School of Medicine
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Jean Y. Tang MD PhD
Professor of Dermatology at the Stanford University Medical Center
Current Research and Scholarly Interests My research focuses on 2 main areas:
1. Skin cancer:
- New therapeutics to treat and prevent non-melanoma skin cancer, especially by targeting the Hedgehog signaling pathway for BCC tumors
- Genomic analysis of drug-resistant cancers
- Identifying risk factors for skin cancer in the Women's Health Initiative
2. Epidermolysis Bullosa: gene therapy and protein therapy to replace defective/absent Collagen 7 in children and adults with Recessive Dystrophic EB
Professor of Neurosurgery
Bio Dr. Peter Tass investigates and develops neuromodulation techniques for understanding and treating neurologic conditions such as Parkinson’s disease, epilepsy, dysfunction following stroke and tinnitus. He creates invasive and non-invasive therapeutic procedures by means of comprehensive computational neuroscience studies and advanced data analysis techniques. The computational neuroscience studies guide experiments that use clinical electrophysiology measures, such as high density EEG recordings and MRI imaging, and various outcome measures. He has pioneered a neuromodulation approach based on thorough computational modelling that employs dynamic self-organization, plasticity and other neuromodulation principles to produce sustained effects after stimulation. To investigate stimulation effects and disease-related brain activity, he focuses on the development of stimulation methods that cause a sustained neural desynchronization by an unlearning of abnormal synaptic interactions. He also performs and contributes to pre-clinical and clinical research in related areas.
Joyce Teng, MD, PhD
Professor of Dermatology at the Lucile Salter Packard Children's Hospital
Bio Joyce Teng, MD, PhD is a professor in dermatology at Stanford University. She is affiliated with multiple hospitals in the area, including Lucile Salter Packard Children's Hospital (LPCH) at Stanford and Stanford Hospital and Clinics (SHC). She received her medical degree from Vanderbilt University School of Medicine and has been in practice for more than 12 years. She is one of the 5 pediatric dermatologists practicing at LPCH and one of 72 at SHC who specialize in Dermatology. She sees patients with rare genetic disorders, birthmarks, vascular anomalies and a variety of inflammatory skin diseases. She is also an experienced pediatric dermatological surgeon. Her research interests are drug discovery and novel therapy for skin disorders.
Assistant Professor of Radiology (Pediatric Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Over the past decade there has been tremendous advances in the field of Interventional Oncology with the clinical utilization of multiple new innovative locoregional therapies (i.e. chemoembolization, percutaneous ablation).
Looking forward, our ability to super-selectively deliver new therapies directly to target organs. These therapies include nanoparticles, stem cells and gene therapy and will open new pathways into the emerging field of Interventional Regenerative Medicine.
Assistant Professor of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests The long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of “suites” of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.
Clinical Professor, Psychiatry and Behavioral Sciences - Child and Adolescent Psychiatry
Current Research and Scholarly Interests Pediatric Acute-Onset Neuropsychiatric Disorder
Reena Thomas, MD PhD
Clinical Associate Professor, Neurology & Neurological Sciences
Current Research and Scholarly Interests -Neuro Oncology Immunotherapy
Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly Interests My research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.
Associate Professor of Pediatrics (Cardiology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Assessment of vascular health s in children by non-invasive modalities
Echocardiography and outcomes in congenital heart disease
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly Interests We develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.
Assistant Professor (Research) of Pediatrics (Developmental-Behavioral Pediatrics)
Bio Dr. Katherine Travis is an Assistant Professor in the Division of Developmental-Behavioral Pediatrics at Stanford University. Dr. Travis obtained her Ph.D. in Neuroscience from the University of California San Diego. Dr. Travis came to Stanford as a postdoctoral fellow to obtain training in clinical neuroscience and translational approaches to intervention. As part of her training, she was awarded a K99/R00 Pathway to Independence grant from the National Institutes of Health.
Her research uses human neuroimaging and behavioral measures to examine the neural bases of early language learning in infants and young children. The goal of her research is to develop therapies and interventions to help promote language learning outcomes in children at-risk for learning disabilities. Currently, she directs an NIH-funded clinical trial that will use diffusion MRI to assess whether there are changes in brain structure following a language intervention in the Neonatal Intensive Care Unit for preterm infants.
Susan P. and Riley P. Bechtel Medical Director and Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Tremmel studies sex differences in cardiovascular disease. Current research projects include evaluating sex differences in coronary pathophysiology, young patients presenting with myocardial infarction, the impact of stress on anginal symptoms, chronic total coronary occlusions, and vascular access site complications.
Philip S. Tsao, PhD
Professor (Research) of Medicine (Cardiovascular Medicine)
Current Research and Scholarly Interests Our primary interests are in the molecular underpinnings of vascular disease as well as assessing disease risk. In addition to targeted investigation of specific signaling molecules, we utilize global genomic analysis to identify gene expression networks and regulatory units. We are particularly interested in the role of microRNAs in gene expression pathways associated with disease.
