School of Medicine
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John A. and Cynthia Fry Gunn Professor and Professor of Neurology and of Neurosurgery
Current Research and Scholarly Interests Neuron death, stress, gene therapy
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine, of Neurosurgery and, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly Interests Our laboratory investigates the neural mechanisms that underlie the sensory and affective dimensions of pain experience. We also study how opioids interfere with these mechanisms to provide pain relief, but also deleterious effects such as tolerance, addiction and respiratory depression. Our goal is to better understand the neural basis of pain experience and opioid effects to discover novel treatments that block pain more efficiently and safely than current opioid drugs.
Neil Schwartz, MD, PhD
Clinical Professor, Neurology & Neurological Sciences
Current Research and Scholarly Interests My clinical interests involve inpatient and outpatient care of patients with neurovascular diseases, mostly ischemic and hemorrhagic stroke. I have a particular interest in cervical artery dissection, non-atherosclerotic vasculopathies, and stroke in the young.
Professor (Research) of Neurosurgery and, by courtesy, of Neurology
Current Research and Scholarly Interests The ultimate goal of the Shamloo laboratory is to rapidly advance our understanding of brain function at the molecular, cellular, circuit and behavioral levels, and to elucidate the pathological process underlying malfunction of the nervous system following injury and neurologic disorders such as stroke, Alzheimer's disease, Parkinson’s disease, and autism. We have been focusing on the noradrenergic system and approaches leading to restoration of brain adrenergic signaling in these disorders.
Lawrence Shuer, MD
Professor of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests I have clinical research interests in the surgical treatment of epilepsy. I am also interested in new developments in the treatment of craniosynostosis a congenital abnormality of infant's skulls
Professor of Neurosurgery, Emeritus
Current Research and Scholarly Interests Age-related changes in the blood-brain barrier (BBB)and on CSF dynsmics decrease the clearance of toxic metabolites, such as amyloid beta peptides (A-betas), from the brain. I am studing the effects of aging and hydrocephalus on the BBB receptors that transport A-betas and on the formation and bulk flow of CSF.
Harminder Singh, M.D.
Clinical Associate Professor, Neurosurgery
Current Research and Scholarly Interests Minimally Invasive Cranial and Spinal Surgery, Endoscopic Keyhole Surgery
Associate Professor of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests My research focuses on screening strategies to identify and characterize cancer stem cells (CSCs) in human gliomas. We are pursuing this in several ways: 1) a novel colony-forming antibody live cell array to identify distinct CSC surface phenotypes, 2) RNAi screens to identify kinases critical for CSC tumorigenicity, 3) high throughput small molecule and chemical screens to identify compounds that selectively kill or target CSCs, and 4) identifying CSCs using the tumor specific EGFRvIII
James R. Doty Professor of Neurosurgery and Neurosciences
Bio Ivan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty.