Who Are Deriving Benefit With Idelalisib (GS-1101; CAL-101) Following Completion of a Prior Idelalisib Study
Not Recruiting
More
This is a long-term safety extension study of idelalisib (GS-1101; CAL-101) in patients with
hematologic malignancies who complete other idelalisib studies. It provides the opportunity
for patients to continue treatment as long as the patient is deriving clinical benefit.
Patients will be followed according to the standard of care as appropriate for their type of
cancer. The dose of idelalisib will generally be the same as the dose that was administered
at the end of the prior study, but may be titrated up to improve clinical response or down
for toxicity. Patients will be withdrawn from the study if they develop progressive disease,
unacceptable toxicity related to idelalisib, or if they no longer derive clinical benefit in
the opinion of the investigator.
Stanford is currently not accepting patients for this trial.
For more information, please contact Nini Estevez, 650-725-4041.
Stanford Investigators
View full details
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Ixazomib (MLN9708) in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Not Recruiting
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This phase 2 trial studies how well ixazomib(MLN9708) works in treating study participants
with relapsed or refractory acute myeloid leukemia. Ixazomib may stop the growth of cancer
cells by blocking some of the enzymes needed for cell growth.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-1269.
Stanford Investigators
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Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients With Previously Untreated Acute Myeloid Leukemia
Not Recruiting
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This randomized phase III trial studies cytarabine and daunorubicin hydrochloride or
idarubicin and cytarabine with or without vorinostat to see how well they work in treating
younger patients with previously untreated acute myeloid leukemia. Drugs used in
chemotherapy, such as cytarabine, daunorubicin hydrochloride, idarubicin, and vorinostat,
work in different ways to stop the growth of cancer cells, either by killing the cells,
stopping them from dividing, or by stopping from spreading. Giving more than one drug
(combination chemotherapy) and giving the drugs in different doses and in different
combinations may kill more cancer cells. It is not yet known which combination chemotherapy
is more effective in treating acute myeloid leukemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Joselene Sipin-Sayno, 650-736-8113.
Stanford Investigators
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Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia
Not Recruiting
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This randomized phase II/III trial studies how well azacitidine works with or without
lenalidomide or vorinostat in treating patients with higher-risk myelodysplastic syndromes or
chronic myelomonocytic leukemia. Drugs used in chemotherapy, such as azacitidine, work in
different ways to stop the growth of cancer cells, either by killing the cells, stopping them
from dividing, or by stopping them from spreading. Lenalidomide may stop the growth of cancer
cells by stopping blood flow to the cancer. Vorinostat may stop the growth of cancer cells by
blocking some of the enzymes needed for cell growth. It is not yet known whether azacitidine
is more effective with or without lenalidomide or vorinostat in treating myelodysplastic
syndromes or chronic myelomonocytic leukemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Joselene Sipin-Sayno, 650-736-8113.
Stanford Investigators
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Phase 1/2 Study of Enasidenib (AG-221) in Adults With Advanced Hematologic Malignancies With an Isocitrate Dehydrogenase Isoform 2 (IDH2) Mutation
Not Recruiting
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The primary objectives of Phase 1 Dose Escalation/Part 1 Expansion are:
- To assess the safety and tolerability of treatment with enasidenib administered
continuously as a single agent dosed orally on Days 1 to 28 of a 28-day cycle in
participants with advanced hematologic malignancies.
- To determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or
the recommended Phase 2 dose (RP2D) of enasidenib in participants with advanced
hematologic malignancies.
The primary objective of Phase 2 is:
• To assess the efficacy of enasidenib as treatment for participants with relapsed or
refractory (R/R) acute myelogenous leukemia (AML) with an IDH2 mutation.
Stanford is currently not accepting patients for this trial.
For more information, please contact Leilani Hong Lien, 650-725-0437.
Stanford Investigators
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A Phase 2 Study of ABT-199 in Subjects With Acute Myelogenous Leukemia (AML)
Not Recruiting
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This was a Phase 2, open-label, multicenter study evaluating the preliminary efficacy and
safety of venetoclax (ABT-199) administered orally in participants with acute myelogenous
leukemia (AML).
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Stanford Investigators
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Lenalidomide and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Not Recruiting
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This phase I trial studies the side effects and the best dose of lenalidomide when given
together with combination chemotherapy in treating patients with relapsed or refractory acute
myeloid leukemia. Lenalidomide may stop the growth of acute myeloid leukemia by blocking
blood flow to the cancer. Drugs used in chemotherapy, such as mitoxantrone hydrochloride,
etoposide, and cytarabine, work in different ways to stop the growth of cancer cells, either
by killing the cells or by stopping them from dividing. Giving lenalidomide and combination
chemotherapy may be an effective treatment for acute myeloid leukemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, 650-723-2781.