Chi-Ho Ban Tsui
Professor of Anesthesiology, Perioperative and Pain Medicine (Adult-MSD) at the Stanford University Medical Center
Bio Dr. Tsui completed his medical training at Dalhousie University, Halifax, in 1995 after obtaining his Masters of Science in Pharmacy in 1991. These degrees followed a Diploma in Engineering and Bachelors of Science in both Mathematics and Pharmacy. Dr. Tsui completed his anesthesia residency training at the University of Alberta Hospital in Edmonton in 2000, and he received further experience in pediatric anesthesia at British Columbia Children's Hospital in Vancouver. After 16 years of practice at the University of Alberta Hospital and Stollery Children’s Hospital, Dr. Tsui was recruited to Stanford University.
Currently, Dr. Tsui is a Medical Center Line (MCL) Professor in the Department of Anesthesiology, Perioperative and Pain Medicine at Stanford University. In his position as an adult and pediatric anesthesiologist at the Stanford University Medical Center and the Lucile Packard Children’s Hospital, he specializes in regional anesthesia techniques.
Dr. Tsui is an avid and internationally recognized researcher in many areas of regional anesthesia. During his residency, Dr. Tsui developed an interest in improving the accuracy of epidural catheter placement and was issued a U.S. patent in relation to his research. Dr. Tsui has expanded his research into the use of ultrasound in regional anesthesia, with particular relevance to peripheral nerve block performance. Dr. Tsui is also responsible for development of the E-Catheter catheter-over-needle kit for use during peripheral nerve blocks. The primary objective of his research is to transform regional anesthesia from an “art” into a reliable and reproducible “science” by further exploring the basic scientific and clinical aspects of electrophysiological signal monitoring and integrating this with the latest advances in ultrasound.
Dr. Tsui has received the Alberta Heritage Foundation for Medical Research (AHFMR) Clinical Scholar award and has previously received research awards and grants from the Canadian Institutes of Health Research (CIHR), Canadian Anesthesiologists’ Society, AHFMR, and University of Alberta. In 2015, a prestigious award, the CAS Research Recognition Award, was presented by the Canadian Anesthesiologists’ Society to Dr. Tsui "in recognition of significant research contributions to regional anesthesia, acute pain management and pediatric anesthesia in Canada and around the world".
Alexander Eckehart Urban
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics
Current Research and Scholarly Interests Complex behavioral and neuropsychiatric phenotypes often have a strong genetic component. This genetic component is often extremely complex and difficult to dissect. The current revolution in genome technology means that we can avail ourselves to tools that make it possible for the first time to begin understanding the complex genetic and epigenetic interactions at the basis of the human mind.
Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly Interests The long-term research goal of the Utz laboratory is to understand autoimmunity, autoantibodies, and how tolerance is broken and can be reestablished.
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics at the Lucile Salter Packard Children's Hospital
Bio Dr. Tulio A Valdez is a surgeon scientist born and raised in Colombia with a subspecialty interest in Pediatric Otolaryngology. He attended medical school at Universidad Javeriana in Bogota Colombia before undertaking his residency in Otolaryngology, Head and Neck Surgery in Boston. He completed his Pediatric Otolaryngology Fellowship at Texas Children’s Hospital (2007), Houston and obtained his Master’s in Clinical and Translational Research at the University of Connecticut.
Clinically, Dr. Valdez has an interest in airway surgery and swallowing disorders. He has a special interest in the management of sinus disease in cystic fibrosis. Dr. Valdez has co-authored one textbook and numerous book chapters and scientific manuscripts. Dr. Valdez continues his clinical research in these areas, particularly with a focus on aerodigestive disorders.
Scientifically, Dr. Valdez has developed various imaging methods to diagnose otitis media and cholesteatoma a middle ear condition that can lead to hearing loss. He was part of the Laser Biomedical Research Center at Massachusetts Institute of Technology. His research includes novel imaging modalities to better diagnose ear infections one of the most common pediatric problems. His research has now expanded to include better intraoperative imaging modalities in pediatric patients to improve surgical outcomes without the need for radiation exposure.
Dr. Valdez believes in the multi-disciplinary collaborations to tackle medical problems and has co-invented various medical devices and surgical simulation models.
Matt van de Rijn
Sabine Kohler, MD, Professor in Pathology
Current Research and Scholarly Interests Our research focuses on molecular analysis of human soft tissue tumors (sarcomas) with an emphasis on leiomyosarcoma and desmoid tumors. In addition we study the role of macrophages in range of malignant tumors.
Keith Van Haren, MD
Assistant Professor of Neurology and of Pediatrics at the Stanford University Medical Center
Current Research and Scholarly Interests Our research group is dedicated to innovating care for children with degenerative brain disorders. We are particularly focused on genetic and autoimmune disorders that cause damage to the myelin (the fatty insulation around the nerves) of the brain and spinal cord. X-linked adrenoleukodystrophy (genetic) and multiple sclerosis (autoimmune) are the prototypical examples of degenerative disorders of myelin and are the two disorders we study most intensively.
