School of Medicine
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George D. Smith Professor in Molecular and Genetic Medicine and Professor of Pathology and of Genetics
Current Research and Scholarly Interests We study natural cellular mechanisms for adapting to genetic change. These include systems activated during normal development and those for detecting and responding to foreign or unwanted genetic activity. Underlying these studies are questions of how a cells can distinguish information as "self" versus "nonself" or "wanted" versus "unwanted".
George A. Fisher Jr.
Colleen Haas Chair in the School of Medicine
Current Research and Scholarly Interests Clinical expertise in GI cancers with research which emphasizes Phase I and II clinical trials of novel therapies but also includes translational studies including biomarkers, molecular imaging, tumor immunology and development of immunotherapeutic trials.
Paul Graham Fisher, MD
Bing Director of the Program in Human Biology, Beirne Family Professor of Pediatric Neuro-Oncology, Professor of Pediatrics and, by courtesy, of Neurosurgery and of Health Research and Policy (Epidemiology) at SUMC
Current Research and Scholarly Interests Clinical neuro-oncology: My research explores the epidemiology, natural history, and disease patterns of brain tumors in childhood, as well as prospective clinical trials for treating these neoplasms. Research interests also include neurologic effects of cancer and its therapies, and childhood headaches.
Professor of Medicine (Oncology) and of Genetics and, by courtesy, of Pediatrics
Current Research and Scholarly Interests Mammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNAdamage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer.
Associate Professor of Biology
Current Research and Scholarly Interests We study the regulation and evolution of gene expression using a combination of experimental and computational approaches.
Our work brings together quantitative genetics, genomics, epigenetics, and evolutionary biology to achieve a deeper understanding of how genetic variation within and between species affects genome-wide gene expression and ultimately shapes the phenotypic diversity of life.
Assistant Professor of Radiation Oncology (Radiation and Cancer Biology)
Current Research and Scholarly Interests Mechanisms of DNA double-strand break repair and chromosomal translocations
Donald Kennedy Chair in the School of Humanities and Sciences and Professor of Genetics
Current Research and Scholarly Interests The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
Margaret T. Fuller
Reed-Hodgson Professor in Human Biology and Professor of Genetics and of Obstetrics/Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly Interests Regulation of self-renewal, proliferation and differentiation in adult stem cell lineages. Developmental tumor suppressor mechanisms and regulation of the switch from proliferation to differentiation. Cell type specific transcription machinery and regulation of cell differentiation. Developmental regulation of cell cycle progression during male meiosis.