School of Medicine

Showing 321-330 of 332 Results

  • Gerald Fuller

    Gerald Fuller

    Fletcher Jones II Professor in the School of Engineering

    Bio The processing of complex liquids (polymers, suspensions, emulsions, biological fluids) alters their microstructure through orientation and deformation of their constitutive elements. In the case of polymeric liquids, it is of interest to obtain in situ measurements of segmental orientation and optical methods have proven to be an excellent means of acquiring this information. Research in our laboratory has resulted in a number of techniques in optical rheometry such as high-speed polarimetry (birefringence and dichroism) and various microscopy methods (fluorescence, phase contrast, and atomic force microscopy).

    The microstructure of polymeric and other complex materials also cause them to have interesting physical properties and respond to different flow conditions in unusual manners. In our laboratory, we are equipped with instruments that are able to characterize these materials such as shear rheometer, capillary break up extensional rheometer, and 2D extensional rheometer. Then, the response of these materials to different flow conditions can be visualized and analyzed in detail using high speed imaging devices at up to 2,000 frames per second.

    There are numerous processes encountered in nature and industry where the deformation of fluid-fluid interfaces is of central importance. Examples from nature include deformation of the red blood cell in small capillaries, cell division and structure and composition of the tear film. Industrial applications include the processing of emulsions and foams, and the atomization of droplets in ink-jet printing. In our laboratory, fundamental research is in progress to understand the orientation and deformation of monolayers at the molecular level. These experiments employ state of the art optical methods such as polarization modulated dichroism, fluorescence microscopy, and Brewster angle microscopy to obtain in situ measurements of polymer films and small molecule amphiphile monolayers subject to flow. Langmuir troughs are used as the experimental platform so that the thermodynamic state of the monolayers can be systematically controlled. For the first time, well characterized, homogeneous surface flows have been developed, and real time measurements of molecular and microdomain orientation have been obtained. These microstructural experiments are complemented by measurements of the macroscopic, mechanical properties of the films.

  • Margaret T. Fuller

    Margaret T. Fuller

    Reed-Hodgson Professor in Human Biology and Professor of Genetics and of Obstetrics/Gynecology (Reproductive and Stem Cell Biology)

    Current Research and Scholarly Interests Regulation of self-renewal, proliferation and differentiation in adult stem cell lineages. Developmental tumor suppressor mechanisms and regulation of the switch from proliferation to differentiation. Cell type specific transcription machinery and regulation of cell differentiation. Developmental regulation of cell cycle progression during male meiosis.

  • Lawrence Fung

    Lawrence Fung

    Clinical Assistant Professor, Psychiatry and Behavioral Sciences - Child and Adolescent Psychiatry

    Current Research and Scholarly Interests Dr. Fung is a child & adolescent psychiatrist with specialized clinical training in autism spectrum disorder (ASD) and advanced research training in chemical engineering, neuropsychopharmacology, and neuroimaging. He has extensive work experience in pharmaceutical research and development, including the discovery and development of a GABA(A) receptor agonist for the treatment of insomnia and anxiety.

    Dr. Fung serves as a co-investigator and co-protocol director of a current randomized controlled trial of pregnenolone in children and adolescents with ASD. Dr. Fung is interested in elucidating the mechanisms of action of pregnenolone and its related neurosteroids in the treatment of individuals with ASD.

    In addition to pharmacologic treatment studies in ASD and other developmental disorders, he is also performing multimodal neuroimaging studies in these disorders. Dr. Fung employs state-of-the-art multimodal neuroimaging tools to study GABA neurophysiology in individuals with ASD, fragile X syndrome (FXS) and intellectual disability. He is the Principal Investigator of NIH-funded "GABAergic Neurophysiology in Autism Spectrum Disorder". He serves as a Co-investigator of "Cross-Species Multi-Modal Neuroimaging to Investigate GABA Physiology in Fragile X Syndrome".

    His overarching goal is to dissect the neurobiology of ASD using a combination of bioanalytical, immunochemical, and multimodal imaging techniques to identify biomarkers based on specific molecular mechanisms that will inform targeted treatments for ASD.

  • David Furman

    David Furman

    Visiting Associate Professor, Institute for Immunity, Transplantation and Infection

    Bio David Furman obtained his Doctoral degree in immunology (summa cum laude) from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his Postdoc at the laboratory of Professor Mark M Davis, (Stanford) he conducted cutting-edge research in Data Science and Systems Immunology to answer scientific questions with strong potential for translational medicine, including the effect of aging, gender and common viral infections in immune system functioning. Dr. Furman’s work focuses in Data Science applied to inflammation and aging. Before joining as an Adjunct Investigator at the National Scientific and Research Council (CONICET), Buenos Aires, Argentina, Dr Furman was a Senior Scientist at the Institute for Immunity, Transplantation and Infection (ITI), Stanford, and his work involved the use of high-bandwidth/high-throughput technologies and Machine Learning tools to better define the human immune system. Dr David Furman is a Visiting Associate Professor at the same institute.