School of Medicine

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  • James Swartz

    James Swartz

    James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering

    Bio Using and Understanding Cell-Free Biology

    Swartz Lab General Research Focus:

    The current and projected research in the Swartz lab balances basic research in microbial metabolism, protein expression, and protein folding with a strong emphasis on compelling applications. The power and versatility of cell-free methods coupled with careful evaluation and engineering of these new systems enables a whole new range of applications and scientific investigation. Fundamental research on: the mechanisms and kinetics of ribosomal function, fundamental bioenergetics, basic mechanisms of protein folding, functional genomics, and metabolic pathway analysis is motivated by a variety of near- and medium term applications spanning medicine, energy, and environmental needs.

    Swartz Lab Application Focus:

    In the medical area , current research addresses the need for patient-specific vaccines to treat cancer. Particularly for lymphomas, there is a strong need to be able to make a new cancer vaccine for each patient. Current technologies are not practical for this demanding task, but cell-free approaches are rapid and inexpensive. We have already demonstrated feasibility in mouse tumor challenge studies and are now expanding the range of applications and working to improve the relevant technologies. Experience with these vaccines has also suggested a new and exciting format for making inexpensive and very potent vaccines for general use.

    To address pressing needs for a new and cleaner energy source, we are working towards an organism that can efficiently capture solar energy and convert it into hydrogen. The first task is to develop an oxygen tolerant hydrogenase using cell-free technology to express libraries of mutated enzymes that can be rapidly screened for improved function. Even though these are very complex enzymes, we have produced active hydrogenases with our cell-free methods. We are now perfecting the screening methods for rapid and accurate identification of improved enzymes. After these new enzymes are identified, the project will progress toward metabolic engineering and bioreactor design research to achieve the scales and economies required.

    To address environmental needs, we are developing an improved water filters using an amazing membrane protein, Aquaporin Z. It has the ability to reject all other chemicals and ions except water. We have efficiently expressed the protein into lipid bilayer vesicles and are now working to cast these membranes on porous supports to complete the development of a new and powerful water purification technology. The same lessons will be applied toward the development of a new class of biosensors that brings high sensitivity and selectivity.

  • Eric Sweet-Cordero

    Eric Sweet-Cordero

    Associate Professor (Research) of Pediatrics (Cancer Biology)

    Current Research and Scholarly Interests Our laboratory is devoted to the analysis of pathways involved in the initiation, progression, and maintenance of cancer. Utilizing the mouse as a model system, we strive to understand aberrant oncogenic signaling, the role of the tumor microenvironment and the mechanisms involved in chemotherapy response and resistance at the molecular, cellular, and organismal levels.

  • Susan M. Swetter, MD

    Susan M. Swetter, MD

    Professor of Dermatology at Palo Alto Veterans Affairs Health Care System and the Stanford University Medical Center

    Current Research and Scholarly Interests 1) Early detection of melanoma through enhanced screening and professional and public education to improve melanoma awareness. 2) Chemoprevention of melanoma and nonmelanoma skin cancers in high-risk groups. 4) Epidemiologic and sociodemographic aspects of melanoma. 4) National dermatologist liaison to the ECOG-ACRIN Melanoma Committee and Co-founder/Co-Director of the Melanoma Prevention Working Group, an interdisciplinary Intergroup collaboration dedicated to melanoma control and prevent

  • Karl Sylvester

    Karl Sylvester

    Associate Professor of Surgery (Pediatric Surgery) and Pediatrics at the Stanford University Medical Center

    Current Research and Scholarly Interests One of the current primary interests of the lab is to investigate the mechanisms by which hepatocellular injury and recovery is influenced and controlled by hepatocyte metabolism.

    A second focus of investigation is to identify molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. Specific diseases of interest include newborn sepsis and Necrotizing Enterocolitis (NEC).

  • Daniel Sze, MD, PhD

    Daniel Sze, MD, PhD

    Professor of Radiology (General Radiology) at the Stanford University Medical Center

    Current Research and Scholarly Interests Transarterial administration of chemotherapeutics, radioactive microspheres, and biologics for the treatment of unresectable tumors; management of portal hypertension and complications of cirrhosis (TIPS); treatment of complications of organ transplantation; Venous and pulmonary arterial thrombolysis and reconstruction; Stent and Stent-graft treatment of peripheral vascular diseases, aneurysms, aortic dissections

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