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  • Kate Kaplan, Ph.D.

    Kate Kaplan, Ph.D.

    Postdoctoral Research fellow, Behavioral Medicine

    Bio Dr. Kate Kaplan received her Bachelor's and Master's degrees in Psychology from Stanford University, where she worked with Dr. William C. Dement in the Sleep Disorders Research Center and Dr. Ian H. Gotlib in the Mood and Anxiety Disorders Laboratory. She completed her Doctoral degree at the University of California, Berkeley working with Dr. Allison Harvey in the Golden Bear Sleep and Mood Research Clinic. Dr. Kaplan completed her Predoctoral Internship at the San Francisco VA Medical Center and a Postdoctoral Clinical Fellowship in Behavioral Medicine in the Department of Psychiatry at Stanford University, where she specialized in treatment of anxiety, depression and sleep. Dr. Kaplan is presently a Postdoctoral Research Fellow with Dr. Jamie Zeitzer.

    Dr. Kaplan’s past and present research interests include (1) hypersomnia and insomnia in psychiatric disorders; (2) sleep deprivation, recovery sleep and influence of chronotype on adolescent and adult functioning; (3) the relationship between sleep and illness course in unipolar and bipolar depression. She has published multiple peer-reviewed articles, chapters, and therapist guides in the domains of sleep and affective disorders.

    In addition to her ongoing research, Dr. Kaplan has a small private practice in downtown Menlo Park. Interested clients are welcome to visit her website www.katekaplanphd.com. Dr. Kaplan's clinical interests involve working with adults who have sleep difficulties, anxiety, depression, bipolar disorder, and trauma-related illnesses. She uses Cognitive Behavioral Therapy (CBT) and mindfulness-based techniques in her clinical work. Dr. Kaplan has served as a therapist and assessor on multiple NIH-funded clinical trials, and has practiced psychotherapy in university, community outpatient and hospital settings. Dr. Kaplan also consults for various Bay Area educational and mobile health technology startups.

  • Nicholas Karayannis

    Nicholas Karayannis

    Postdoctoral Research fellow, Anesthesiology, Perioperative and Pain Medicine

    Current Research and Scholarly Interests My work centers on the development of a better understanding of how pain affects posture and movement of the body from the perspective of sensory, motor, and information processing. Understanding these interrelated aspects can enable healthcare providers to better target specific mind-body treatments at an individual level, inform the development of novel interventions that aim to restore physical function, and culminate into more effective integrative therapies and self-management programs.

  • Rishil Kathawala

    Rishil Kathawala

    Postdoctoral Research fellow, Oncology

    Current Research and Scholarly Interests Multidrug Resistance

    Our overall objective is to study the mechanism of multidrug resistance encoded by the ABCB1 gene and its product, P-glycoprotein (P-gp), a transmembrane pump that is responsible for drug efflux and resistance to many natural product chemotherapeutics. Cells enriched with P-gp have altered sensitivities to known anticancer drugs relative to cells that are ABCB1-negative, and ABCB1 is believed to be significant in the clinical response to anticancer therapies involving doxorubicin, paclitaxel and many other compounds.

    In an attempt to overcome this form of resistance, we are currently developing modulators of MDR which inhibit the natural function of P-gp and restore sensitivity to drugs in the laboratory.

    Our laboratory has identified a mutation in the ABCB1 gene which renders the cell line insensitive to MDR modulation. Studies are on-going to generate other ABCB1 gene mutations in order to determine the mechanism(s) of resistance to MDR modulation associated with alterations in P-gp structure and function. Since these MDR modulators all bind to P-gp, and most are transport substrates, such mutations will be important in defining clinically relevant structure-activity relationships of P-gp.

    We are also investigating other mechanisms in cellular models which contribute to drug resistance in the clinic such as the anti-apoptotic proto-oncogene BCL2, and the BIRC family of genes which encode for the inhibitors of apoptosis proteins (e.g. c-IAP1, c-IAP2, XIAP, and Livin).

    Taxane Mechanisms of Resistance

    The taxanes are widely used as chemotherapy agents and have substantial clinical activity in breast, ovarian, lung, and other cancers. Despite activity in human tumors, development of drug resistance presents a serious clinical problem.

    Our objective is to study mechanisms of cellular resistance to taxanes, paclitaxel (Taxol) and docetaxel (Taxotere), and the second generation taxane, cabazitaxel (Jevtana) which was approved for the treatment of hormone-refractory metastatic prostate cancer. Although the major known mechanism of resistance to these agents is multidrug resistance mediated by ABCB1, we hypothesize that the relative expression and composition of tubulin isoforms, the binding targets for these drugs, will differ in resistant cell lines which may alter drug sensitivity.

    We have established cellular models of taxane resistance in ovarian and breast cancer cell lines to further study the mechanisms of resistance to this important class of drugs, to explore approaches to overcome drug resistance, and to identify biomarkers for predicting sensitivity or resistance in the clinical setting.

  • Vandana Kaul

    Vandana Kaul

    Postdoctoral Research fellow, Transplantation Surgery

    Bio Immunologist (with a specific interest in microfluidics-based diagnostics)
    Education :
    Postdoctoral research -Stanford University , Transplantation immunology group
    Postdoctoral research-University of Houston (Chemical and Bio-molecular Engineering) and MD Anderson Cancer Center, Houston
    PhD- International Center for Genetic Engineering and Biotechnology, India
    Master's- University of Delhi, India
    Bachelor's- University of Delhi, India

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