School of Medicine
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John P. Hegarty II
Postdoctoral Research Fellow, Child Psychiatry
Bio The overarching goal of my research is to identify neurobiological subgroups and develop objective treatment prediction markers for children with neurodevelopmental disorders in order to improve biologically-based diagnosis and advance individualized treatment. Biologically-based diagnosis and treatment is extremely limited for neurodevelopment disorders but also critically-needed to increase early identification and improve treatment outcomes, especially for pervasive disorders such as autism spectrum disorder (ASD) in which early intervention is often the most efficacious. My early career training has focused on developing expertise to study the neurobiology and treatment of ASD and my research has primarily focused on the application of non-invasive neuroimaging approaches to examine brain-behavior relationships and treatment outcomes.
Thus far, my primary contributions to science fall within four primary categories: 1) identifying the neural correlates of cognitive/behavioral deficits, 2) investigating the neurobiological substrates of treatment response, 3) examining the etiological factors that contribute to alterations in brain development, and 4) contributing to ASD-related resources. My early research investigated the mechanisms associated with the cognitive deficits of alexithymia and dyslexia to further develop theories of the underlying neurobiology. My subsequent dissertation research, in which I began to focus on ASD, examined the neural correlates of treatment response to beta-blockers in adults with ASD and also assessed the contribution of cerebellar circuits to symptom presentation. I am also further developing my expertise for assessing young children with ASD in my current postdoctoral position at Stanford. My most recent research has primarily focused on examining the neural correlates of treatment response as well as the etiological factors that contribute to brain development in twins with ASD.