School of Medicine
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Professor of Genetics and, by courtesy, of Statistics
Current Research and Scholarly Interests Develop statistical and computational methods for population genomics analyses; modeling human evolutionary history; genetic association studies in admixed populations.
Jean Y. Tang MD PhD
Professor of Dermatology at the Stanford University Medical Center
Current Research and Scholarly Interests My research focuses on 2 main areas:
1. Skin cancer:
- New therapeutics to treat and prevent non-melanoma skin cancer, especially by targeting the Hedgehog signaling pathway for BCC tumors
- Genomic analysis of drug-resistant cancers
- Identifying risk factors for skin cancer in the Women's Health Initiative
2. Epidermolysis Bullosa: gene therapy and protein therapy to replace defective/absent Collagen 7 in children and adults with Recessive Dystrophic EB
Melinda L. Telli, M.D.
Associate Professor of Medicine (Oncology) at the Stanford University Medical Center
Current Research and Scholarly Interests My research focuses on the development of novel therapies for the treatment of triple-negative and hereditary cancer. Other areas of interest include prevention of cardiac damage associated with breast cancer treatment and cardiotoxicity of anti-cancer agents.
Professor of Obstetrics and Gynecology (Oncology)
Current Research and Scholarly Interests Gynecologic Malignancies
Biologic Response Modifiers
New Drug Development
Antigenic specificities of human antibodies encoded by the VH4-34 gene
Assistant Professor of Radiology (Pediatric Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Over the past decade there has been tremendous advances in the field of Interventional Oncology with the clinical utilization of multiple new innovative locoregional therapies (i.e. chemoembolization, percutaneous ablation).
Looking forward, our ability to super-selectively deliver new therapies directly to target organs. These therapies include nanoparticles, stem cells and gene therapy and will open new pathways into the emerging field of Interventional Regenerative Medicine.
Reena Thomas, MD PhD
Clinical Associate Professor, Neurology & Neurological Sciences
Current Research and Scholarly Interests -Neuro Oncology Immunotherapy
Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly Interests My research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly Interests We develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.
Matt van de Rijn
Sabine Kohler, MD, Professor in Pathology
Current Research and Scholarly Interests Our research focuses on molecular analysis of human soft tissue tumors (sarcomas) with an emphasis on leiomyosarcoma and desmoid tumors. In addition we study the role of macrophages in range of malignant tumors.
Capucine van Rechem
Assistant Professor of Pathology (Pathology Research)
Current Research and Scholarly Interests My long-term interest lies in understanding the impact chromatin modifiers have on disease development and progression so that more optimal therapeutic opportunities can be achieved. My laboratory explores the direct molecular impact of chromatin-modifying enzymes during cell cycle progression, and characterizes the unappreciated and unconventional roles that these chromatin factors have on cytoplasmic function such as protein synthesis.
Assistant Professor of Comparative Medicine at the Stanford University Medical Center
Bio Dr. José G. Vilches-Moure, DVM, PhD, Assistant Professor, received his DVM degree from Purdue University in Indiana in 2007. He completed his residency training in Anatomic Pathology (with emphasis in pathology of laboratory animal species) and his PhD in Comparative Pathology at the University of California-Davis. He joined Stanford in 2015, and is the Director of the Animal Histology Services (AHS). Dr. Vilches-Moure is a diplomate of the American College of Veterinary Pathologists, and his collaborative research interests include cardiac development and pathology, developmental pathology, and refinement of animal models in which to study early cancer detection techniques. His teaching interests include comparative anatomy/histology, general pathology, comparative pathology, and pathology of laboratory animal species.
Hannes Vogel MD
Professor of Pathology and of Pediatrics (Pediatric Genetics) and, by courtesy, of Neurosurgery and of Comparative Medicine at the Stanford University Medical Center
Current Research and Scholarly Interests My research interests include nerve and muscle pathology, mitochondrial diseases, pediatric neurooncology, and transgenic mouse pathology.
Associate Professor (Research) of Surgery (Health Services Research Unit)
Bio Todd Wagner is an Associate Professor in the Department of Surgery at Stanford University. He studies health information, efficiency and value, and health care access. He is particularly interested in developing learning health care systems that provide high value care. In addition to his role at Stanford, he Directs the Health Economics Resource Center and is the Associate Director for the Center for Innovation to Implementation, both at the Palo Alto VA. He also co-directs the VA/NCI Big Data Fellowship.
