School of Medicine

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  • Adrish Sen

    Adrish Sen

    Sr Res Scientist-Basic Ls, Medicine - Med/Gastroenterology and Hepatology

    Bio My research focuses on Rotavirus (RV) - the causative agent of acute infantile diarrhea, that is responsible for more than 200,000 deaths annually. My earlier work explored RV molecular epidemiology and virion assembly mechanisms. This led to the identification of novel group B rotaviruses, which cause adult diarrhea in humans and exhibit pandemic potential. I subsequently characterized molecular mechanisms by which rotaviruses assemble in infected cells - specifically how a viral non-structural protein, NSP5, forms higher-order assembly scaffolds by a calcium-triggered reversible molecular switch.
    Since moving to Stanford University, my research in Dr. Harry Greenberg’s laboratory has focused on understanding the role that innate immunity plays in determining rotavirus species barriers, pathogenicity, and shaping the overall immune response to natural and vaccine-related RV infections. Our work defined the pathways leading to RV recognition by the host interferon response and uncovered viral strategies to regulate this process. Single-cell studies have revealed that RV degrades all three major IFN type receptors in infected cells, and remarkably, also confers pleiotropic IFN resistance to RV-bystander cells (which express normal levels of IFN receptors). These viral regulatory mechanisms possibly underlie the unexpected ability of RV infection to prevent lethal endotoxemia, which we reported recently. I have a strong interest in dissecting host antiviral responses to pathogenic and attenuated viruses at the population and single-cell levels using microfluidics qRT-PCR, multi-color cytometry, and novel mass cytometry techniques. In other ongoing research, I am examining differences in cell type-specific innate responses to pathogenic and attenuated influenza viruses in the human nasal mucosa (primarily using clinical and volunteer nasal swab specimens).

  • Sundeep Singh

    Sundeep Singh

    Clinical Assistant Professor, Medicine - Gastroenterology & Hepatology

    Bio After living and training throughout the country, I am excited to be part of the Stanford team. As a result of both my personal experiences and training, I am passionate about ensuring that patients receive appropriate diagnostic testing and treatment options in order to improve people's quality of life. In collaboration with my amazing colleagues, I am confident in the high quality and easily accessible care we are able to provide to patients across northern California.

    While my interest is most in inflammatory bowel disease, I am also interested in the interaction between mental health, incentives, and emerging therapies in gastroenterology.

  • Sidhartha Sinha

    Sidhartha Sinha

    Assistant Professor of Medicine (Gastroenterology and Hepatology) at the Stanford University Medical Center

    Current Research and Scholarly Interests There are two primary and overlapping emphases of my research, both of which are driven and united by needs-based innovation and translational potential:

    (1) Understanding the microenvironment of the inflamed versus normal gut in order to identify better therapeutic targets for people with immune-¬mediated GI disorders. Here, our investigations include understanding the influence and interactions of pharmacologic and dietary interventions on gut microbiome/metabolomic changes and the host immune response. In the context of providing patients with new understanding and solutions for their disease, I have led and advised on the design of both pilot and large clinical trials (including new FDA approved therapies) for anti-inflammatory therapies;

    (2) Applying novel approaches and technologies (including natural language processing, computer vision, and reinforcement learning) to identify and address unmet clinical needs. In this area we have ongoing and published efforts in my lab to validate and develop solutions to pressing clinical needs. We have developed/led new drug delivery technologies with a multidisciplinary team that have shown strong potential in ongoing human IBD clinical trials. My lab has utilized both supervised and unsupervised approaches to analyze social media discourse and unstructured data sets for identifying patient needs that are rarely addressed in clinical settings. We have gained insights into patient perceptions around preventative health interventions, such as health screening and diet, including the dearth of evidence-based dietary recommendations to treat IBD (despite strong patient desire for solutions in this domain).