School of Medicine
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Stephen A. Baccus
Associate Professor of Neurobiology
Current Research and Scholarly Interests We study how the neural circuitry of the vertebrate retina encodes visual information and performs computations. To control and measure the retinal circuit, we present visual images while performing simultaneous two-photon imaging and multielectrode recording. We perturb the circuit as it operates using simultaneous intracellular current injection and multielectrode recording, and use the resulting large data sets to construct models of retinal computation.
Shooter Family Professor
Current Research and Scholarly Interests The Clandinin lab focuses on understanding how neuronal circuits assemble and function to perform specific computations and guide behavior. Taking advantage of a rich armamentarium of genetic tools available in the fruit fly, combined with imaging, physiology and analytical techniques drawn from systems neuroscience, we examine a variety of visual circuits.
Assistant Professor of Neurobiology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly Interests Our research goal is to understand how dynamics in neuronal circuits relate and constrain the representation of information and computations upon it. We adopt three synergistic strategies: First, we analyze neural circuit population recordings to better understand the relation between neural dynamics and behavior, Second, we theoretically explore the types of dynamics that could be associated with particular network computations. Third, we analyze the structural properties of neural circuits.
Assistant Professor of Applied Physics and, by courtesy, of Neurobiology, of Electrical Engineering and of Computer Science
Current Research and Scholarly Interests Theoretical / computational neuroscience
Assistant Professor of Neurobiology
Current Research and Scholarly Interests My laboratory studies the cellular and molecular mechanisms underlying the organization of cortical circuits important for spatial navigation and memory. We are particularly focused on medial entorhinal cortex, where many neurons fire in spatially specific patterns and thus offer a measurable output for molecular manipulations. We combine electrophysiology, genetic approaches and behavioral paradigms to unravel the mechanisms and behavioral relevance of non-sensory cortical organization. Our first line of research is focused on determining the cellular and molecular components crucial to the neural representation of external space by functionally defined cell types in entorhinal cortex (grid, border and head direction cells). We plan to use specific targeting of ion channels, combined with in vivo tetrode recordings, to determine how channel dynamics influence the neural representation of space in the behaving animal. A second, parallel line of research, utilizes a combination of in vivo and in vitro methods to further parse out ionic expression patterns in entorhinal cortices and determine how gradients in ion channels develop. Ultimately, our work aims to understand the ontogenesis and relevance of medial entorhinal cortical topography in spatial memory and navigation.
Assistant Professor of Neurobiology
Current Research and Scholarly Interests Our laboratory studies the mechanisms by which highly complex behaviors are mediated at the neuronal level, mainly focusing on the example of dynamic social interactions and the neural circuits that drive them. From dyadic interactions to group dynamics and collective decision making, the lab seeks a mechanistic understanding for the fundamental building blocks of societies, such as cooperation, empathy, fairness and reciprocity.
Andrew D. Huberman, Ph.D.
Associate Professor of Neurobiology and of Ophthalmology
Current Research and Scholarly Interests 1) We study the mechanisms of neural degeneration and regeneration with the specific goal of developing treatments to prevent and reverse vision loss. (e.g., Laha and Huberman, Science, 2017; Lim et al., Nature Neuroscience, 2016).
2) We study the neural circuits that merge visual perceptions with internal states, to drive adaptive behavioral decisions. We are parsing the neural circuits for fear and anxiety, as well as for "courage" and positive states (e.g., Salay et al., Nature, 2018).
Adjunct Professor, Neurobiology
Current Research and Scholarly Interests Bioethics
Stem Cell Ethics
Eric I. Knudsen
Edward C. and Amy H. Sewall Professor in the School of Medicine, Emeritus
Current Research and Scholarly Interests Cellular mechanisms of spatial attention and learning, studied in the central nervous system in birds, using behavioral, systems, cellular and molecular techniques.
Associate Professor of Neurobiology, of Bioengineering and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Our lab applies biochemical and engineering principles to the development of protein-based tools for molecular imaging and gene therapy. Topics of investigation include fluorescent proteins structure and biophysics, fluorescent protein-based biosensors, spatiotemporal analysis of protein translation pathways, chemical control of protein translation, and light-responsive proteins.
Ann and Bill Swindells Professor in the School of Humanities and Sciences and Professor, by courtesy, of Neurobiology
Current Research and Scholarly Interests We are studying how neural circuits are assembled during development, and how they contribute to sensory perception. We are addressing these questions at different levels from molecular, cellular, circuit to animal behavior. We are primarily using Drosophila as a model organism for our studies. Most recently, we are also developing novel genetic tools in the mouse to extend our studies to the mammalian brain.
Uel Jackson McMahan
Professor of Neurobiology and of Structural Biology, Emeritus
Current Research and Scholarly Interests We are currently investigating mechanisms involved in synaptic transmission and synaptogenesis using electron microscope tomography in ways that provide in situ 3D structural information at macromolecular resolution.
Lloyd B. Minor, MD
The Carl and Elizabeth Naumann Professorship for the Dean of the School of Medicine, Professor of Otolaryngology—Head & Neck Surgery and, by courtesy, of Neurobiology and Bioengineering
Bio Lloyd B. Minor, MD, is a scientist, surgeon, and academic leader. He is the Carl and Elizabeth Naumann Dean of the Stanford University School of Medicine, a position he has held since December 2012.
As dean, Dr. Minor plays an integral role in setting strategy for the clinical enterprise of Stanford Medicine, an academic medical center that includes the Stanford University School of Medicine, Stanford Health Care, and Stanford Children’s Health and Lucile Packard Children’s Hospital Stanford. He also oversees the quality of Stanford Medicine’s physician practices and growing clinical networks.