Lead Sponsor
Stanford Investigators
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A Study of Clofarabine and Cytarabine for Older Patients With Relapsed or Refractory Acute Myelogenous Leukemia (AML)(CLASSIC I)
Not Recruiting
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Clofarabine (injection) is approved by the Food and Drug Administration (FDA) for the
treatment of pediatric patients 1 to 21 years old with relapsed acute or refractory
lymphoblastic leukemia (ALL) who have had at least 2 prior treatment regimens.
There is no recommended standard treatment for relapsed or refractory acute myelogenous
leukemia in older patients. Cytarabine is the most commonly used drug to treat these
patients. This study will determine if there is benefit by combining clofarabine with
cytarabine. Patients will be randomized to receive up to 3 cycles of treatment with either
placebo in combination with cytarabine or clofarabine in combination with cytarabine.
Randomization was stratified by remission status following the first induction regimen (no
remission [i.e., CR1 = refractory] or remission <6 months vs CR1 = remission ≥6 months). CR1
is defined as remission after first pre-study induction regimen. The safety and tolerability
of clofarabine in combination with cytarabine and cytarabine alone will be monitored
throughout the study.
Stanford is currently not accepting patients for this trial.
For more information, please contact Richa Rajwanshi, 6507364031.
Stanford Investigators
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Phase 2 Study of Temozolomide to Treat Poor Risk / Refractory Acute Myeloid Leukemia
Not Recruiting
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Open-label, non-randomized, parallel assignment, phase 2 trial assessing the safety and
efficacy of distinct temozolomide treatment regimens for patients with AML and poor prognosis
Stanford is currently not accepting patients for this trial.
For more information, please contact Richa Rajwanshi, 6507364031.
Stanford Investigators
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Efficacy and Safety Study of Idelalisib in Participants With Indolent B-Cell Non-Hodgkin Lymphomas
Not Recruiting
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The primary objective will be to assess the overall response rate and to evaluate the
efficacy and safety of idelalisib (IDELA; GS-1101) in participants with previously treated
indolent Non-Hodgkin Lymphoma (iNHL) that is refractory both to rituximab and to
alkylating-agent-containing chemotherapy.
Eligible participants will initiate oral therapy with idelalisib at a starting dose of 150 mg
taken twice per day. Treatment with idelalisib can continue in compliant participants as long
as the study is still ongoing and the participants appear to be benefiting from treatment
with acceptable safety.
Stanford is currently not accepting patients for this trial.
For more information, please contact Tessa St.Rose, 6507364032.
Stanford Investigators
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Feasibility and Outcomes of Allogeneic HCT Compared to Chemotherapy in Older AML Patients
Not Recruiting
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The purpose of this study is to compare treatment methods and outcomes of patients diagnosed
with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
Stanford is currently not accepting patients for this trial.
For more information, please contact Jack Taw, CRC, 650-723-2781.
Stanford Investigators
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Study Comparing Carfilzomib, Lenalidomide, and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects With Relapsed Multiple Myeloma
Not Recruiting
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The primary objective was to compare progression-free survival in adults with relapsed
multiple myeloma who are receiving CRd vs participants receiving Rd in a randomized
multicenter setting.
Stanford is currently not accepting patients for this trial.
For more information, please contact Nini Estevez, 6507254041.
Stanford Investigators
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Phase II Study of VELCADE for Relapsed or Refractory T-cell Prolymphocytic Leukemia
Not Recruiting
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We hope to learn more about the clinical efficacy of bortezomib in T-cell prolymphocytic
leukemia. Patients will be selected as a possible participant in this study because they have
a bone marrow disorder known as T-cell prolymphocytic leukemia (T-cell PLL) which does not
tend to respond well to conventional treatment with chemotherapy.
Stanford is currently not accepting patients for this trial.
For more information, please contact Richa Rajwanshi, 6507364031.
Lead Sponsor
Stanford Investigators
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Extension Study of Idelalisib in Participants With Chronic Lymphocytic Leukemia (CLL) Who Participated in GS-US-312-0116 (NCT01539512)
Not Recruiting
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The primary objective of this extension study (GS-US-312-0117) that is a companion study to
Study GS-US-312-0116 (NCT01539512), is to evaluate the effect of idelalisib on the onset,
magnitude, and duration of tumor control. Randomization was done in study GS-US-312-0116, and
carried forward to study GS-US-312-117.
Stanford is currently not accepting patients for this trial.
For more information, please contact Tessa Hunter, 6507364032.
