Bruce Koch, Ph.D.

Director, High-Throughput Screening

Current Role at Stanford

Head, ChEM-H/CSB High Throughput Screening Knowledge Center (HTSKC)<br/>Staff Co-lead, IMA HTS Module<br/><br/>Adviser to the SPARK Program

Supervisors

Carolyn Bertozzi

Academic Appointments

Senior Research Scientist, Sarafan ChEM-H

Boards, Advisory Committees, Professional Organizations

Committee Member, NIH Study Section (Drug Discovery for Aging, Neuropsychiatric and Neurologic Disorders (SBIR/STTR)) (2014 - 2018)
Committee Member, NIH Study Section (NIH Roadmap HTS Assay for MLPCN R03) (2010 - 2010)
Committee Member, NIH Study Section (NIH Roadmap Assay Development R25) (2009 - 2009)
Committee Member, National Academy of Sciences Ohio BRTT Committee (2003 - 2003)
Member, Biophysical Society (1995 - Present)
Member, Society for Laboratory Automation and Screening (1999 - Present)
Member, Association of Biomolecular Resource Facilities (2012 - Present)

Professional Education

Post-doc, UC Berkeley, Biochemistry (PI: Randy Schekman)
Ph.D., Harvard Medical School, Cell and Developmental Biology (1986)
B.S., Bates College, Biology (1979)

Patents

P.S. Dietrich, B. Koch, H. Guthrie, U. A. Gubler. "United States Patent 8,349,572 Stable cell lines expressing hERG", Roche Palo Alto LLC, Jan 8, 2013
P.S. Dietrich, B. Koch, H. Guthrie, U. A. Gubler. "United States Patent 7,776,590B2 Stable cell lines expressing hERG", Roche Palo Alto LLC, Aug 17, 2010

All Publications

Profiles With Related Publications

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Timothy Angelotti MD, PhD

Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Clinical Focus
Critical Care, Anesthesia
Research Interests
My research efforts are focused on investigating the pharmacological and physiological interface of the autonomic nervous system with effector organs. Utilizing molecular, cellular, and electrophysiological techniques, we are examining alpha2 adrenergic receptor function in cultured sympathetic neurons. Future research aims will be directed toward understanding neurotransmitter release in general.

56 Total Publications
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Edward Bertaccini

Professor of Anesthesiology, Perioperative and Pain Medicine
Research Interests
molecular modeling of anesthetic-protein interactions, molecular modeling of the ligand-gated ion channels

88 Total Publications
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Patrick O. Brown

Professor of Biochemistry, Emeritus
Research Interests
Dr. Brown, currently an emeritus professor, is CEO and founder of Impossible Foods, a company dedicated to replacing the world's most destructive technology - the use of animals to transform plant biomass into meat, fish and dairy foods - by developing a new and better way to produce the world's most delicious, nutritious and affordable meats, fish and dairy foods directly from plants. Visit impossiblefoods.com for more information.

319 Total Publications
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William Clusin, MD

Associate Professor of Medicine (Cardiovascular Medicine)
Research Interests
Cardiac action potentials; tissue culture, voltage, clamp technique; role of calcium in ischemia arrhythmias; coronary, artery disease; myocardial infarction.

53 Total Publications
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Luis de Lecea

Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical and Translational Neurosciences Incubator)
Research Interests
My lab uses molecular, optogenetic, anatomical and behavioral methods to identify and manipulate the neuronal circuits underlying brain arousal, with particular attention to sleep and wakefulness transitions. We are also interested in the changes that occur in neuronal circuits in conditions of hyperarousal such as stress and drug addiction.

210 Total Publications
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James Ferrell

Professor of Chemical and Systems Biology and of Biochemistry
Research Interests
My lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.

147 Total Publications
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Uta Francke

Professor of Genetics and of Pediatrics, Emerita
Clinical Focus
Neurogenetics, Clinical Genetics, Marfan syndrome, Williams syndrome, Heritable connective tissue disorders
Research Interests
Functional consequences and pathogenetic mechanisms of mutations and microdeletions in human neurogenetic syndromes and mouse models. Integration of genomic information into medical care.

564 Total Publications
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Neil Gesundheit

Senior Associate Dean for Medical Education, George DeForest Barnett Founders Professor of Medicine and Professor (Teaching) of Medicine (Endocrinology)
Clinical Focus
Endocrinology, Thyroid disorders, Endocrinology / Diabetes, Diabetes and Metabolism
Research Interests
Our medical education research group is developing and validating the best educational practices to train competent, compassionate, and ethical physicians and physician-scientists. We are studying the use of standardized patients and other modalities to improve clinical skill training and reasoning. We are interested in applying the rigor of clinical investigation to education research.

My areas of clinical interest in endocrinology include disorders of the pituitary, thyroid, and gonad.

73 Total Publications
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Rona Giffard

Professor of Anesthesiology, Perioperative and Pain Medicine, Emerita
Research Interests
Astrocytes, microglia and neurons interact, and have unique vulnerabilities to injury based on their patterns of gene expression and their functional roles. We focus on the cellular and molecular basis of brain cell injury in stroke. We study the effects of altering miRNA expression, altering levels of heat shock and cell death regulatory proteins. Our goal is to improve outcome by improving mitochondrial function and brain cell survival, and reducing oxidative stress and inflammation.

179 Total Publications
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Miriam B. Goodman

Mrs. George A. Winzer Professor of Cell Biology
Research Interests
We study the molecular events that give rise to the sensation of touch and temperature in C. elegans. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. We also collaborate with Pruitt's group in Mechanical Engineering to develop and fabricate novel devices for the study of sensory transduction.

110 Total Publications
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John Huguenard

Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology
Research Interests
We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks.

211 Total Publications
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Ron Kopito

Professor of Biology
Research Interests
Our laboratory use state-of-the-art cell biological, genetic and systems-level approaches to understand how proteins are correctly synthesized, folded and assembled in the mammalian secretory pathway, how errors in this process are detected and how abnormal proteins are destroyed by the ubiquitin-proteasome system.

125 Total Publications