School of Medicine
Showing 1-10 of 21 Results
The Ernest and Amelia Gallo Professor in the School of Medicine, Professor of Developmental Biology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
Professor of Biology
Current Research and Scholarly Interests We use genetic, genomic and cell biological approaches to study cell fate acquisition, focusing on cases where cell fate is correlated with asymmetric cell division.
Helen M. Blau
The Donald E. and Delia B. Baxter Foundation Professor and Director, Baxter Laboratory for Stem Cell Biology
Current Research and Scholarly Interests Prof. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.
Michael F. Clarke, M.D.
Karel H. and Avice N. Beekhuis Professor in Cancer Biology
Current Research and Scholarly Interests Dr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and diseases such as cancer and hereditary diseases; and ii) the identification and characterization of cancer stem cells. His laboratory is investigating how perturbations of stem cell regulatory machinery contributes to human disease. In particular, the laboratory is investigating epigenetic regulators of self renewal, the process by which stem cells regenerate themselves.
Associate Professor of Medicine (Pulmonary and Critical Care)
Current Research and Scholarly Interests We investigate the cellular and molecular events that regulate proper development of the lungs, including how the gas exchange region is maintained and renewed throughout life. We apply this knowledge to dissect how dysregulation of these normal processes can cause or contribute to specific lung diseases like pulmonary fibrosis, emphysema, and lung cancer, and we are interested in uncovering how lung stem cells are regulated in the hopes of harnessing them as a regenerative therapy for patients.
Maximilian Diehn, MD, PhD
Associate Professor of Radiation Oncology (Radiation Therapy)
Current Research and Scholarly Interests My laboratory focuses on two main areas: 1) cancer stem cell biology and 2) novel biomarkers for identifying the presence of malignant cells (diagnostic), predicting outcome (prognostic), and predicting response to therapy (predictive). Areas of study include cancers of the lung, breast, and gastrointestinal system. Clinically I specialize in the treatment of lung cancer and applications of stereotactic ablative radiotherapy and perform both prospective and retrospective clinical studies.
Brian Feldman, MD, PhD
Assistant Professor of Pediatrics (Endocrinology)
Current Research and Scholarly Interests The overall goal of our research is to understand on both a molecular and systemic level how hormones regulate stem cell fate decisions and the role these pathways play in both physiology and disease. We use molecular biology and in vivo models to elucidate mechanisms of regulating cell fate determination by the endocrine system. Understanding these processes has profound and broad implications for both science and health.
Margaret T. Fuller
Reed-Hodgson Professor in Human Biology and Professor of Genetics and of Obstetrics/Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly Interests Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.
Seung K. Kim M.D., Ph.D.
Professor of Developmental Biology and, by courtesy, of Medicine (Endocrinology)
Current Research and Scholarly Interests We study the genetics of pancreatic islet cell differentiation using molecular, embryologic and genetic methods in several model systems, including mice, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. Our knowledge of genetic and cellular pathways governing islet formation has allowed us to use stem cell lines to produce islet replacements in vitro.
Kyle M. Loh
Assistant Professor of Developmental Biology (Stem Cell)
Current Research and Scholarly Interests We have developed a strategy to generate fairly pure populations of various human tissue progenitors in a dish from embryonic stem cells (ESCs). We have delineated the sequential lineage steps through which ESCs diversify into various tissues, and in so doing, developed methods to exclusively induce certain fates at the expense of others. The resultant pure populations of tissue progenitors are the fundamental building blocks for regenerative medicine.