School of Medicine
Showing 21-30 of 44 Results
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Lawrence Chu, MD, MS
Professor of Anesthesiology, Perioperative and Pain Medicine at the Stanford University Medical Center
Current Research and Scholarly Interests I have two lines of research, one involving educational informatics and use of technology in postgraduate medical education and another involving NIH-funded work in patient-oriented clinical research regarding opioid use and physiologic responses associated with acute and chronic exposure in humans.
For a full description of my educational informatics work, please see my website aim.stanford.edu.
My clinical research focuses on the study opiate-induced hyperalgesia in patients suffering from chronic pain.
I am currently conducting an NIH-funded five year double-blinded randomized controlled clinical study (NIGMS award 1K23GM071400-01) that prospectively examines the following hypotheses: 1) pain patients on chronic opioid therapy develop dose-dependent tolerance and/or hyperalgesia to these medications over time, 2) opiate-induced tolerance and hyperalgesia develop differently with respect to various types of pain, 3) opioid-induced hyperalgesia occurs independently of withdrawal phenomena, and 4) opiate-induced tolerance and hyperalgesia develop differently based on gender and/or ethnicity.
The study is the first quantitative and prospective examination of tolerance and hyperalgesia in pain patients and may have important implications for the rational use of opioids in the treatment of chronic pain. -
David Clark
Professor of Anesthesiology, Perioperative and Pain Medicine at the Palo Alto Veterans Affairs Health Care System
Bio After completion of training I came to Stanford University in 1998. Since that time I have been involved in a number of clinical and research activities. I oversee the Pain Service at the Palo Alto VA hospital where I am involved in the care of patients with both acute and chronic pain. I am active both in the clinic and on a number of committees dedicated to improving pain management for veterans. Much of my remaining time is spent supervising a research laboratory. There we are pursuing several projects related to the questions of why pain sometimes becomes chronic after injuries and why opioids lose their effectiveness over time when used to treat chronic pain. We would like to find ways to maximize functional recovery after surgery and other forms of trauma while minimizing the risks of analgesic use. This work involves local, national and international collaborations.