With Dr. Minor’s leadership, Stanford Medicine has established a strategic vision to lead the biomedical revolution in Precision Health. The next generation of health care, Precision Health is focused on keeping people healthy and providing care that is tailored to individual variations. It’s predictive, proactive, preemptive, personalized, and patient-centered.
An advocate for innovation, Dr. Minor has provided significant support for fundamental science and for clinical and translational research at Stanford. Through bold initiatives in medical education and increased support for PhD students, Dr. Minor is committed to inspiring and training future leaders.
Among other accomplishments Dr. Minor has led the development and implementation of an innovative model for cancer research and patient care delivery at Stanford Medicine and has launched an initiative in biomedical data science to harness the power of big data and create a learning health care system. Committed to diversity, he has increased student financial aid and expanded faculty leadership opportunities.
Before coming to Stanford, Dr. Minor was provost and senior vice president for academic affairs of The Johns Hopkins University. During his time as provost, Dr. Minor launched many university-wide initiatives such as the Gateway Sciences Initiative to support pedagogical innovation, and the Doctor of Philosophy Board to promote excellence in PhD education. He worked with others around the university and health system to coordinate the Individualized Health Initiative, which aimed to use genetic information to transform health care.
Prior to his appointment as provost in 2009, Dr. Minor served as the Andelot Professor and director (chair) of the Department of Otolaryngology–Head and Neck Surgery in the Johns Hopkins University School of Medicine and otolaryngologist-in-chief of The Johns Hopkins Hospital. During his six-year tenure, he expanded annual research funding by more than half and increased clinical activity by more than 30 percent, while strengthening teaching efforts and student training.
With more than 140 published articles and chapters, Dr. Minor is an expert in balance and inner ear disorders. Through neurophysiological investigations of eye movements and neuronal pathways, his work has identified adaptive mechanisms responsible for compensation to vestibular injury in a model system for studies of motor learning (the vestibulo-ocular reflex). The synergies between this basic research and clinical studies have led to improved methods for the diagnosis and treatment of balance disorders. In recognition of his work in refining a treatment for Ménière’s disease, Dr. Minor received the Prosper Ménière Society’s gold medal in 2010.
In the medical community, Dr. Minor is perhaps best known for his discovery of superior canal dehiscence syndrome, a debilitating disorder characterized by sound- or pressure-induced dizziness. In 1998 Dr. Minor and colleagues published a description of the clinical manifestations of the syndrome and related its cause to an opening (dehiscence) in the bone covering the superior canal. He subsequently developed a surgical procedure that corrects the problem and alleviates symptoms.
In 2012, Dr. Minor was elected to the National Academy of Medicine, formerly the Institute of Medicine.
Professor of Neurobiology
Current Research and Scholarly Interests We study neural mechanisms of visual-motor integration and the neural basis of cognition (e.g. attention). We study the activity of single neurons in visual and motor structures within the brain, examine how perturbing that activity affects neurons in other brain structures, and also how it affects the perceptual and
Harman Family Provostial Professor, Vincent V. C. Woo Director of the Stanford Neurosciences Institute, and Professor of Neurobiology and, by courtesy, of Psychology
Current Research and Scholarly Interests Neural processes that mediate visual perception and visually-based decision making. Influence of reward history on decision making.
Jennifer L. Raymond
Professor of Neurobiology
Current Research and Scholarly Interests We study the neural mechanisms of learning, using a combination of behavioral, neurophysiological, and computational approaches. The model system we use is a form of cerebellum-dependent learning that regulates eye movements.
Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Neurobiology
Current Research and Scholarly Interests We study how our brains generate social interactions that differ between the sexes. Such gender differences in behavior are regulated by sex hormones, experience, and social cues. Accordingly, we are characterizing how these internal and external factors control gene expression and neuronal physiology in the two sexes to generate behavior. We are also interested in understanding how such sex differences in the healthy brain translate to sex differences in many neuro-psychiatric illnesses.
Sapp Family Provostial Professor, David Starr Jordan Director, Stanford Bio-X and Professor of Biology and of Neurobiology
Current Research and Scholarly Interests The goal of research in the Shatz Laboratory is to discover how brain circuits are tuned up by experience during critical periods of development both before and after birth by elucidating cellular and molecular mechanisms that transform early fetal and neonatal brain circuits into mature connections. To discover mechanistic underpinnings of circuit tuning, the lab has conducted functional screens for genes regulated by neural activity and studied their function for vision, learning and memory.
Hong Seh and Vivian W. M. Lim Professor in the School of Engineering and Professor, by courtesy, of Neurobiology and of Bioengineering
Bio Our group (Neural Prosthetic Systems Laboratory, NPSL; directed by Prof. Shenoy) conducts neuroscience, neuroengineering, and translational research to better understand how the brain controls movement, and to design medical systems to assist people with movement disabilities. Our neuroscience research investigates the neural basis of movement preparation and generation using a combination of electro-/opto-physiological, behavioral, computational and theoretical techniques. Our neuroengineering research investigates the design of high-performance and robust neural prostheses. Neural prostheses are also known as brain-computer interfaces (BCIs) and brain-machine interfaces (BMIs). These systems translate neural activity from the brain into control signals for prosthetic devices, which can assist people with paralysis by restoring lost motor functions. Our translational research, including an FDA pilot clinical trial termed BrainGate2, are conducted as part of the our Neural Prosthetic Translational Laboratory (NPTL; co-directed by Profs. Shenoy & Henderson).