Stanford Investigators
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Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Not Recruiting
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The purpose of this study is to compare the effects, good and/or bad, of a standard
chemotherapy regimen for AML that includes the drugs daunorubicin and cytarabine combined
with or without midostaurin (also known as PKC412), to find out which is better. This
research is being done because it is unknown whether the addition of midostaurin to
chemotherapy treatment is better than chemotherapy treatment alone. Midostaurin has been
tested in over 400 patients and is being studied in a number of illnesses, including AML,
colon cancer, and lung cancer. Midostaurin blocks an enzyme, produced by a gene known as
FLT3, that may have a role in the survival and growth of AML cells. Not all leukemia cells
will have the abnormal FLT3 gene. This study will focus only on patients with leukemia cells
with the abnormal FLT3 gene.
Stanford is currently not accepting patients for this trial.
For more information, please contact Leonel Gallegos, 6507232781.
Stanford Investigators
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S0919 Idarubicin, Cytarabine, and Pravastatin in Treating Patients With Relapsed Acute Myeloid Leukemia
Not Recruiting
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RATIONALE: Drugs used in chemotherapy, such as idarubicin and cytarabine, work in different
ways to stop the growth of cancer cells, either by killing the cells or by stopping them from
dividing. Pravastatin may stop the growth of cancer cells by blocking some of the enzymes
needed for cell growth. Pravastatin may also help idarubicin and cytarabine work better by
making cancer cells more sensitive to the drugs. Giving idarubicin and cytarabine together
with pravastatin may kill more cancer cells.
PURPOSE: This phase II trial is studying how well giving idarubicin and cytarabine together
with pravastatin works in treating patients with relapsed acute myeloid leukemia (AML).
ADDITIONAL BACKGROUND: S0919 was initially designed for patients with relapsed acute myeloid
leukemia (AML), where the patient's preceding remission had lasted ≥ 3 months. The null
response rate was 30%. The study closed to accrual on Nov 1, 2012 after meeting the defined
criterion for a positive study; and the results are being submitted to the American Society
of Clinical Oncology meeting. Based on the promising results from this trial, the trial has
now been amended to evaluate this therapeutic regimen in poor-risk patients (patients with
newly diagnosed acute myeloid leukemia (AML) arising out of myelodysplastic syndrome (MDS),
primary refractory acute myeloid leukemia (AML), and relapsed acute myeloid leukemia (AML)
with the patient's preceding remission lasting < 6 months).
Stanford is currently not accepting patients for this trial.
For more information, please contact Joselene Sipin-Sayno, 650-736-8113.
Stanford Investigators
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Efficacy Study of Oral Sapacitabine to Treat Acute Myeloid Leukemia in Elderly Patients
Not Recruiting
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The objective is to treat elderly AML and MDS patients with sapacitabine.
Stanford is currently not accepting patients for this trial.
For more information, please contact Michelle Takahashi, 6507364032.
Stanford Investigators
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Phase II Study of AS1411 Combined With Cytarabine to Treat Acute Myeloid Leukemia
Not Recruiting
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The overall aim of this study is to assess the efficacy and safety of AS1411, over a range of
doses, when combined with cytarabine, in the treatment of patients with primary refractory or
relapsed acute myeloid leukemia (AML).
Stanford is currently not accepting patients for this trial.
For more information, please contact Richa Rajwanshi, 6507364031.
Stanford Investigators
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Allogeneic HCT Using Nonmyeloablative Host Conditioning With TLI & ATG vs SOC in AML
Not Recruiting
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Acute myeloid leukemia (AML) is a cancer of the bone marrow that mostly affects older adults.
Even with the best chemotherapy, two-year disease-free survival is achieved in a minority of
patients. Bone marrow transplantation from a sibling donor may improve cure rates; however,
patients over 50 years of age have a high risk of complications and therefore generally are
excluded from this treatment option. Recently our group developed a transplantation strategy
for older cancer patients that protects against transplant-associated complications, yet does
not interfere with the ability of the transplanted donor cells to destroy cancer cells. With
this new method, we can now safely evaluate transplantation as a curative therapy for AML
patients over the age of 50. We have assembled clinical and scientific researchers throughout
the state of California to study and compare bone marrow transplantation using our new
approach with the best standard of care chemotherapy in AML patients over the age of 50. The
results of this study have the potential to establish a new treatment standard that will
improve survival of older AML patients.
Stanford is currently not accepting patients for this trial.
For more information, please contact BMT Referrals, 650-725-1647.
Lead Sponsor
Stanford Investigators
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Compare Bosutinib To Imatinib In Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive CML
Not Recruiting
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Two-arm, randomized, open-label trial designed to evaluate the efficacy and safety of
bosutinib alone compared to imatinib alone in subjects newly diagnosed with chronic phase
Chronic Myelogenous Leukemia (CML). The primary endpoint is cytogenetic response rate at one
year.
Stanford is currently not accepting patients for this trial.
For more information, please contact Michelle Takahashi, 6507364032.