Professor of Medicine (Oncology) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Wakelee's research is focused on clinical trials and translational efforts in patients with lung cancer and other thoracic malignancies such as thymoma and thymic carcinoma. Other interests include translation projects in thoracic malignancies and collaborations with population scientists regarding lung cancer questions.
Professor of Chemical and Systems Biology and, by courtesy, of Chemistry
Current Research and Scholarly Interests We employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. We invent tools for biology and we are motivated by approaches that enable new experiments with unprecedented control. These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. Protein quality control is a particular interest at present.
Kevin Wang, MD, PhD
Assistant Professor of Dermatology
Current Research and Scholarly Interests The Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation.
Shan X. Wang
Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly Interests Shan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.
Klaus Bensch Professor in Experimental Pathology, Emerita
Current Research and Scholarly Interests The main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication.
Irene Wapnir, MD
Professor of Surgery (General Surgery) at the Stanford University Medical Center
Current Research and Scholarly Interests Clinical trials in operative procedures such as Nipple-sparing mastectomy, arm lymphatic mapping, skin perfusion and Treatments for Breast Cancer, especially local recurrence. Dr. Wapnir is institutional Principal Investigator and Chair for National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trials. Laboratory and translational research includes exploring the activity of breast iodide transporter in breast cancer brain metastasis.
Ronald F. Dorfman, M.B.B.ch., FRCPath, Professor in Hematopathology, Emeritus
Current Research and Scholarly Interests As an Emeritus Professor, I no longer have a research laboratory and devote my 10% voluntary effort to lymphoma diagnosis and teaching. I do devote a small amount of effort to lymphoma research in collaboration with Yaso Natkunam and others in the Department of Pathology.
William M. Hume Professor in the School of Medicine, Professor of Structural Biology, of Molecular and Cellular Physiology and of Photon Science
Current Research and Scholarly Interests Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our principal areas of interest are the architecture and dynamics of intercellular adhesion junctions, signaling pathways that govern cell fate determination, and determinants of cell polarity. Our overall approach is to reconstitute macromolecular assemblies with purified components in order to analyze them using biochemical, biophysical and structural methods.
Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology
Current Research and Scholarly Interests Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.
Francis W. Bergstrom Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Molecular imaging, therapeutics, drug delivery, drug mode of action, synthesis
Wen-Kai Weng, MD, PhD
Associate Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy) and, by courtesy, of Dermatology at the Stanford University Medical Center
Current Research and Scholarly Interests My research interest is on immunotherapy (including allogeneic transplant) of cancer. I have studies the mechanism of monoclonal antibody therapy in lymphoma patients and am currently working on designing new strategy to enhance the clinical efficacy of antibody therapy by infusing expanded NK cells. I am also interested in using tumor vaccine along with hematopoietic cell transplant.
Professor of Pathology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Epigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine
Professor of Pathology at the Stanford University Medical Center
Current Research and Scholarly Interests Rob West, MD, PhD, is a Professor of Pathology at Stanford University Medical Center. He is a clinician scientist with experience in translational genomics research to identify new prognostic and therapeutic markers in cancer. His research focus is on the progression of neoplasia to carcinoma. His lab has developed spatially oriented in situ methods to study archival specimens. He also serves as a surgical pathologist specializing in breast pathology.
Lynn Marie Westphal, M.D.
Professor of Obstetrics and Gynecology (Reproductive Endocrinology and Infertility) at Stanford University Medical Center, Emerita
Current Research and Scholarly Interests Infertility, fertility preservation, oocyte cryopreservation
Associate Professor of Genetics and of Pathology
Current Research and Scholarly Interests Our laboratory uses genome-wide methods to uncover alterations that drive cancer progression and metastasis in genetically-engineered mouse models of human cancers. We combine cell-culture based mechanistic studies with our ability to alter pathways of interest during tumor progression in vivo to better understand each step of metastatic spread and to uncover the therapeutic vulnerabilities of advanced cancer cells.