Krisa Van Meurs
Rosemarie Hess Professor in Neonatal and Developmental Medicine
Current Research and Scholarly Interests My research interests include persistent pulmonary hypertension of the newborn, hypoxic respiratory failure, inhaled nitric oxide therapy, ECMO, congenital diaphragmatic hernia, neonatal clinical trials, and the use of aEEG and NIRS to detect brain injury.
Shreyas Vasanawala, MD/PhD
Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly Interests Our group is focused on developing new fast and quantitative MRI techniques.
Professor of Developmental Biology and of Genetics
Current Research and Scholarly Interests Mechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.
Erin A. Vogel
Postdoctoral Research Fellow, SCRDP/ Heart Disease Prevention
Current Research and Scholarly Interests Adolescent e-cigarette use, smoking in the LGBTQ+ community, social media and well-being, multiple health risk behaviors, digital interventions for substance use
Instructor, Pediatrics - Infectious Diseases
Bio Dr. Vu is a pediatric infectious diseases specialist who is researching human responses to dengue virus and malaria infections. He performed his undergraduate studies at the University of California, San Diego, and obtained his medical doctorate at the University of Pennsylvania School of Medicine. He trained in general pediatrics at UCSF Benioff Children's Hospital Oakland, and in pediatric infectious diseases at Emory University School of Medicine. His present studies on pediatric dengue and malaria co-infection are supported by an NIAID Career Development Award (K23 AI127909) and a Instructor K Award Support Program Award from the Maternal & Child Health Research Institute and Department of Pediatrics.
Professor of Photon Science and of Structural Biology
Current Research and Scholarly Interests Ubiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators.
Rebecca D. Walker
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly Interests Interests include international development in emergency care, healthcare disparities, wilderness medicine, human rights, administration
Associate Professor of Pediatrics (Systems Medicine), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly Interests Systems biology for design of clinical solutions that detect and treat disease
Associate Professor of Surgery (Pediatric Surgery) at the Lucile Salter Packard Children's Hospital and, by courtesy, of Bioengineering
Current Research and Scholarly Interests Health Technology Innovation
Brian A. Wandell
Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and at the Graduate School of Education
Current Research and Scholarly Interests Models and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes.
C. Jason Wang, MD, PhD
Associate Professor of Pediatrics (General Pediatrics) at the Lucile Salter Packard Children's Hospital and of Medicine (Primary Care and Outcomes Research)
Bio Dr. Wang is the Director of Center for Policy, Outcomes and Prevention. Prior to coming to Stanford in 2011, he was a faculty member at Boston University Schools of Medicine and Public Health. His other professional experiences include working as a management consultant with McKinsey and Company and serving as the project manager for Taiwan's National Health Insurance Reform Task-force. His current interests include: 1) COVID-19 related policies; 2) developing tools for assessing and improving the value of healthcare; 3) facilitating the use of mobile technology in improving quality of care; 4) supporting competency-based medical education curriculum, and 5) engaging in healthcare delivery and payment reforms.
Postdoctoral Research Fellow, Radiation Biology
Bio Dr. Wang was trained at the Jacques Monod Institute and École Normale Supérieure in Paris, France under the mentorship of Dr. Terence Strick. and obtained his Ph.D. degree from the University of Paris in 2019. He dissected the molecular machinery of human and bacterial NHEJ, and interrogated the mechanism of SpCas9 tolerance to non-specific substrate using single-molecule nanomanipulation tools.
Jinglong’s research in the Frock Lab focuses on DSB-related chromosome topological changes and genomic interactions.
Kevin Wang, MD, PhD
Assistant Professor of Dermatology
Current Research and Scholarly Interests The Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation.
Clinical Associate Professor, Pediatrics
Current Research and Scholarly Interests Evaluation and management of the febrile young infant and infections in hospitalized children; promotion of appropriate antibiotic use.
Professor of Emergency Medicine and, by courtesy, of Pediatrics (Hospital Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests - Disparities in Emergency Medical Services for children.
- Efficacy of novel interventions for pediatric access to care.
- Teaching and supporting community-initiated interventions and programs internationally.
Paul J. Wang, MD
Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center and, by courtesy, of Bioengineering
Current Research and Scholarly Interests Dr. Wang's research centers on the development of innovative approaches to the treatment of arrhythmias, including more effective catheter ablation techniques, more reliable implantable devices, and less invasive treatments. Dr. Wang's clinical research interests include atrial fibrillation, ventricular tachycardia, syncope, and hypertrophic cardiomyopathy. Dr. Wang has active collaborations with Bioengineering, Mechanical Engineering, and Electrical Engineering Departments at Stanford.
Shan X. Wang
Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly Interests Shan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.