Stanford Investigators
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Phase III Study of CPX-351 Versus 7+3 in Patients 60-75 Years Old With Untreated High Risk (Secondary) Acute Myeloid Leukemia
Not Recruiting
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To confirm the efficacy of CPX-351 compared to 7+3 as first line therapy in elderly patients
(60-75 yrs) with high risk (secondary) Acute Myeloid Leukemia. The primary efficacy endpoint
will be overall survival.
Stanford is currently not accepting patients for this trial.
For more information, please contact Marlene Zuraek, 6507364031.
Stanford Investigators
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Safety Study of CAT-8015 Immunooxin in Patients With HCL With Advance Disease
Not Recruiting
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RATIONALE: The CAT-8015 immunotoxin can bind tumor cells and kill them without harming normal
cells. This may be an effective treatment for hairy cell leukemia(HCL) that has not responded
to chemotherapy, surgery or radiation therapy.
PURPOSE: Phase I dose escalation study to determine the maximum tolerated dose of CAT-8015
immunotoxin in treating patients who have hairy cell leukemia (HCL) that has not responded to
treatment.
Stanford is currently not accepting patients for this trial.
For more information, please contact Michelle Takahashi, 6507364032.
Stanford Investigators
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Study to Determine the Maximum Tolerated Dose and Evaluate the Efficacy and Safety of CEP-18770 (Delanzomib) in Patients With Relapsed Multiple Myeloma Refractory to the Most Recent Therapy
Not Recruiting
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The primary objective for part 1 of the study is to determine the maximum tolerated dose
(MTD) of CEP-18770 in patients with relapsed and refractory multiple myeloma. The primary
objective for part 2 is to evaluate the antitumor activity of CEP-18770 in patients treated
at the MTD.
Stanford is currently not accepting patients for this trial.
For more information, please contact Leonel Gallegos, 6507232781.
Stanford Investigators
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Phase I Bortezomib (VELCADE) in Combo With Pralatrexate in Relapsed/Refractory MM
Not Recruiting
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The purpose of this trial is to find out the maximum tolerated dose (MTD) of bortezomib
(VELCADE) in combination with pralatrexate in patients with previously treated multiple
myeloma, AL amyloid and Waldenstroem's macroglobulinemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Ying Hao, 650-723-0646.
Lead Sponsor
Stanford Investigators
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Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Not Recruiting
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RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer
cells, either by killing the cells or by stopping them from dividing. Giving more than one
drug (combination chemotherapy) may kill more cancer cells.
PURPOSE: This phase II trial is studying how well combination chemotherapy works in treating
young patients with newly diagnosed acute lymphoblastic leukemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Joselene Sipin-Sayno, 6507368113.
Stanford Investigators
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Phase 1-2 of Azacitidine + Lenalidomide for Previously Untreated Elderly Patients With Acute Myeloid Leukemia (AML)
Not Recruiting
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This study has a phase 1 and a phase 2 component.
In phase 1, the objective is to determine the maximum tolerated dose (MTD) of lenalidomide
when after azacitidine.
In phase 2, the objective is to determine the efficacy of the combination treatment.
Stanford is currently not accepting patients for this trial.
For more information, please contact Leonel Gallegos, 6507232781.
Lead Sponsor
Stanford Investigators
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A Long-Term Study of the Effects of Orally Administered SAR302503 in Patients With Myelofibrosis
Not Recruiting
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The purpose of this study is to evaluate the long-term effects of orally administered
SAR302503 (TG101348) in patients with myelofibrosis who have completed the MF-TG101348-001
study.
Stanford is currently not accepting patients for this trial.
For more information, please contact Andrea Linder, 6507254047.
Stanford Investigators
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Study to Determine Efficacy and Safety of Lenalidomide Plus Low-dose Dexamethasone Versus Melphalan, Prednisone, Thalidomide in Patients With Previously Untreated Multiple Myeloma
Not Recruiting
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The purpose of this study is to compare the safety and efficacy of Lenalidomide plus low dose
dexamethasone to that of the combination of melphalan, prednisone and thalidomide.
Stanford is currently not accepting patients for this trial.
For more information, please contact Nini Estevez, 6507254041.
Stanford Investigators
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S0910 Epratuzumab, Cytarabine, and Clofarabine in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
Not Recruiting
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RATIONALE: Monoclonal antibodies, such as epratuzumab, can block cancer growth in different
ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and
help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such
as cytarabine and clofarabine, work in different ways to stop the growth of cancer cells,
either by killing the cells or by stopping them from dividing. Giving epratuzumab together
with cytarabine and clofarabine may kill more cancer cells.
PURPOSE: This phase II trial is studying the side effects and how well giving epratuzumab
together with cytarabine and clofarabine works in treating patients with relapsed or
refractory acute lymphoblastic leukemia.
Stanford is currently not accepting patients for this trial.
For more information, please contact Nini Estevez, 6507254041.
Stanford Investigators
View full details
