School of Medicine
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Associate Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly Interests My laboratory studies the strategies pathogens utilize to colonize and subvert the epithelial barrier. We have focused on the epithelial junctions as a target for bacterial pathogens, since the cell-cell junctions serve as both a barrier to infection and also a major control site for epithelial function. In particular, we are interested in how the gastric pathogen Helicobater pylori may cause cancer by interfering with cell signaling at the epithelial junctions. We are also studying how various bacteria cross and invade the epithelium. For example, we recently found that Listeria monocytogenes targets a specialized subset of cell-cell junctions at the tip of the intestinal villi to find its receptor for invasion. We are interested in determining whether this mode of gastrointestinal invasion of the epithelium is also used by other gastrointestinal pathogens.
Ann M. Arvin
Vice Provost and Dean of Research, Lucile Salter Packard Professor of Pediatrics and Professor of Microbiology and Immunology
Current Research and Scholarly Interests Our laboratory investigates the pathogenesis of varicella zoster virus (VZV) infection, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in humans and in Scid-hu mouse models of VZV cell tropisms in vivo, and the immunobiology of VZV infections.
Sharon F. Chen
Instructor, Pediatrics - Infectious Diseases
Current Research and Scholarly Interests My research interest is focused on Herpes virus pathogenesis and the host immune response to these viral infections. To characterize these interactions, we use flow-cytometry based immunology assays, culture-based assays, molecular techniques and tissue histology. My current study investigates anti-viral immunity to CMV in lung transplant patients to characterize the kinetics of CMV-specific T-cell reconstitution and to test its ability to predict CMV infection and allograft rejection.
Despina Contopoulos-Ioannidis, MD
Clinical Associate Professor, Pediatrics - Infectious Diseases
Current Research and Scholarly Interests Evidence based medicine Systematic reviews Meta-analyses
Comparative safety research
Chronic Antibiotic Use and Weight Gain
Family outbreaks and Epidemiology of acute toxoplasmosis in US
Congenital toxoplasmosis: Improving laboratory dx
Trends in intussusception in the US (association with pediatric vaccines)
Empirical appraisal of CEA for pediatric vaccines (with and without inlcusion of herd immunity
Cornelia L. Dekker, M.D.
Professor (Research) of Pediatrics (Infectious Diseases)
Current Research and Scholarly Interests The Stanford-LPCH Vaccine Program provides an infrastructure for conducting clinical studies of vaccines in children and adults. We conduct immunology studies of seasonal influenza vaccines in twins, in a longitudinal cohort of young and elderly adults and studies of vaccine candidates for NIH and industry. Additionally, we were a CDC Clinical Immunization Safety Assessment site for 10 years working on safety issues concerning licensed vaccines.
Assistant Professor of Pediatrics (Infectious Diseases) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests The focus of my laboratory is the immune response to viral vaccines evaluating the ontogeny of responses in infants and limitations in immunocompromised hosts. We have studied responses to an early two-dose measles immunization, one versus 2 doses of varicella immunization, and polio vaccine in preterm versus term infants. Other active areas of research include measles and varicella immunity in HIV infected individuals, and transplant recipients.