School of Medicine
Showing 1-10 of 25 Results
David T. Paik
Postdoctoral Research Fellow, Cardiovascular Institute
Bio Dr. David Paik is a postdoctoral fellow working with Dr. Joseph Wu at Stanford Cardiovascular Institute. At Stanford, his focus is to utilize single-cell RNA-sequencing technology to elucidate patient-specific mechanisms of various cardiovascular diseases, characterize embryonic heart development, and optimize differentiation of iPSCs to subtypes of cardiovascular cells. Dr. Paik received his BA in Biochemistry and Molecular Biology at Boston University (2010) and PhD in Cell and Developmental Biology at Vanderbilt University (2015). At Vanderbilt, Dr. Paik was trained by Dr. Antonis Hatzopoulos to investigate the endogenous cardiac repair mechanisms in the adult heart following ischemic injury such as myocardial infarction. In particular, Dr. Paik focused on the role of Wnt signaling pathway on coronary vessel formation and plasticity of cardiac endothelial cells during cardiac tissue repair. During his PhD training, Dr. Paik completed HHMI/VUMC Certificate Program in Molecular Medicine, where he was supervised by his clinical mentor Dr. Douglas Sawyer to interact with congestive heart failure patients and to bridge clinical sciences with basic and translational cardiovascular research.
Associate Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences) at the Stanford University Medical Center
Current Research and Scholarly Interests Research focused on developing interventions for management of side effects of cancer treatments (e.g., sleep disturbance, fatigue, depression, anxiety).
Professor of Neurosurgery
Current Research and Scholarly Interests Members of the Palmer Lab study the biology of neural stem cells in brain development and in the adult. Our primary goal is to understand how genes and environment synergize in influencing stem cell behavior during development and how mild genetic or environmental risk factors for disease may synergize in their detrimental effects on brain development or in the risk of neuronal loss in age-related degenerative disease.
Alan C. Pao
Assistant Professor of Medicine (Nephrology) and, by courtesy, of Urology at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly Interests We are interested in how the kidneys control salt, water, and electrolyte homeostasis in the body. We use cultured kidney cells, transgenic mice, and human samples to study hormonal and signal transduction pathways that control epithelial ion transport. Clinical implications of our work include a better understanding of the pathogenesis of salt-sensitive hypertension and kidney stone formation and growth.
Karen J. Parker, PhD
Associate Professor (Research) of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
Current Research and Scholarly Interests The Parker Lab conducts research on the biology of social functioning in monkeys, typically developing humans, and patients with social impairments.
George DeForest Barnett Professor in Medicine and Professor of Health Research and Policy (Epidemiology)
Current Research and Scholarly Interests I am an infectious diseases epidemiologist who has done large field studies in both the US and developing countries. We research the long-term consequences of chronic interactions between the human host and the microbial world. My lab has done fundamental work establishing the role of H. pylori in causing disease and understanding its epidemiology. Currently, our research dissects how and when children first encounter microbes and the long term effects of these exposures on health.
Clinical Associate Professor, Neurology & Neurological Sciences
Current Research and Scholarly Interests My research interests involve the epidemiology, treatment and diagnosis of pediatric and young adult brain tumors. I am also interested in long-term neurologic effects and designing clinical trials to treat brain and spinal cord tumors.
Josef Parvizi, MD, PhD
Professor of Neurology at the Stanford University Medical Center
Bio Dr Parvizi completed his medical internship at Mayo Clinic and Neurology Residency at BIDMC Harvard Medical School before joining the UCLA for fellowship training in clinical neurophysiology and epilepsy. He has worked at Stanford University Medical Center since 2007 and specializes in treating patients with uncontrollable seizures. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience whose research activities have been supported by National Institute of Health, National Science Foundation, and private foundations. To find out more about Dr Parvizi's scholarly activities please visit http://med.stanford.edu/parvizi-lab.html.
Anca M. Pasca, MD
Assistant Professor of Pediatrics at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests The research focus of the lab is to understand molecular mechanisms underlying neurodevelopmental disorders associated with premature birth, neonatal and fetal brain injury with the long-term goal of translating the lab’s findings into therapeutics. The research team employs a multidisciplinary approach involving genetics, molecular and developmental neurobiology, animal models and neural cells differentiated from patient-derived induced pluripotent stem (iPS) cells. In particular, the lab is using a powerful 3D human brain-region specific organoid system developed at Stanford (Nature Methods, 2015; Nature Protocols, 2018) to ask questions about brain injury during development.
Sergiu P. Pasca
Assistant Professor of Psychiatry and Behavioral Sciences (Sleep Disorder/Sleep Center)
Current Research and Scholarly Interests A critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
Our lab is using pluripotent stem cells derived non-invasively from human individuals to generate in a dish specific regions of the human brain in a functional 3D preparation we have developed. We are using months-to-years long ‘brain-a-dish’ cultures (also known as brain region-specific organoids or spheroids) to understand how neurons find their final position in the brain and how they mature functionally. To investigate how different brain regions talk to each-other in normal and diseased states, we introduced a new approach for in vitro assembly of neural circuits, also known as assembloids.
We employ state-of-the-art stem cell biology, genome engineering, imaging and neuroscience approaches to identify the dynamical processes that go awry in neural cells derived from patients with neuropsychiatric disorders, such as autism or schizophrenia, and what should be therapeutically targeted in these conditions.