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  • Edward Esplin

    Edward Esplin

    Postdoctoral Medical fellow, Genetics

    Current Research and Scholarly Interests Familial adenomatous polyposis (FAP), a heritable colon cancer syndrome, causes colorectal adenocarcinoma (CRC) in children as young as 9 years, and confers 100% lifetime risk of CRC. FAP patient CRCs have accumulation of alterations in multiple tumor suppressors (i.e. Kras, p53), which accumulate due to the initial APC mutation. We hypothesize that there is a reproducible cascade of molecular changes in FAP that lead to CRC and will test this using genomic and transcriptomic technologies.

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