School of Medicine
Showing 1-20 of 67 Results
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Philip Beachy
The Ernest and Amelia Gallo Professor in the School of Medicine, Professor of Urology, of Developmental Biology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
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Gill Bejerano
Professor of Developmental Biology, of Computer Science, of Pediatrics (Genetics) and of Biomedical Data Science
Current Research and Scholarly Interests Dr. Bejerano, co-discoverer of ultraconserved elements, studies the Human Genome. His research focuses on genome sequence and function in both humans and related primate, mammalian and vertebrate species. He is deeply interested in mapping both coding and non-coding genome sequence variation to phenotype differences, and in extracting specific genetic insights from high throughput sequencing measurements, in the contexts of development and developmental abnormalities.
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Alistair Boettiger
Assistant Professor of Developmental Biology
Current Research and Scholarly Interests My lab focuses on investigating the role of three-dimensional genome organization in regulating gene expression and in shaping cell fate specification during development. We pursue this with advanced single-molecule imaging and transgenics.
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James K. Chen
Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry
Current Research and Scholarly Interests Our laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.
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Gerald Crabtree
Department of Pathology Professor in Experimental Pathology and Professor of Developmental Biology
Current Research and Scholarly Interests Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells.
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Margaret T. Fuller
Reed-Hodgson Professor in Human Biology and Professor of Genetics and of Obstetrics/Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly Interests Regulation of self-renewal, proliferation and differentiation in adult stem cell lineages. Developmental tumor suppressor mechanisms and regulation of the switch from proliferation to differentiation. Cell type specific transcription machinery and regulation of cell differentiation. Developmental regulation of cell cycle progression during male meiosis.
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Antonina Hafner
Postdoctoral Research Fellow, Developmental Biology
Bio I am a postdoctoral fellow in the lab of Alistair Boettiger in the Department of Developmental Biology. I have always been interested in understanding regulatory mechanisms that lead to tissue or cell type specific gene expression. During my PhD in the lab of Galit Lahav at Harvard Medical School, I studied how temporal dynamics of a tumor suppressor transcription factor, p53 regulate the dynamics of gene expression in response to DNA damage. In the Boettiger lab, I'm interested how specificity between enhancer-promoter interactions is achieved using super-resolution microscopy.
