School of Medicine


Showing 1-20 of 195 Results

  • John Wachtel

    John Wachtel

    Clinical Professor, Obstetrics & Gynecology - General

    Bio Dr. Wachtel has been practicing general obstetrics and gynecology for 38 years and has personally delivered over 6,000 babies. He continues to have an active practice in general ob/gyn, serving as a Clinical Professor. He is a nationally recognized expert in patient safety, peer review and data driven quality improvement and has served numerous roles in the field and lectured nationally and internationally. Dr. Wachtel is the Assistant Secretary for the American College of Obstetricians and Gynecologists (ACOG) and currently serves on the ACOG National Executive Board and Executive Committee. He is the immediate Past Chair for ACOG District IX (the state of California) and also previously served for three years on the ACOG national Executive Board. He also serves on the Executive Committee for the California Maternal Quality Care Collaborative and is an Expert Medical Reviewer for the Medical Board of California.

  • Alexei Wagner

    Alexei Wagner

    Clinical Assistant Professor, Emergency Medicine

    Current Research and Scholarly Interests Applications of big data and machine learning in medicine
    Developing mobile health applications
    Analyzing streaming health data
    Applications of video laryngoscopy in prehospital settings
    Internet health search

  • Todd Wagner

    Todd Wagner

    Associate Professor (Research) of Surgery (Health Services Research Unit)

    Bio Todd Wagner is an Associate Professor in the Department of Surgery at Stanford University. He studies health information, efficiency and value, and health care access. He is particularly interested in developing learning health care systems that provide high value care. In addition to his role at Stanford, he Directs the Health Economics Resource Center and is the Associate Director for the Center for Innovation to Implementation, both at the Palo Alto VA. He also co-directs the VA/NCI Big Data Fellowship.

  • Soichi Wakatsuki

    Soichi Wakatsuki

    Professor of Photon Science and of Structural Biology

    Current Research and Scholarly Interests Ubiquitin signaling: structure, function, and therapeutics
    Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
    We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.

    Protein self-assembly processes and applications.
    The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.

    Multiscale imaging and technology developments.
    Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators.

  • Heather Wakelee

    Heather Wakelee

    Professor of Medicine (Oncology) at the Stanford University Medical Center

    Current Research and Scholarly Interests Dr. Wakelee's research is focused on clinical trials and translational efforts in patients with lung cancer and other thoracic malignancies such as thymoma and thymic carcinoma. Other interests include translation projects in thoracic malignancies and collaborations with population scientists regarding lung cancer questions.

  • Rebecca D. Walker

    Rebecca D. Walker

    Clinical Associate Professor, Emergency Medicine

    Current Research and Scholarly Interests Interests include international development in emergency care, healthcare disparities, wilderness medicine, human rights, administration

  • Dennis Wall

    Dennis Wall

    Associate Professor of Pediatrics (Systems Medicine), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences

    Current Research and Scholarly Interests Systems biology for design of clinical solutions that detect and treat disease

  • Jessica Walter

    Jessica Walter

    Clinical Assistant Professor, Neurology & Neurological Sciences

    Bio Dr. Walter received her MD from Georgetown University in Washington, DC. She stayed at Georgetown for her internship in Internal Medicine and then moved to New York City to complete her residency in Neurology at the Icahn School of Medicine at Mount Sinai. She went on to pursue a Clinical Neurophysiology Fellowship at Rush University in Chicago, IL, training in both EEG and EMG. Due to her particular interest in Epilepsy she went on to become the first Epilepsy Fellow at Rush University. Dr. Walter provides clinical care to general neurology patients as well as patients with epilepsy and enjoys teaching residents and medical students. She also has a particular interest in dietary treatments for epilepsy and clinical research.

  • Brian A. Wandell

    Brian A. Wandell

    Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and at the Graduate School of Education

    Current Research and Scholarly Interests Models and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes.

  • Tom Wandless

    Tom Wandless

    Professor of Chemical and Systems Biology and, by courtesy, of Chemistry

    Current Research and Scholarly Interests We employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. We invent tools for biology and we are motivated by approaches that enable new experiments with unprecedented control. These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. Protein quality control is a particular interest at present.

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