Professor of Radiology (Neuroimaging and Neurointervention) and, by courtesy, of Neurology, of Neurosurgery and of Psychiatry and Behavioral Sciences at the Stanford University Medical Center
Current Research and Scholarly Interests Stroke, cerebrovascular diseases, cardiovascular diseases, carotid arteries, coronary arteries
Stroke diagnosis, stroke triage, stroke treatment
Traumatic brain injury
Traumatic brain injury diagnosis and prognosis
Psychiatric disorders, including depression and post-traumatic stress disorders
Movement disorders, including essential tremor and Parkinson’s tremor
Image-guided clinical trials
CT, multidetector-row CT, perfusion-CT, CT angiography
MRI, diffusion-weighted MRI, perfusion-weighted MRI, diffusion tensor imaging, functional MRI
Brain perfusion imaging techniques
Post-processing techniques of medical images, signal and image processing
MR-guided focused ultrasound
Albert J. Wong, M.D.
Professor of Neurosurgery
Current Research and Scholarly Interests Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective.
Wing Hung Wong
Stephen R. Pierce Family Goldman Sachs Professor in Science and Human Health and Professor of Biomedical Data Science
Current Research and Scholarly Interests Current interest centers on the application of statistics to biology and medicine. We are particularly interested in questions concerning gene regulation, genome interpretation and their applications to precision medicine.
Albert Y. Wu, MD, PhD, FACS
Assistant Professor of Ophthalmology at the Stanford University Medical Center
Current Research and Scholarly Interests My translational research focuses on using autologous stem cells to recreate a patient’s ocular tissues for potential transplantation. We are generating tissue from induced pluripotent stem cells to treat limbal stem cell deficiency in patients who are bilaterally blind. By applying my background in molecular and cellular biology, stem cell biology, oculoplastic surgery, I hope to make regenerative medicine a reality for those suffering from orbital and ocular disease.
Joseph C. Wu
Director, Stanford Cardiovascular Institute, Simon H. Stertzer, MD, Professor and Professor of Radiology
Current Research and Scholarly Interests Drug discovery, drug screening, and disease modeling using biobank of cardiac iPSC lines.
Associate Professor of Medicine (Endocrinology)
Current Research and Scholarly Interests My laboratory focuses on the pathways that regulate the differentiation of mesenchymal stem cells into the osteoblast and adipocyte lineages. We are also studying the role of osteoblasts in the hematopoietic and cancer niches in the bone marrow microenvironment.
Lorry Lokey Professor and Professor of Developmental Biology
Current Research and Scholarly Interests The precise and robust regulation of gene expression is a cornerstone for complex biological life. Research in our laboratory is focused on understanding how regulatory information encoded by the genome is integrated with the transcriptional machinery and chromatin context to allow for emergence of form and function during human embryogenesis and evolution, and how perturbations in this process lead to disease.
Jacob Haimson Professor and Professor, by courtesy, of Electrical Engineering
Current Research and Scholarly Interests artificial intelligence in medicine, Image-guided intervention, molecular imaging, biologically conformable radiation threapy (BCRT), treatment plan optimization, optimization, application of molecular imaging to radiation oncology.
Assistant Professor of Radiation Oncology
Current Research and Scholarly Interests One hallmark of cancer is that malignant cells modulate metabolic pathways to promote cancer progression. My professional interest is to investigate the causes and consequences of the abnormal metabolic phenotypes of cancer cells in response to microenvironmental stresses such as hypoxia and nutrient deprivation, with the prospect that therapeutic approaches might be developed to target these metabolic pathways to improve cancer treatment.
Lisa Zaba, MD, PhD
Clinical Associate Professor, Dermatology
Bio Lisa Zaba M.D. Ph.D., is Clinical Associate Professor of Dermatology and Director of the South Bay Cutaneous Oncology Program. She has a special interest in managing skin complications in cancer patients while they receive treatment including skin rashes, graft versus host disease, and skin cancer. She also has a special interest in rheumatologic diseases and autoimmunity that can be caused by some forms of immune based chemotherapeutics. At the South Bay Cancer Center (CCSB) she leads the multi-disciplinary melanoma clinic. Dr. Zaba completed medical school at Cornell University, PhD in immunology at Rockefeller University, Residency and Post-Doc at Stanford University in 2013.
Marguerite Blake Wilbur Professor in Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly Interests My research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells.
James L. Zehnder, M.D.
Professor of Pathology (Research) and of Medicine (Hematology) at the Stanford University Medical Center
Current Research and Scholarly Interests Our laboratory focuses on translational research in 2 main areas - genomic approaches to diagnosis and minimal residual disease testing for patients with cancer, and molecular basis of disorders of thrombosis and hemostasis. My clinical focus is in molecular pathology, diagnosis and treatment of disorders of hemostasis and thrombosis and general hematology.