School of Medicine
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Postdoctoral Research Fellow, Cardiovascular Medicine
Bio I am an Australian physician (MD, PhD) currently working as a Post-Doctoral Research Fellow at Stanford University. I am jointly supervised by Professor Euan Ashley and Professor John Ioannidis and am an active member of both labs: the Ashley Lab and Meta-Research Innovation Center at Stanford (METRICS, Ioannidis).
My fellowship concerns the diagnosis and risk prediction of cardiovascular disease. I employ a variety of statistical methods to assess new diagnostic technologies, such as smart phones and smart wearables, and my work also extends to computational cardiac genetics. The data sources I utilize to conduct my research are numerous, but include large datasets such as the UK Biobank, as well as publicly available dataset (meta-analysis and meta-research). I have also previously used large electronic health records (>250 million EHRs).
Aside from my own research prioritizes (above), I also work on studies conducted collaboratively within the Ashley Lab, the Division of Cardiovascular Medicine and METRICS. These studies broadly include digital health randomized controlled trials (RCTs) and meta-research (including statistical methods such as meta-analysis, meta-regression etc).
I previously completed a DPhil (PhD) in clinical epidemiology at the University of Oxford as a Clarendon Scholar. The title of My DPhil thesis was: “Biostatistical and meta-research approaches to assess diagnostic tests”. My published research is available at my google scholar page (https://scholar.google.co.uk/citations?user=n5l7tL8AAAAJ&hl=en) and some of my code is publicly available at my GitHub (https://github.com/jackosullivanoxford).
Beyond academic institutions, I also consult to the World Health Organization (WHO); including on WHO guidelines, where I am currently the methodological chair for a WHO guideline concerning the early(ier) detection of disease in adults. I also work as an associate editor at one of the BMJ sub-journals: BMJ EBM. During my DPhil I worked clinically at Oxford University Hospitals (John Radcliffe Hospital) and intend to return to clinical practice as a Physician-Scientist at Stanford upon the completion of my research Fellowship.
You can follow me on twitter (https://twitter.com/DrJackOSullivan): where you will find me tweeting about statistics, surfing, cardiology, medicine, epidemiology, health policy, and, occasionally, politics.
Postdoctoral Research Fellow, Pathology
Current Research and Scholarly Interests Currently working on unraveling the mechanisms of Alzheimer's disease progression utilizing mass cytometry (CyTOF) and high-dimensional imaging (multiplxed ion beam imaging - MIBI).
Previously worked on evaluating the role of immune cells in allergic pathogenesis (IgE+ B cells, regulatory B cells or Bregs, basophils, type 2 innate lymphoid cells, eosinophils).
Collaborated on research projects with a few research groups, which include:
- The Hospital for Sick Children, Division of Pediatric Emergency Medicine and Pediatric Research Academic Initiative in SickKids Emergency (PRAISE) Program
- McMaster Children's Hospital, Division of Urology and the Clinical Urology Research Enterprise (CURE) Program
- St. Joseph's Healthcare Center Hamilton, Division of Otolaryngology and Head and Neck Surgery
Research interests include:
- The immunobiology and pathophysiology of allergic diseases (allergic asthma, allergic rhinitis)
- The role and function of regulatory B cells in disease (autoimmunity, inflammation, cancer)
- The role of immune cells (B cells, T cells, eosinophils, basophils) in the pathogenesis of disease
- Single cell analyses and 'omics' technologies including: RNAseq, CyTOF, flow and imaging cytometry
- Translational immunology, clinical drug development and clinical trials, "big data", and machine learning
- Effectiveness of active learning in undergraduate and graduate level education